Dopaminergic innervation and inhibition of ciliary movement in the ciliated epithelium of frog palatine mucosa

1983 ◽  
Vol 90 (4) ◽  
pp. 325-331 ◽  
Author(s):  
Ikuo Maruyama ◽  
Toshiharu Yamamoto ◽  
Junzo Ochi ◽  
Yasumitsu Nakai ◽  
Shigeo Yamada

In 1906 R. S. Lillie (7) published an account of the effects of various pure sodium salts upon the ciliated epithelium of Mytilus edulis . He found that the ions could be arranged in the following order of “toxicity,” Cl' <NO 3 ' < Br' < I' <SCN'. Lillie also referred to the effect which various anions have upon the amount of water taken up by the cells from their external medium, and arranged the ions in the following order of efficiency in causing an absorption of water by the cells. CH 3 COO' < Cl' < NO 3 ' < C10 3 ' < Br' < I' < SCN' < BrO 3 ' < OH'.


2005 ◽  
Vol 114 (4) ◽  
pp. 279-288 ◽  
Author(s):  
Satish Govindaraj ◽  
Elena Fedorova ◽  
Eric M. Genden ◽  
Houtan Chaboki ◽  
Jonathan S. Bromberg ◽  
...  

Prior work has demonstrated that immunosuppressed orthotopic tracheal allografts undergo progressive reepithelialization over a 48-day period with recipient-derived tracheal epithelium. We hypothesized that reepithelialization of tracheal allografts would prevent rejection after withdrawal of immunosuppression. BALB/c murine tracheal grafts were transplanted orthotopically into either syngeneic or allogeneic C57/BL6 recipients. The recipients were either not immunosuppressed, immunosuppressed with cyclosporine A (10 mg/kg per day) continuously, or immunosuppressed for 48 days and then withdrawn from immunosuppression. The grafts were assessed for acute and chronic rejection 10 days and 50 days after immunosuppression withdrawal. The immunosuppressed allograft recipients maintained a ciliated epithelium acutely and chronically after immunosuppression withdrawal. Ten days after immunosuppression withdrawal, there was a mild cellular infiltrate, which resolved 50 days after withdrawal. Electron microscopy, lymphocyte subpopulation assays, and lamina propria analysis demonstrated that immunosuppression withdrawal did not result in tracheal allograft rejection. In vitro and in vivo assessments did not demonstrate evidence of systemic or local immune tolerance. We conclude that reepithelialization of orthotopic tracheal allografts with recipient-derived mucosa prevents rejection of allograft segments. Tracheal transplantation may require only transient immunosuppression, which can be withdrawn after tracheal reepithelialization.


2014 ◽  
Vol 39 (3) ◽  
pp. 499-505 ◽  
Author(s):  
Teruya Ohba ◽  
Jiegou Xu ◽  
David B. Alexander ◽  
Akane Yamada ◽  
Jun Kanno ◽  
...  

1982 ◽  
Vol 63 (4) ◽  
pp. 26-29
Author(s):  
V. A. Anokhin

The activation of the kinin system of the blood in diseases of the respiratory system leads to an increase in the inflammatory response in the respiratory tract, causes bronchospasm to a large extent, and has an inhibitory effect on the function of the ciliated epithelium. There are no unequivocal judgments about the therapeutic effect of prednisolone in obstructive bronchitis and bronchiolitis in the literature. There is a negative answer to this question. At the same time, the beneficial effect of corticosteroids on pulmonary mechanics in bronchiolitis was noted.


1890 ◽  
Vol 16 ◽  
pp. 119-120 ◽  
Author(s):  
John Berry Haycraft ◽  
E. W. Carlier

(Abstract.)In man, in the rabbit, and some other animals the trachea is built up of a series of cartilaginous rings incomplete behind; the rings being completed in this position by the trachealis muscle.The mucous membrane forms a smooth cylindrical lining for the whole tube, and is covered by a ciliated epithelium.In the cat and dog the cartilage rings completely encircle the trachea, and overlap posteriorly, and the trachealis muscle, which is well developed, is placed outside the cartilage, and has a powerful action in varying the diameter of the tube.When this muscle contracts the overlapping ends of the cartilage ride one upon another, and the projecting ends form a vertical ridge down the inside of the trachea, which can be readily seen on slitting the organ open. This ridge is separated by a deep groove from the other end of the plate.


2017 ◽  
Vol 181 (9) ◽  
pp. 236-236 ◽  
Author(s):  
Aris Malo ◽  
Sjaak de Wit ◽  
Wim A J M Swart ◽  
Jane K A Cook

The work reported here is an initial attempt to find an alternative method by which the safety of live-attenuated Newcastle disease virus (NDV) vaccines for the respiratory tract of young chickens can be assessed. The current recommended methods involve either the subjective assessment of respiratory signs, or raise ethical concerns, as in the case of the intracerebral pathogenicity index. The two methods considered here were the use of tracheal organ cultures to assess the level of ciliostasis which the vaccines caused to the ciliated epithelium of the trachea and the incorporation of a pathogenic strain ofEscherichia coliin the inoculum in order to induce colibacillosis. Both methods were successful in confirming the safety of the two vaccines. However, these results are only preliminary and more studies need to be performed to determine whether one or both methods have potential, either to replace the existing statutory tests, or provide a test which might be useful during the development stages of a new live-attenuated NDV vaccine.


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