Morphological evidence for a direct projection of trigeminal nerve fibers to the primary gustatory center in the sea catfishPlotosus anguillaris

The mammalian dura mater encephali is richly supplied by trigeminal nerve fibers, a considerable proportion of which contains calcitonin gene-related peptide (CGRP). As plasma levels of CGRP are increased in some forms of headaches, the question is in which way CGRP is involved in nociceptive mechanisms within the peripheral and the central trigeminovascular system.

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Quadruple labelling method (trials of triple immunohistochemical staining). Convergence of substance-P, enkephalin and serotonin containing nerve fibers to neurons of thalamic tract of trigeminal nerve.

Dobutsu seiri ◽

10.3330/hikakuseiriseika1984.6.162 ◽

1989 ◽

Vol 6 (3) ◽

pp. 162-166

Author(s):

Takashi TASHIRO ◽

Ryutaro MATSUSHIMA

Keyword(s):

Substance P ◽

Trigeminal Nerve ◽

Immunohistochemical Staining ◽

Nerve Fibers ◽

Labelling Method

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Unilateral loss of trigeminal nerve fibers at the ventral pons

10.37532/ijav.2019.12(4).63-65 ◽

2019 ◽

Vol 12 (04) ◽

Author(s):

Tabinda Hasan

Keyword(s):

Trigeminal Nerve ◽

Nerve Fibers

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The Trigeminal Nerve and Augmentation of Regional Cerebral Blood Flow during Experimental Bacterial Meningitis

Journal of Cerebral Blood Flow & Metabolism ◽

10.1097/00004647-199611000-00029 ◽

1996 ◽

Vol 16 (6) ◽

pp. 1319-1324 ◽

Cited By ~ 21

Author(s):

Joerg R. Weber ◽

Klemens Angstwurm ◽

Geoffrey M. Bove ◽

Wolf Bürger ◽

Karl M. Einhäupl ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Bacterial Meningitis ◽

Trigeminal Nerve ◽

Regional Cerebral Blood Flow ◽

Nerve Fibers ◽

Regional Cerebral Blood ◽

Doppler Flowmetry ◽

Wall Components ◽

Brain Water

We investigated whether trigeminal nerve fibers contribute to enhanced regional cerebral blood flow (rCBF) in a rat model of experimental bacterial meningitis. rCBF was measured continuously for 6 h by laser Doppler flowmetry through thinned bone over the frontal cortex. Meningitis was induced with pneumococcal cell wall components and confirmed by a significant increase of (a) leukocytes within the cerebrospinal fluid, (b) brain water content, (c) intracranial pressure and (d) rCBF. The increase of rCBF was significantly attenuated ( p < 0.05) at 3, 4, 5, and 6 h in animals after a chronic (200 ± 21% versus 138 ± 13% at 6 h on the intact and denervated sides, respectively) but not after an acute section of the nasociliary branch of the trigeminal nerve. We conclude that elevations in blood flow during the early phase of bacterial meningitis are mediated in part by the trigeminal nerve, probably by local perivascular release of neuropeptides from afferent axons innervating the meninges.

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Nerve cells in the intracranial part of the trigeminal nerve of man and dog

Journal of Neurosurgery ◽

10.3171/jns.1971.34.5.0643 ◽

1971 ◽

Vol 34 (5) ◽

pp. 643-646 ◽

Cited By ~ 6

Author(s):

Kamal Mousa Mira ◽

Ibrahiem Abou Elnaga ◽

Hassanein El-Sherif

Keyword(s):

Trigeminal Nerve ◽

Proximal Part ◽

Nerve Fibers ◽

Nerve Cells ◽

Content Type ◽

Specific Location ◽

Nerve Bundles ◽

Motor Root ◽

Sensory Root ◽

Fine Print

✓ Nerve cells histologically similar to the ganglionic cells of the trigeminal nerve were observed in the proximal part of the sensory root and in the motor root of the human trigeminal nerve. They were also seen in the sensory root of the trigeminal nerve of the dog. Counting of the nerve fibers showed doubling of the number of nerve fibers in the three divisions compared with the fibers in the sensory root adjacent to the trigeminal ganglion. There was also an increase in the number of fibers within the sensory root as it courses centrally, while a decrease was seen in the number of fibers in the proximal part of the motor root. Intermediate nerve bundles were seen leaving the motor root near the pons and joining the sensory root centrally. The fibers of the sensory root corresponding to each peripheral division maintained their specific location in the sensory root during the whole course centrally.

