Cell proliferation and DNA replication in the imaginal wing disc of Drosophila melanogaster

1984 ◽  
Vol 103 (1) ◽  
pp. 28-37 ◽  
Author(s):  
Paul N. Adler ◽  
Margaret MacQueen
Keyword(s):  
Cell Proliferation ◽  
Drosophila Melanogaster ◽  
Dna Replication ◽  
Wing Disc ◽  
Imaginal Wing Disc

Connecting Hh, Dpp and EGF signalling in patterning of theDrosophilawing; the pivotal role ofcollier/knotin the AP organiser

Development ◽  
2002 ◽  
Vol 129 (18) ◽  
pp. 4261-4269 ◽  
Author(s):  
Michèle Crozatier ◽  
Bruno Glise ◽  
Alain Vincent
Keyword(s):  
Cell Proliferation ◽  
Central Region ◽  
Wing Disc ◽  
Signalling Pathways ◽  
Wild Type ◽  
Drosophila Wing ◽  
Egfr Ligand ◽  
Imaginal Wing Disc ◽  
Primary Determinant ◽  
Dose Dependent

Hedgehog (Hh) signalling from posterior (P) to anterior (A) cells is the primary determinant of AP polarity in the limb field in insects and vertebrates. Hh acts in part by inducing expression of Decapentaplegic (Dpp), but how Hh and Dpp together pattern the central region of the Drosophila wing remains largely unknown. We have re-examined the role played by Collier (Col), a dose-dependent Hh target activated in cells along the AP boundary, the AP organiser in the imaginal wing disc. We found that col mutant wings are smaller than wild type and lack L4 vein, in addition to missing the L3-L4 intervein and mis-positioning of the anterior L3 vein. We link these phenotypes to col requirement for the local upregulation of both emc and N, two genes involved in the control of cell proliferation, the EGFR ligand Vein and the intervein determination gene blistered. We further show that attenuation of Dpp signalling in the AP organiser is also col dependent and, in conjunction with Vein upregulation, required for formation of L4 vein. A model recapitulating the molecular interplay between the Hh, Dpp and EGF signalling pathways in the wing AP organiser is presented.

Transdetermination in imaginal wing disc fragments of Drosophila melanogaster

1983 ◽  
Vol 97 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Brooke S. Kirby ◽  
Peter J. Bryant ◽  
Howard A. Schneiderman
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Disc ◽  
Imaginal Wing Disc

scholarly journals Analysis of the Function of Apoptosis during Imaginal Wing Disc Regeneration in Drosophila melanogaster

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165554 ◽  
Author(s):  
Sandra Diaz-Garcia ◽  
Sara Ahmed ◽  
Antonio Baonza
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Disc ◽  
Disc Regeneration ◽  
Imaginal Wing Disc

Regeneration following duplication in imaginal wing disc fragments of Drosophila melanogaster

1982 ◽  
Vol 90 (2) ◽  
pp. 259-271 ◽  
Author(s):  
Brooke S. Kirby ◽  
Peter J. Bryant ◽  
Howard A. Schneiderman
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Disc ◽  
Imaginal Wing Disc

Pattern regulation in fragments of Drosophila wing discs which show variable wound healing

Development ◽  
1985 ◽  
Vol 85 (1) ◽  
pp. 95-109
Author(s):  
Leslie Dale ◽  
Mary Bownes
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Wing Disc ◽  
Wound Edge ◽  
Drosophila Wing ◽  
Imaginal Wing Disc ◽  
Wing Discs ◽  
Pattern Regulation ◽  
Mode Of Regulation

When complementary fragments of the imaginal wing disc of Drosophila are cultured for several days prior to inducing metamorphosis, usually one fragment will regenerate while the second duplicates. It has been proposed that wound healing plays an important part in disc regulation by initiating cell proliferation and determining the mode of regulation (regeneration/duplication). To test the latter proposal 15 types of wing disc fragments were examined for variability both in the mode of wound healing and the mode of pattern regulation. Two modes of wound healing were observed, regular—the two wound edges heal with each other, and irregular—each wound edge heals with itself. When cultured separately fragments that healed regularly regenerated, while fragments that healed irregularly duplicated. This suggests that the mode of wound healing determines the mode of pattern regulation.

scholarly journals Configurational forces for growth and shape regulations in morphogenesis

2012 ◽  
Vol 60 (2) ◽  
pp. 253-257 ◽  
Author(s):  
P. Ciarletta ◽  
D. Ambrosi ◽  
G.A. Maugin
Keyword(s):  
Drosophila Melanogaster ◽  
Mass Transport ◽  
Environmental Conditions ◽  
Continuum Model ◽  
Growth Control ◽  
Wing Disc ◽  
Configurational Forces ◽  
Biochemical Processes ◽  
Imaginal Wing Disc ◽  
Living Organisms

Abstract. Morphogenetic theories investigate the mechanisms of creation and regulation of definite biological forms in living organisms. The incredible diversity of shapes and sizes is generated through a barely unknown coordination of biochemical processes occurring at molecular levels. Such a crosstalk not only defines the rules of a robust scheme of matter differentiation, but it also has the capacity to adapt with respect to some variations of the environmental conditions. In this work, we propose a continuum model of growth and mass transport for biological materials during morphogenetic processes. Using the theory of configurational forces, we define the thermomechanical bases for understanding how both the mechanical and the biochemical states can orchestrate growth. The model is successfully applied to describe the morphogen-driven growth control in the imaginal wing disc of Drosophila melanogaster.

Sign in / Sign up

Export Citation Format

Share Document