Possible involvement of nuclear DNA-like RNA in the control of ribosomal RNA synthesis

1973 ◽  
Vol 312 (3) ◽  
pp. 549-554 ◽  
Author(s):  
Wolfgang Schmid ◽  
Constantin E. Sekeris
Keyword(s):  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Nuclear Dna

Inhibition of rRNA synthesis following incorporation of 5-bromodeoxyuridine into DNA of Tetrahymena pyriformis

1975 ◽  
Vol 17 (3) ◽  
pp. 495-502
Author(s):  
A.E. Lykkesfeldt ◽  
H.A. Andersen
Keyword(s):  
Dna Replication ◽  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Nuclear Dna ◽  
Tetrahymena Pyriformis ◽  
Growth Conditions ◽  
Defined Medium ◽  
Rrna Synthesis ◽  
Chemically Defined Medium ◽  
Dividing Cells

Tetrahymena pyriformis was grown on chemically defined medium in the presence of 5-bromodeoxyuridine (BUdR). Under these growth conditions more than 60% of the thymidine sites in DNA were substituted with BUdR. It was found that RNA synthesis was strongly inhibited by the presence of BUdR in DNA. To assure that incorporation of BUdR into DNA was a prerequisite of the effect observed, BUdR was added to synchronously dividing cells. BUdR had no effect on the cells when present outside the period of nuclear DNA replication, whereas RNA synthesis was strongly inhibited as soon as the genes coding for ribosomal RNA had replicated in the presence of BUdR.

scholarly journals Accelerated rates of ribosomal RNA synthesis during growth of contracting heart cells in culture

1989 ◽  
Vol 264 (30) ◽  
pp. 18220-18227
Author(s):  
P J McDermott ◽  
L I Rothblum ◽  
S D Smith ◽  
H E Morgan
Keyword(s):  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Heart Cells ◽  
Cells In Culture ◽  
Contracting Heart

scholarly journals DIFFERENTIATION OF DROSOPHILA CELLS LACKING RIBOSOMAL DNA, IN VITRO

Genetics ◽  
1973 ◽  
Vol 73 (3) ◽  
pp. 429-434
Author(s):  
J James Donady ◽  
R L Seecof ◽  
M A Fox
Keyword(s):  
Drosophila Melanogaster ◽  
Ribosomal Rna ◽  
Ribosomal Dna ◽  
Rna Synthesis ◽  
Wild Type ◽  
Drosophila Cells

ABSTRACT Drosophila melanogaster embryos that lacked ribosomal DNA were obtained from appropriate crosses. Cells were taken from such embryos before overt differentiation took place and were cultured in vitro. These cells differentiated into neurons and myocytes with the same success as did wild-type controls. Therefore, ribosomal RNA synthesis is not necessary for the differentiation of neurons and myocytes in vitro.

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