Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: Blockade by protein kinase inhibitors and relationship to tat-directed trans-activation

1990 ◽  
Vol 166 (1) ◽  
pp. 349-357 ◽  
Author(s):  
Jeffrey Laurence ◽  
Santosh K. Sikder ◽  
Sanjiv Jhaveri ◽  
Jane E. Salmon
Keyword(s):  
Protein Kinase ◽  
Phorbol Ester ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Hiv 1

scholarly journals Protein kinase C regulation of organic anion transport in renal proximal tubule

1998 ◽  
Vol 274 (1) ◽  
pp. F156-F164 ◽  
Author(s):  
David S. Miller
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Kinase Inhibitors ◽  
Organic Anion ◽  
Anion Transport ◽  
Protein Kinase Inhibitors ◽  
Organic Anion Transport ◽  
Kinase C ◽  
Tissue Fluorescence

Fluorescence microscopy and digital image analysis were used to examine the role of protein kinase C (PKC) in the control of organic anion (fluorescein, FL) transport in killifish renal proximal tubules. Phorbol ester (1–100 nM) reduced cellular and luminal accumulation of FL, and protein kinase inhibitors [staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, 10–1,000 nM] increased cellular and luminal accumulation. Phorbol ester effects were blocked by staurosporine. The increases in tissue fluorescence caused by staurosporine were blocked by p-aminohippurate, indicating that they represent increased FL transport on the organic anion system. Neither phorbol ester nor staurosporine had any effects on the cell-to-lumen transport of a fluorescent organic anion that was generated intracellularly from a nonfluorescent, uncharged precursor. Finally, studies with a fluorescent PKC inhibitor showed that phorbol ester caused PKC translocation from cytoplasm to the plasma membrane. Together, these findings indicate that renal organic anion transport is negatively correlated with PKC activity and that PKC directly or indirectly controls the basolateral step in transport.

scholarly journals Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.

1990 ◽  
Vol 265 (36) ◽  
pp. 22255-22261
Author(s):  
J F Geissler ◽  
P Traxler ◽  
U Regenass ◽  
B J Murray ◽  
J L Roesel ◽  
...  
Keyword(s):  
Biological Activity ◽  
Protein Kinase ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Tyrosine Protein Kinase
Sign in / Sign up

Export Citation Format

Share Document