Hepatic peroxisome proliferation in vitamin A-deficient mice without a simultaneous increase in peroxisomal Acyl-CoA oxidase activity

1996 ◽  
Vol 51 (6) ◽  
pp. 821-827 ◽  
Author(s):  
Anna-Karin Sohlenius ◽  
Maria Reinfeldt ◽  
Katrin Bäckström ◽  
Anders Bergstrand ◽  
Joseph W. DePierre
Keyword(s):  
Vitamin A ◽  
Oxidase Activity ◽  
Simultaneous Increase ◽  
Peroxisome Proliferation ◽  
Acyl Coa Oxidase ◽  
Deficient Mice

Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice

1995 ◽  
Vol 98 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Anna-Karin Sohlenius ◽  
Karin Andersson ◽  
Jarl Olsson ◽  
Joseph W. DePierre
Keyword(s):  
Vitamin A ◽  
Perfluorooctanoic Acid ◽  
Peroxisome Proliferation ◽  
Deficient Mice

Peroxisome proliferation: Organelles or activity as an endpoint?

1993 ◽  
Vol 51 ◽  
pp. 396-397
Author(s):  
Catherine A. Taylor ◽  
Bruce M. Jarnot
Keyword(s):  
Acid Oxidation ◽  
Peroxisome Proliferation ◽  
Post Dose ◽  
Oxidation Activity ◽  
Wasting Syndrome ◽  
Perfluorodecanoic Acid ◽  
Hypolipidemic Agent ◽  
Commercially Important ◽  
Acyl Coa Oxidase ◽  
Mitochondrial Disruption

Peroxisome induction can be expressed as an increase in peroxisome area (proliferation) or as an increase in peroxisomal fatty acid oxidation (activity). This study compares proliferation and activity as endpoints for hepatic peroxisome induction by perfluorodecanoic acid (PFDA). Fluorocarboxylic acids such as PFDA represent a class of compounds possessing commercially important surfactant properties. A single 50 mg/Kg ip. dose of PFDA produces a characteristic “wasting syndrome” in male F-344 rats. Symptoms include hypophagia, weight loss, hepatomegaly, and delayed lethality. Hepatic studies reveal changes similar to those seen with the hypolipidemic agent clofibrate. These include mitochondrial disruption, endoplasmic reticulum and peroxisome proliferation, and increased peroxisomal acyl-CoA oxidase activity.Male Fisher-344 rats received a single ip. dose of 2, 20, or 50mg/Kg PFDA dissolved in 1:1 propylene glycol/water and were sacrificed 8 days post-dose. All control rats received an equal volume of vehicle ip. Animals were provided food and water ad libitum, except pair-fed controls which received the same restrictive food intake consumed by their weight-paired dosed partners (50mg/Kg PFDA group) to simulate the hypophagia associated with PFDA.

scholarly journals Premature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice

2015 ◽  
Vol 135 (4) ◽  
pp. 1108-1118 ◽  
Author(s):  
Mohsen Hosseini ◽  
Walid Mahfouf ◽  
Martin Serrano-Sanchez ◽  
Houssam Raad ◽  
Ghida Harfouche ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Oxidase Activity ◽  
Skin Aging ◽  
Nadph Oxidase Activity ◽  
Deficient Mice
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