Age related sprouting of dorsal root axons after sensory denervation

1983 ◽  
Vol 288 (1-2) ◽  
pp. 77-83 ◽  
Author(s):  
Claire E. Hulsebosch ◽  
Richard E. Coggeshall
Keyword(s):  
Dorsal Root ◽  
Age Related ◽  
Sensory Denervation

scholarly journals Age‐related molecular changes in the lumbar dorsal root ganglia of mice: Signs of sensitization, and inflammatory response

JOR Spine ◽  
2020 ◽  
Vol 3 (4) ◽  
Author(s):  
Kathleen Vincent ◽  
Chethana Prabodhanie Gallage Dona ◽  
Todd J Albert ◽  
Chitra Lekha Dahia
Keyword(s):  
Inflammatory Response ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Molecular Changes ◽  
Age Related

scholarly journals Age-Related Atrophy of Motor Axons in Mice Deficient in the Mid-Sized Neurofilament Subunit

1999 ◽  
Vol 146 (1) ◽  
pp. 181-192 ◽  
Author(s):  
Gregory A. Elder ◽  
Victor L. Friedrich ◽  
Alla Margita ◽  
Robert A. Lazzarini
Keyword(s):  
Dorsal Root ◽  
Hind Limb ◽  
Structural Integrity ◽  
Ventral Root ◽  
Null Mutation ◽  
Null Mutant ◽  
Functional Roles ◽  
Age Related ◽  
Age Dependent ◽  
Hind Limb Paralysis

Neurofilaments are central determinants of the diameter of myelinated axons. It is less clear whether neurofilaments serve other functional roles such as maintaining the structural integrity of axons over time. Here we show that an age-dependent axonal atrophy develops in the lumbar ventral roots of mice with a null mutation in the mid-sized neurofilament subunit (NF-M) but not in animals with a null mutation in the heavy neurofilament subunit (NF-H). Mice with null mutations in both genes develop atrophy in ventral and dorsal roots as well as a hind limb paralysis with aging. The atrophic process is not accompanied by significant axonal loss or anterior horn cell pathology. In the NF-M–null mutant atrophic ventral root, axons show an age-related depletion of neurofilaments and an increased ratio of microtubules/neurofilaments. By contrast, the preserved dorsal root axons of NF-M–null mutant animals do not show a similar depletion of neurofilaments. Thus, the lack of an NF-M subunit renders some axons selectively vulnerable to an age-dependent atrophic process. These studies argue that neurofilaments are necessary for the structural maintenance of some populations of axons during aging and that the NF-M subunit is especially critical.

scholarly journals Incidental Ultrastructural Findings in the Sural Nerve and Dorsal Root Ganglion of Aged Control Sprague Dawley Rats in a Nonclinical Carcinogenicity Study

2019 ◽  
Vol 48 (1) ◽  
pp. 132-143
Author(s):  
William A. Meier ◽  
Michael J. Linn ◽  
Wendell P. Davis ◽  
Jessica E. Sutherland ◽  
Alok K. Sharma
Keyword(s):  
Peripheral Nerve ◽  
Dorsal Root ◽  
Sural Nerve ◽  
Nerve Fibers ◽  
Sprague Dawley ◽  
Compression Injury ◽  
Drug Induced ◽  
Polyglucosan Bodies ◽  
Carcinogenicity Study ◽  
Age Related

Xenobiotic-induced peripheral nerve damage is a growing concern. Identifying relative risks that a new drug may cause peripheral nerve injury over long periods of administration is gathering importance in the evaluation of animal models. Separating out age-related changes in peripheral nerves of rats caused by compression injury from drug-induced effects has been difficult. Biopsy of the sural nerve is utilized in humans for investigations of peripheral neuropathy, because it is largely removed from the effects of nerve compression. This study used transmission electron microscopy to identify incidental findings in the sural nerves and dorsal root ganglia of aged control rats over time. The goal was to establish a baseline understanding of the range of possible changes that could be noted in controls compared to rats treated with any new investigative drug. In this evaluation, most sural nerve fibers from aged control rats had few ultrastructural abnormalities of pathologic significance. However, glycogenosomes, polyglucosan bodies, swollen mitochondria, autolysosomes, split myelin, Schwann cell processes, and endoneural macrophages with phagocytosed debris (considered an indication of ongoing degenerative changes) were occasionally noted.

Sign in / Sign up

Export Citation Format

Share Document