A relationship between nuclear DNA and RNA synthetic activities and the changes produced by n-methyl-n-nitroso urethane: A study using Amoeba proteus as a single cell model

1974 ◽  
Vol 8 (4) ◽  
pp. 269-283 ◽  
Author(s):  
M.J. Ord
Keyword(s):  
Single Cell ◽  
Nuclear Dna ◽  
Cell Model ◽  
Amoeba Proteus ◽  
Dna And Rna ◽  
Single Cell Model

Calibration of single-cell model parameters based on membrane resistance improves the accuracy of cardiac tissue simulations

2021 ◽  
pp. 101375
Author(s):  
Elnaz Pouranbarani ◽  
Lucas Arantes Berg ◽  
Rafael Sachetto Oliveira ◽  
Rodrigo Weber dos Santos ◽  
Anders Nygren
Keyword(s):  
Single Cell ◽  
Cardiac Tissue ◽  
Cell Model ◽  
Membrane Resistance ◽  
Model Parameters ◽  
Single Cell Model

scholarly journals Direct observation of frequency modulated transcription in single cells using light activation

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Daniel R Larson ◽  
Christoph Fritzsch ◽  
Liang Sun ◽  
Xiuhau Meng ◽  
David S Lawrence ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Molecule ◽  
Single Cell Analysis ◽  
Cell Model ◽  
Single Cells ◽  
Single Gene ◽  
Gene Activation ◽  
Light Activation ◽  
Dynamic Synthesis ◽  
Single Cell Model

Single-cell analysis has revealed that transcription is dynamic and stochastic, but tools are lacking that can determine the mechanism operating at a single gene. Here we utilize single-molecule observations of RNA in fixed and living cells to develop a single-cell model of steroid-receptor mediated gene activation. We determine that steroids drive mRNA synthesis by frequency modulation of transcription. This digital behavior in single cells gives rise to the well-known analog dose response across the population. To test this model, we developed a light-activation technology to turn on a single steroid-responsive gene and follow dynamic synthesis of RNA from the activated locus.

scholarly journals Functional analysis of the methyltransferase SMYD in the single-cell model organism Tetrahymena thermophila

2020 ◽  
Vol 2 (2) ◽  
pp. 109-122
Author(s):  
Xiaolu Zhao ◽  
Yuan Li ◽  
Lili Duan ◽  
Xiao Chen ◽  
Fengbiao Mao ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Single Cell ◽  
Tetrahymena Thermophila ◽  
Cell Model ◽  
Model Organism ◽  
Single Cell Model

scholarly journals Complete Transcriptome of the Soybean Root Hair Cell, a Single-Cell Model, and Its Alteration in Response to Bradyrhizobium japonicum Infection

2009 ◽  
Vol 152 (2) ◽  
pp. 541-552 ◽  
Author(s):  
Marc Libault ◽  
Andrew Farmer ◽  
Laurent Brechenmacher ◽  
Jenny Drnevich ◽  
Raymond J. Langley ◽  
...  
Keyword(s):  
Hair Cell ◽  
Single Cell ◽  
Root Hair ◽  
Bradyrhizobium Japonicum ◽  
Cell Model ◽  
Soybean Root ◽  
Root Hair Cell ◽  
Single Cell Model
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