Cholinergic receptors on cultured neurones from the central nervous system of embryonic cockroaches

Qualitative GC-MS Assessment of TCP and Tamorf Elimination in RatsNerve agents are highly toxic organophosphorus (OP) compounds. They inhibit acetylcholinesterase (AChE), an enzyme that hydrolyses acetycholine (ACh) in the nervous system. Pathophysiological changes caused by OP poisonings are primarily the consequence of surplus ACh on cholinergic receptors and in the central nervous system. Standard treatment of OP poisoning includes combined administration of carbamates, atropine, oximes and anticonvulsants. In order to improve therapy, new compounds have been synthesised and tested. Tenocyclidine (TCP) and its adamantane derivative 1-[2-(2-thienyl)-2-adamantyl] morpholine (TAMORF) have shown interesting properties against soman poisoning. In this study, we developed a qualitative GC-MS method to measure elimination of TCP and TAMORF through rat urine in order to learn more about the mechanisms through which TCP protects an organism from OP poisoning and to determine the duration of this protective effect. GC-MS showed that six hours after treatment with TCP, rat urine contained only its metabolite 1-thienylcyclohexene, while urine of rats treated with TAMORF contained both TAMORF and its metabolites.

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Decision letter for "Differential expression of five prosomatostatin genes in the central nervous system of the catshark Scyliorhinus canicula"

10.1002/cne.24898/v1/decision1 ◽

2019 ◽

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Differential Expression ◽

Scyliorhinus Canicula ◽

The Central Nervous System

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Review for "The central nervous system of whip spiders (Amblypygi): large mushroom bodies receive olfactory and visual input"

10.1002/cne.25045/v1/review1 ◽

2020 ◽

Author(s):

Harald Wolf

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Visual Input ◽

Mushroom Bodies ◽

The Central Nervous System

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Effects of Hyperoxia on Lung Utrastructure

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100067121 ◽

1970 ◽

Vol 28 ◽

pp. 26-27

Author(s):

Gladys Harrison

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Light Microscopy ◽

Oxygen Effects ◽

Age Dependent ◽

The Central Nervous System ◽

The Subject ◽

Space Age ◽

Alveolar Septa ◽

Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

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Emigration of neutrophils in the central nervous system

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100077517 ◽

1983 ◽

Vol 41 ◽

pp. 788-789

Author(s):

John L.Beggs ◽

John D. Waggener ◽

Wanda Miller ◽

Jane Watkins

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Osmium Tetroxide ◽

White Blood Cells ◽

Arterial Perfusion ◽

E Coli ◽

Intracisternal Injection ◽

The Central Nervous System ◽

Brain And Spinal Cord ◽

Interendothelial Junctions

Studies using mesenteric and ear chamber preparations have shown that interendothelial junctions provide the route for neutrophil emigration during inflammation. The term emigration refers to the passage of white blood cells across the endothelium from the vascular lumen. Although the precise pathway of transendo- thelial emigration in the central nervous system (CNS) has not been resolved, the presence of different physiological and morphological (tight junctions) properties of CNS endothelium may dictate alternate emigration pathways.To study neutrophil emigration in the CNS, we induced meningitis in guinea pigs by intracisternal injection of E. coli bacteria.In this model, leptomeningeal inflammation is well developed by 3 hr. After 3 1/2 hr, animals were sacrificed by arterial perfusion with 3% phosphate buffered glutaraldehyde. Tissues from brain and spinal cord were post-fixed in 1% osmium tetroxide, dehydrated in alcohols and propylene oxide, and embedded in Epon. Thin serial sections were cut with diamond knives and examined in a Philips 300 electron microscope.

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Mammalian Bone Marrow Acetylcholinesterase

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053024 ◽

1982 ◽

Vol 40 ◽

pp. 44-45

Author(s):

Ezzatollah Keyhani

Keyword(s):

Central Nervous System ◽

Bone Marrow ◽

Nervous System ◽

Common Property ◽

Extracellular Medium ◽

The Central Nervous System ◽

The Common ◽

Mammalian Bone

Acetylcholinesterase (EC 3.1.1.7) (ACHE) has been localized at cholinergic junctions both in the central nervous system and at the periphery and it functions in neurotransmission. ACHE was also found in other tissues without involvement in neurotransmission, but exhibiting the common property of transporting water and ions. This communication describes intracellular ACHE in mammalian bone marrow and its secretion into the extracellular medium.

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