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Co-increase of Nerve Fibers and HLA-DRand/or Factor-XIIIa-expressing Dendritic Cells in Dentinal Caries-affected Regions of the Human Dental Pulp: An Immunohistochemical Study

Journal of Dental Research ◽

10.1177/00220345990780100401 ◽

1999 ◽

Vol 78 (10) ◽

pp. 1596-1608 ◽

Cited By ~ 32

Author(s):

K. Sakurai ◽

T. Okiji ◽

H. Suda

Keyword(s):

Dendritic Cells ◽

Dental Pulp ◽

Coagulation Factor ◽

Nerve Fibers ◽

Factor Xiiia ◽

Morphological Evidence ◽

Immunoperoxidase Staining ◽

Dentinal Tubule ◽

Reparative Dentin ◽

Carious Teeth

Neuro-immune interaction has been suggested to play some modulatory role in the immunodefense of the dentin/pulp complex. In this study, we performed a simultaneous immunohistochemical observation of neural elements and pulpal dendritic cells (PDCs) on human carious teeth, to obtain morphological evidence for neuro-immune interaction in response to dentinal tubule-derived carious stimuli. Human third molars bearing a pulp-exposure-free caries lesion were studied. Immunoperoxidase staining was performed with anti-HLA-DR, anti-coagulation factor XIIIa, and anti-CD14 as PDC markers, and anti-low-affinity nerve growth factor receptor (NGFR), anti-protein gene products 9.5, and anti-calcitonin gene-related peptide as nerve markers. The carious teeth usually exhibited localized accumulation of both PDCs and nerve fibers immunoreactive to each marker, in the para-odontoblastic region corresponding to the pulpal end of carious dentinal tubules. Semi-quantitative digital densitometry revealed that pixel numbers corresponding to factor-XIIIa- and NGFRimmunoreactivity were significantly higher in the carious regions than those in the non-carious regions of the same teeth as well as those in the corresponding regions of intact teeth. Classification of specimens with respect to caries depth showed that the co-increase was most apparent in teeth with superficial caries. The increase of PDCs was less pronounced in carious teeth with reparative dentin. These findings suggest that both pulpal nerves and PDCs respond promptly and actively to dentinal tubule-derived carious stimuli. The synchronized accumulation of the two structures suggests an increased opportunity for neuro-immune interaction that may be of significance in the modulation of pathological processes in the dental pulp.

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Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia

Case Reports in Ophthalmological Medicine ◽

10.1155/2018/6815407 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Aya Kodama-Takahashi ◽

Koji Sugioka ◽

Tomoko Sato ◽

Koichi Nishida ◽

Keiichi Aomatsu ◽

...

Keyword(s):

Nerve Block ◽

Trigeminal Nerve ◽

Postherpetic Neuralgia ◽

Nerve Fibers ◽

Gasserian Ganglion ◽

Ganglion Block ◽

Corneal Epithelial ◽

Corneal Sensation ◽

The Right ◽

Neurotrophic Keratopathy

Purpose. To report a case of persistent corneal epithelial defect that had occurred after a trigeminal nerve block. Case Presentation. A 75-year-old female had suffered from postherpetic neuralgia for 8 years. She underwent Gasserian ganglion block surgery and noticed declining visual acuity in the right eye on the following day. She presented with severe hyperemia and corneal epithelial defects in the right eye and experienced remarkable reduction of sensitivity in the right cornea. She was diagnosed with neurotrophic keratopathy. Ofloxacin eye ointment and rebamipide ophthalmic suspension ameliorated the corneal epithelial defects but superficial punctate keratopathy, corneal superficial neovascularization, and Descemet’s fold persisted. Although the epithelial defects occasionally recurred, the corneal sensation and epithelial defects, Descemet’s fold, and corneal superficial neovascularization all improved around 5 months after trigeminal nerve block. The HRT II Rostock Cornea Module (RCM) could not detect any corneal subbasal nerve fibers at postoperative 4 months; however, it could detect them at postoperative 6 months. Conclusions. As the nerve block effect wore off, the corneal subbasal nerve fibers slowly regenerated. As the corneal sensation improved, the corneal epithelial defects and superficial neovascularization also improved. The HRT II RCM appeared useful for observing loss and regeneration of the corneal subbasal nerve fibers.

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