The regulation of ribosomal RNA synthesis and bacterial cell growth

1994 ◽  
Vol 161 (2) ◽  
pp. 100-109 ◽  
Author(s):  
Rolf Wagner
Keyword(s):  
Cell Growth ◽  
Ribosomal Rna ◽  
Bacterial Cell ◽  
Rna Synthesis

TheDrosophila melanogastergenebrain tumornegatively regulates cell growth and ribosomal RNA synthesis

Development ◽  
2002 ◽  
Vol 129 (2) ◽  
pp. 399-407 ◽  
Author(s):  
Deborah J. Frank ◽  
Bruce A. Edgar ◽  
Mark B. Roth
Keyword(s):  
Brain Tumor ◽  
Cell Growth ◽  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Wild Type ◽  
Ribosome Synthesis ◽  
C Elegans ◽  
Functional Homolog ◽  
Mutant Cells ◽  
Large Nucleolus

The regulation of ribosome synthesis is likely to play an important role in the regulation of cell growth. Previously, we have shown that the ncl-1 gene in Caenorhabditis elegans functions as an inhibitor of cell growth and ribosome synthesis. We now indicate that the Drosophila melanogaster tumor suppressor brain tumor (brat) is an inhibitor of cell growth and is a functional homolog of the C. elegans gene ncl-1. The brat gene is able to rescue the large nucleolus phenotype of ncl-1 mutants. We also show that brat mutant cells are larger, have larger nucleoli, and have more ribosomal RNA than wild-type cells. Furthermore, brat overexpressing cells contain less ribosomal RNA than control cells. These results suggest that the tumorous phenotype of brat mutants may be due to excess cell growth and ribosome synthesis.

scholarly journals Accelerated rates of ribosomal RNA synthesis during growth of contracting heart cells in culture

1989 ◽  
Vol 264 (30) ◽  
pp. 18220-18227
Author(s):  
P J McDermott ◽  
L I Rothblum ◽  
S D Smith ◽  
H E Morgan
Keyword(s):  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Heart Cells ◽  
Cells In Culture ◽  
Contracting Heart

scholarly journals DIFFERENTIATION OF DROSOPHILA CELLS LACKING RIBOSOMAL DNA, IN VITRO

Genetics ◽  
1973 ◽  
Vol 73 (3) ◽  
pp. 429-434
Author(s):  
J James Donady ◽  
R L Seecof ◽  
M A Fox
Keyword(s):  
Drosophila Melanogaster ◽  
Ribosomal Rna ◽  
Ribosomal Dna ◽  
Rna Synthesis ◽  
Wild Type ◽  
Drosophila Cells

ABSTRACT Drosophila melanogaster embryos that lacked ribosomal DNA were obtained from appropriate crosses. Cells were taken from such embryos before overt differentiation took place and were cultured in vitro. These cells differentiated into neurons and myocytes with the same success as did wild-type controls. Therefore, ribosomal RNA synthesis is not necessary for the differentiation of neurons and myocytes in vitro.

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