scholarly journals MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents

2014 ◽  
Vol 39 (3) ◽  
pp. 499-505 ◽  
Author(s):  
Teruya Ohba ◽  
Jiegou Xu ◽  
David B. Alexander ◽  
Akane Yamada ◽  
Jun Kanno ◽  
...  
Author(s):  
Gladys Harrison

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.


2020 ◽  
Vol 47 (2) ◽  
pp. 392-401
Author(s):  
T. R. Birkhead ◽  
G. Axon ◽  
J. R. Middleton

Most of the approximately 75 known eggs of the extinct great auk ( Pinguinus impennis) are in public museums, with a few in private collections. A small number of these eggs has sustained damage, either at the time of collection or subsequently, and two of these eggs are known to have been repaired. The two eggs suffered rather different types of damage and were subsequently restored using different techniques. The first, known as Bourman Labrey's egg, sustained extensive damage sometime prior to the 1840s, when the shell was broken into numerous pieces. This egg was repaired by William Yarrell in the 1840s, and when it was restored again in 2018, it was discovered that Yarrell's restoration had involved the use of an elaborate cardboard armature. This egg is currently in a private collection. The second egg, known as the Scarborough egg, bequeathed to the Scarborough Museum in 1877, was damaged (by unknown causes) and repaired, probably by the then curator at Scarborough, W. J. Clarke, in 1906. This egg was damaged when one or more pieces were broken adjacent to the blowhole at the narrow end (where there was some pre-existing damage). The media reports at the time exaggerated the extent of the damage, suggesting that the egg was broken almost in two. Possible reasons for this exaggeration are discussed. Recent examination using a black light and ultraviolet (UV) revealed that the eggshell had once borne the words, “a Penguin's Egg”, that were subsequently removed by scraping.


2005 ◽  
Vol 114 (4) ◽  
pp. 279-288 ◽  
Author(s):  
Satish Govindaraj ◽  
Elena Fedorova ◽  
Eric M. Genden ◽  
Houtan Chaboki ◽  
Jonathan S. Bromberg ◽  
...  

Prior work has demonstrated that immunosuppressed orthotopic tracheal allografts undergo progressive reepithelialization over a 48-day period with recipient-derived tracheal epithelium. We hypothesized that reepithelialization of tracheal allografts would prevent rejection after withdrawal of immunosuppression. BALB/c murine tracheal grafts were transplanted orthotopically into either syngeneic or allogeneic C57/BL6 recipients. The recipients were either not immunosuppressed, immunosuppressed with cyclosporine A (10 mg/kg per day) continuously, or immunosuppressed for 48 days and then withdrawn from immunosuppression. The grafts were assessed for acute and chronic rejection 10 days and 50 days after immunosuppression withdrawal. The immunosuppressed allograft recipients maintained a ciliated epithelium acutely and chronically after immunosuppression withdrawal. Ten days after immunosuppression withdrawal, there was a mild cellular infiltrate, which resolved 50 days after withdrawal. Electron microscopy, lymphocyte subpopulation assays, and lamina propria analysis demonstrated that immunosuppression withdrawal did not result in tracheal allograft rejection. In vitro and in vivo assessments did not demonstrate evidence of systemic or local immune tolerance. We conclude that reepithelialization of orthotopic tracheal allografts with recipient-derived mucosa prevents rejection of allograft segments. Tracheal transplantation may require only transient immunosuppression, which can be withdrawn after tracheal reepithelialization.


1996 ◽  
Vol 21 (4) ◽  
pp. 534-537 ◽  
Author(s):  
S. STAHL ◽  
Y. HAR-SHAI ◽  
B. HIRSHOWITZ

A skin stretching device (SSD) harnessing the viscoelastic properties of skin using incremental traction has been used in 20 patients with skin deficits in the upper extremity. Complications were few considering the extensive damage to the skin and included slight partial dehiscence, necrosis of skin edges, local infection and hypertrophic scars. All wounds healed without the need for further surgical procedures. Application of the SSD is simple and it can even be used at the bedside under local anaesthesia. It reduces the need for more complicated surgical procedures like grafts or flaps.


1976 ◽  
Vol 66 (3) ◽  
pp. 887-901 ◽  
Author(s):  
S. Singh ◽  
A. K. Jain ◽  
P. Sinha ◽  
V. N. Singh ◽  
L. S. Srivastava

abstract On January 19, 1975 an earthquake of magnitude 6.8 occurred in the border districts of Himachal Pradesh, India. The earthquake caused considerable loss of life and varying degrees of damage to construction in the area. Traditional and recent buildings suffered extensive damage. Landslides, rock falls and avalanches caused considerable damage to the Hindustan-Tibet road. Extensive fissures in the ground developed at the epicenter. Greatest damage was noted along the N-S trending Kaurik-Chango fault following the Parachu and Spiti river valleys, suggesting its genetic interrelationship with the earthquake.


1982 ◽  
Vol 63 (4) ◽  
pp. 26-29
Author(s):  
V. A. Anokhin

The activation of the kinin system of the blood in diseases of the respiratory system leads to an increase in the inflammatory response in the respiratory tract, causes bronchospasm to a large extent, and has an inhibitory effect on the function of the ciliated epithelium. There are no unequivocal judgments about the therapeutic effect of prednisolone in obstructive bronchitis and bronchiolitis in the literature. There is a negative answer to this question. At the same time, the beneficial effect of corticosteroids on pulmonary mechanics in bronchiolitis was noted.


2007 ◽  
Vol 7 (1) ◽  
pp. 129-139 ◽  
Author(s):  
J. Bech ◽  
R. Pascual ◽  
T. Rigo ◽  
N. Pineda ◽  
J. M. López ◽  
...  

Abstract. This paper presents an observational study of the tornado outbreak that took place on the 7 September 2005 in the Llobregat delta river, affecting a densely populated and urbanised area and the Barcelona International airport (NE Spain). The site survey confirmed at least five short-lived tornadoes. Four of them were weak (F0, F1) and the other one was significant (F2 on the Fujita scale). They started mostly as waterspouts and moved later inland causing extensive damage estimated in 9 million Euros, three injured people but fortunately no fatalities. Large scale forcing was provided by upper level diffluence and low level warm air advection. Satellite and weather radar images revealed the development of the cells that spawned the waterspouts along a mesoscale convergence line in a highly sheared and relatively low buoyant environment. Further analysis indicated characteristics that could be attributed indistinctively to non-supercell or to mini-supercell thunderstorms.


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