Effects of the β-adrenoceptor antagonists atenolol and propranolol on human whole saliva flow rate and composition

The amount of fluoride retained in the mouth following the application of dentifrices, mouthwashes, etc. may be important in determining their anticaries efficacy. In this study we investigated the relationship between the salivary flow rate and salivary fluoride clearance. Ten adults tested six mouthrinses, consisting of aqueous sodium fluoride solutions (0.013, 0.026 mol/l) with and without added sodium chloride (1.28 mol/l) or sucrose (0.44 mol/l), in a randomised order. Prior to each test, subjects swallowed, rinsed for 2 min with 2 ml water and then expectorated into a preweighed container to obtain a measure of initial saliva flow rate. Next, the procedure was repeated using one of the test rinses. Finally, samples of unstimulated whole saliva were collected for up to 3 h after each mouthrinse application and analysed for fluoride. Salivary fluoride concentrations were significantly lower after application of mouthrinses that contained either sucrose or NaCl, both of which compounds markedly enhanced salivary flow, than after the use of corresponding mouthrinses without any additive. Area under the salivary fluoride clearance curve (AUC) values were inversely correlated with salivary flow rate on an individual basis (p < 0.01). The observed behaviour could not be completely attributed to treatment dilution by saliva at the time of application.

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Effect of pilocarpine hydrochloride on unstimulated whole saliva flow rate and composition in patients with chronic graft-versus-host disease (cGVHD)

Bone Marrow Transplantation ◽

10.1038/sj.bmt.1705621 ◽

2007 ◽

Vol 39 (7) ◽

pp. 431-434 ◽

Cited By ~ 16

Author(s):

F Agha-Hosseini ◽

I Mirzaii-Dizgah ◽

L Ghavamzadeh ◽

A Ghavamzadeh ◽

Z Tohidast-Acrad

Keyword(s):

Flow Rate ◽

Graft Versus Host Disease ◽

Host Disease ◽

Graft Versus Host ◽

Saliva Flow Rate ◽

Whole Saliva ◽

Saliva Flow ◽

Unstimulated Whole Saliva

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Assessment of whole saliva flow rate in denture wearing patients

Journal of Oral Rehabilitation ◽

10.1046/j.1365-2842.2001.00624.x ◽

2001 ◽

Vol 28 (1) ◽

pp. 109-112 ◽

Cited By ~ 12

Author(s):

B. Yurdukoru ◽

H. Terzioglu ◽

T. Yilmaz

Keyword(s):

Flow Rate ◽

Saliva Flow Rate ◽

Whole Saliva ◽

Saliva Flow

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Influence of a Fed or Fasted State on the s-IgA Response to Prolonged Cycling in Active Men and Women

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.19.3.209 ◽

2009 ◽

Vol 19 (3) ◽

pp. 209-221 ◽

Cited By ~ 13

Author(s):

Judith E. Allgrove ◽

Louise Geneen ◽

Sarah Latif ◽

Michael Gleeson

Keyword(s):

Flow Rate ◽

Immunoglobulin A ◽

Secretion Rate ◽

Saliva Flow Rate ◽

Fasted State ◽

Whole Saliva ◽

Iga Response ◽

Saliva Flow ◽

Unstimulated Whole Saliva ◽

Active Adults

This study investigated the effect of a fed or fasted state on the salivary immunoglobulin A (s-IgA) response to prolonged cycling. Using a randomized, crossover design, 16 active adults (8 men and 8 women) performed 2 hr of cycling on a stationary ergometer at 65% of maximal oxygen uptake on 1 occasion after an overnight fast (FAST) and on another occasion 2 hr after consuming a 2.2-MJ high-carbohydrate meal (FED). Timed, unstimulated whole saliva samples were collected immediately before ingestion of the meal, immediately preexercise, 5 min before cessation of exercise, immediately postexercise, and 1 hr postexercise. The samples were analyzed for s-IgA concentration, osmolality, and cortisol, and saliva flow rates were determined to calculate s-IgA secretion rate. Saliva flow rate decreased by 50% during exercise (p < .05), and s-IgA concentration increased by 42% (p < .05), but s-IgA secretion rate remained unchanged. There was a 37% reduction in s-IgA:osmolality postexercise (p < .05), and salivary cortisol increased by 68% (p < .05). There was no effect of FED vs. FAST on these salivary responses. The s-IgA concentration, secretion rate, and osmolality were found to be significantly lower in women than in men throughout the exercise protocol (p < .05); however, there was no difference between genders in saliva flow rate, s-IgA:osmolality ratio, or cortisol. These data demonstrate that a fed or fasted state 2 hr before exercise does not influence resting s-IgA or the response to prolonged cycling. Furthermore, these results show lower levels of s-IgA and osmolality in women than in men at rest.

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Smoking Related Major- and Minor Salivary Gland Flow Rates, Xerostomia and Other Sicca Symptoms in Hungary

Revista de Chimie ◽

10.37358/rc.20.4.8077 ◽

2020 ◽

Vol 71 (4) ◽

pp. 373-383

Author(s):

Tamas Demeter ◽

Melinda Penzes ◽

Alexandra Kovacs ◽

Katalin Karolyhazy ◽

Csilla Erdei ◽

...

Keyword(s):

Flow Rate ◽

Smoking Status ◽

Minor Salivary Gland ◽

Age Groups ◽

Heavy Smoker ◽

Flow Rates ◽

Saliva Flow Rate ◽

Whole Saliva ◽

Sicca Symptoms ◽

Saliva Flow

Objectives of this study were to explore the prevalence of subjective and objective dryness symptoms by smoking status in different age groups, to measure whole and minor saliva flow rates, and to evaluate the possible associations between salivary parameters, oral symptoms and the intensity of smoking in a sample of Hungarian adults. Repeated cross-sectional studies were conducted in 2003 (n=600) and 2014�2018 (n=301) among Hungarian adults visiting regional outpatient dental clinics of their residence where dentist interviewed them about their subjective sicca symptoms and cigarette smoking habits (non-smoker � NS, light smoker � LIS, moderate or heavy smoker � MHS), and measured unstimulated whole saliva flow rate (UWS), palatal- and labial minor saliva flow rates to assess xerostomia objectively. The severity of xerostomia was significantly higher in among 30�39-year-old male smokers (44.8%; p=0.001), and among 18-29-year-old female smokers (52.9%; p=0.013), compared to their non-smoker counterparts (6.7% and 27.1%, respectively). UWS flow rate was significantly lower among 18-29-year-old MHS females compared to NS and LIS females in the same age group (p=0.019, p=0.015, respectively). Significantly increased palatal saliva flow rate was registered among 30�39-year-old MHS males compared to their NS counterparts (p=0.046). Our study highlighted that high intensity of smoking may cause xerostomia, a decrease in the UWS flow rate, and an increase in palatal saliva flow rate in some age groups, however, other sicca symptoms were mostly unrelated to the presence of dry mouth.

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