Reduced hippocampal CA1 Ca2+-induced long-term potentiation is associated with age-dependent impairment of spatial learning

1995 ◽  
Vol 686 (1) ◽  
pp. 107-110 ◽  
Author(s):  
Giovanni Diana ◽  
Maria Rosaria Domenici ◽  
Arsenia Scotti de Carolis ◽  
Alberto Loizzo ◽  
Stefano Sagratella
Keyword(s):  
Spatial Learning ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Age Dependent

scholarly journals Astrocytes dystrophy in ageing brain parallels impaired synaptic plasticity

2020 ◽  
Author(s):  
Alexander Popov ◽  
Alexey Brazhe ◽  
Pavel Denisov ◽  
Oksana Sutyagina ◽  
Natalia Lazareva ◽  
...  
Keyword(s):  
Volume Fraction ◽  
Long Term Potentiation ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Age Dependent ◽  
And Function ◽  
The Impact

Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these into the cognitive decline in the senescent brain. The prevalent view on age-dependent increase in reactive astrogliosis and astrocytic hypertrophy requires scrutiny and detailed analysis. Using two-photon microscopy in conjunction with 3D reconstruction, Sholl and volume fraction analysis we demonstrate a significant reduction in the number and the length of astrocytic processes, in astrocytic territorial domains and in astrocyte-to-astrocyte coupling in the aged brain. Probing physiology of astrocytes with patch-clamp and Ca2+ imaging revealed deficits in K+ and glutamate clearance, and spatiotemporal reorganization of Ca2+ events in old astrocytes. These changes paralleled impaired synaptic long-term potentiation (LTP) in hippocampal CA1 in old mice. Our findings may explain astroglial mechanisms of age-dependent decline in learning and memory.

Long-term potentiation in the hippocampal CA1 area and dentate gyrus plays different roles in spatial learning

2003 ◽  
Vol 17 (2) ◽  
pp. 341-349 ◽  
Author(s):  
Takashi Okada ◽  
Nobuaki Yamada ◽  
Keisuke Tsuzuki ◽  
Hiroshi P. M. Horikawa ◽  
Kohichi Tanaka ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Spatial Learning ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Hippocampal Ca1 Area ◽  
Ca1 Area

Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region

2010 ◽  
Vol 56 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Daisuke Ibi ◽  
Atsumi Nitta ◽  
Kumiko Ishige ◽  
Xiaobo Cen ◽  
Tomohiro Ohtakara ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Long Term Potentiation ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Term Potentiation ◽  
Hippocampal Ca1

scholarly journals An Endogenous RNA Transcript Antisense to CNGα1 Cation Channel mRNA

2002 ◽  
Vol 13 (10) ◽  
pp. 3696-3705 ◽  
Author(s):  
Chin-Hung Cheng ◽  
David Tai-Wai Yew ◽  
Hiu-Yee Kwan ◽  
Qing Zhou ◽  
Yu Huang ◽  
...  
Keyword(s):  
Expression System ◽  
Expression Patterns ◽  
Long Term Potentiation ◽  
Information Storage ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Oocyte Expression System ◽  
Neuronal Functions ◽  
Rna Transcript

CNG channels are cyclic nucleotide-gated Ca2+-permeable channels that are suggested to be involved in the activity-dependent alterations of synaptic strength that are thought to underlie information storage in the CNS. In this study, we isolated an endogenous RNA transcript antisense to CNGα1 mRNA. This transcript was capable of down-regulating the expression of sense CNGα1 in theXenopus oocyte expression system. RT-PCR, Northern blot, and in situ hybridization analyses showed that the transcript was coexpressed with CNGα1 mRNA in many regions of human brain, notably in those regions that were involved in long-term potentiation and long-term depression, such as hippocampal CA1 and CA3, dentate gyrus, and cerebellar Purkinje layer. Comparison of expression patterns between adult and fetal cerebral cortex revealed that there were concurrent developmental changes in the expression levels of anti-CNG1 and CNGα1. Treatment of human glioma cell T98 with thyroid hormone T3 caused a significant increase in anti-CNG1 expression and a parallel decrease in sense CNGα1 expression. These data suggest that the suppression of CNGα1 expression by anti-CNG1 may play an important role in neuronal functions, especially in synaptic plasticity and cortical development. Endogenous antisense RNA-mediated regulation may represent a new mechanism through which the activity of ion channels can be regulated in the human CNS.

Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade

Neuroscience ◽  
1996 ◽  
Vol 74 (2) ◽  
pp. 331-339 ◽  
Author(s):  
F.H Brucato ◽  
E.D Levin ◽  
D.D Mott ◽  
D.V Lewis ◽  
W.A Wilson ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Gabab Receptor ◽  
Long Term Potentiation ◽  
Receptor Blockade ◽  
Term Potentiation

Seizure induced synthesis of fibronectin is rapid and age dependent: implications for long-term potentiation and sprouting

1998 ◽  
Vol 812 (1-2) ◽  
pp. 209-215 ◽  
Author(s):  
Keith B Hoffman ◽  
Jason K Pinkstaff ◽  
Christine M Gall ◽  
Gary Lynch
Keyword(s):  
Long Term Potentiation ◽  
Term Potentiation ◽  
Age Dependent

Dissociation between genes activated in long-term potentiation and in spatial learning in the rat

1998 ◽  
Vol 251 (1) ◽  
pp. 41-44 ◽  
Author(s):  
G Richter-Levin ◽  
K.L Thomas ◽  
S.P Hunt ◽  
T.V.P Bliss
Keyword(s):  
Spatial Learning ◽  
Long Term Potentiation ◽  
Term Potentiation
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