Kallikrein blood system in acute respiratory diseases with bronchial obstruction syndrome in children

1982 ◽  
Vol 63 (4) ◽  
pp. 26-29
Author(s):  
V. A. Anokhin
Keyword(s):  
Respiratory Tract ◽  
Respiratory Diseases ◽  
Inhibitory Effect ◽  
Negative Answer ◽  
Blood System ◽  
Pulmonary Mechanics ◽  
Bronchial Obstruction ◽  
Ciliated Epithelium ◽  
Kinin System ◽  
Acute Respiratory Diseases

The activation of the kinin system of the blood in diseases of the respiratory system leads to an increase in the inflammatory response in the respiratory tract, causes bronchospasm to a large extent, and has an inhibitory effect on the function of the ciliated epithelium. There are no unequivocal judgments about the therapeutic effect of prednisolone in obstructive bronchitis and bronchiolitis in the literature. There is a negative answer to this question. At the same time, the beneficial effect of corticosteroids on pulmonary mechanics in bronchiolitis was noted.

scholarly journals Treatment of respiratory diseases with inhalation patches

2019 ◽  
pp. 89-94
Author(s):  
L S. Starostina
Keyword(s):  
Adverse Events ◽  
Respiratory Tract ◽  
Risk Reduction ◽  
Mucous Membrane ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Early Age ◽  
Ciliated Epithelium ◽  
Constant Attention ◽  
High Incidence

The high incidence of respiratory infections at an early age requires constant attention of doctors of various specialties. It should be born in mind that the development of the respiratory tract in young children has unique features, and that different drugs can have different effects on the mucous membrane and ciliated epithelium. Also take into account the possibility of using different ways drugs can be administered to prevent and treat respiratory infections with due account for the age of the child, the effectiveness of action and adverse events risk reduction.

scholarly journals THE MANIFESTATON FEATURES OF ACUTE RESPIRATORY DISEASES IN INFANTS

2019 ◽  
Vol 19 (4) ◽  
pp. 38-42 ◽  
Author(s):  
S.M. Tsvirenko ◽  
N.S. Artiomova ◽  
O.I. Ananevych ◽  
I.I. Adruschenko ◽  
O.V. Bеlan
Keyword(s):  
Medical Records ◽  
Inpatient Treatment ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
General Structure ◽  
Underlying Disease ◽  
Community Acquired Pneumonia ◽  
Bronchial Obstruction ◽  
Respiratory Pathology ◽  
Acute Respiratory Diseases

According to WHO, acute respiratory diseases are at the forefront of the incidence rate of infants and are among the most common diseases due to which children are hospitalized. The aim of the research was to analyze the structure of morbidity and features of the course in acute respiratory diseases in infants with the study of the frequency of leading nosological forms that required inpatient treatment. A retrospective analysis of the medical records of inpatients (3845 children), treated during 2016-2018 was conducted. The study found that there is a tendency for an increase in the number of infants who require inpatient treatment, as well as an increased number of nosologies in the treated children. As the underlying disease, the first place in the structure of the morbidity belonged to acute respiratory viral infections. In the dynamics of the studied years, an increase in the frequency of acute obstructive bronchitis was noted. This pathology has the second place in the structure of morbidity among hospitalized children. The permanent third place in the structure of nosologies belongs to acute pneumonia. The premorbid background of most children with bronchial obstruction syndrome and acute community-acquired pneumonia was aggravated. The most commonly determined disorders were I-II degree anemia, overweight, impaired calcium metabolism, aggravated allergic history, transient immune deficiency. Conclusions. Our analysis of the structure of acute respiratory pathology in infants who required inpatient treatment showed that in the dynamics of 2016-2018, there was an increase in cases of acute obstructive bronchitis and acute community-acquired pneumonia. The study of general structure of nosologies in children treated at the inpatient department revealed an increase in their number and a tendency for the formation of comorbid pathology in infants.

scholarly journals Efficiency of the irs-19 aerosol vaccine in children with relapsing diseases of upper respiratory tract

2021 ◽  
Vol 82 (1) ◽  
pp. 15-16
Author(s):  
G. A. Makovetskaya ◽  
V. V. Zhestkova ◽  
T. L. Kuznetsova
Keyword(s):  
Infectious Diseases ◽  
Respiratory Tract ◽  
Respiratory Diseases ◽  
Upper Respiratory Tract ◽  
Acute Respiratory Diseases ◽  
Upper Respiratory

The use of the IRS-19 aerosol vaccine results in decreasing of the rate of the infectious diseases of otorhinolaryngologic organs in children suffering from adenoids, sinusitis, complications of acute respiratory diseases.

Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

Predicting the risk of cardiovascular disorders in children with tonsillitis syndrome in acute respiratory diseases

2020 ◽  
Vol 18 (1) ◽  
pp. 82-87
Author(s):  
S. V. PLAKHOTNIKOVA ◽  
◽  
G. V. SANTALOVA ◽  
E. S. GASILINA ◽  
S. E. SHOROKHOV ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Cardiovascular Disorders ◽  
Acute Respiratory Diseases

OCCURRENCE OF THE RISKS FOR DEVELOPMENT OF RESPIRATORY DISEASES IN CHILDREN EXPOSED TO THE CHEMICAL FACTORS OF THE EXPOSURE OF ALUMINA REFINERY- ASSOCIATED BUSINESS ACTIVITY

2019 ◽  
pp. 42-47 ◽  
Author(s):  
M.A. Zemlianova ◽  
I.V. Tikhonova
Keyword(s):  
Respiratory Tract ◽  
Respiratory Diseases ◽  
Inflammatory Diseases ◽  
Allergic Inflammation ◽  
Respiratory Morbidity ◽  
Upper Respiratory Tract ◽  
Negative Effects ◽  
Wide Range ◽  
Chemical Factors ◽  
Chronic Lymphoproliferative Diseases

Alumina refineries are among the leading sources of atmospheric air pollution with a wide range of pollutants hazardous to human respiratory organs. It is relevant to study and evaluate the occurrence of the risks for development of respiratory diseases in children living in the area affected by the emission components of an alumina refinery. We assessed air quality of the area under observation and comparison according to monitoring observations, risk of non-carcinogenic effects from the respiratory organs. The content of chemicals in the blood and urine adequate to risk factors was quantified. The structure of individual groups of respiratory diseases was analyzed. The causal relationships of violations of laboratory parameters with an increased content of chemicals in biological media were evaluated. It was found that an aerogenic exposure of chemical pollutants is formed on the territory with the production of metallurgical alumina. It determines the risk for development of respiratory diseases, exceeding an acceptable level up to 49.9 times. In the exposed children, the content of manganese, chromium, nickel, copper, xylenes, formaldehyde and aluminum, fluoride ion in the urine was increased to 4.2 times in relation to the indices in the comparison group. A high level of additional respiratory morbidity(1.8 times) was revealed. Chronic lymphoproliferative diseases of the nasopharynx and inflammatory diseases of the upper respiratory tract (up to 6.6 times more often), inflammatory diseases with a predominance of the mechanism of allergic inflammation ( up to 2.1 times more often)are more often detected in the framework of the respiratory diseases. Negative effects on the part of the respiratory system in the form of activation of antioxidant processes, the development of an inflammatory reaction, local, general and specific sensitization of the respiratory tract were established. It confirms the occurrence of the risks for the development of respiratory diseases in children in the exposure area of the chemical factors of alumina refinery-associated economic activity.

scholarly journals Effect of Zinc Salts on Respiratory Syncytial Virus Replication

2004 ◽  
Vol 48 (3) ◽  
pp. 783-790 ◽  
Author(s):  
Rahaman O. Suara ◽  
James E. Crowe
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Zinc Acetate ◽  
Lower Respiratory Tract ◽  
Divalent Cations ◽  
Cell Monolayer ◽  
Inhibitory Effect ◽  
Plaque Formation ◽  
Zinc Salts ◽  
Syncytial Virus

ABSTRACT Zinc supplementation decreases the morbidity of lower respiratory tract infection in pediatric patients in the developing world. We sought to determine if zinc mediates a specific inhibitory effect against the major cause of pediatric lower respiratory tract disease, respiratory syncytial virus (RSV). We determined the in vitro inhibitory effect of three zinc salts (zinc acetate, lactate, and sulfate) on the replication of RSV at various concentrations of 10 and 1 mM and 100 and 10 μM. The degree of inhibition of RSV replication was examined in the presence of zinc during preincubation, adsorption, or penetration and was compared with that caused by salts of other divalent cations. Complete inhibition of RSV plaque formation was observed at 1 and 10 mM, representing reductions that were ≥106-fold. At the lowest concentration tested, 10 μM, we observed ≥1,000-fold reductions in RSV yield when zinc was present during preincubation, adsorption, penetration, or egress of virus. The therapeutic indices, determined as ratios of 50% toxicity concentration to 50% inhibitory concentration, were 100, 150, and 120 for zinc acetate, zinc lactate, and zinc sulfate, respectively. The inhibitory effect of zinc salts on RSV was concentration dependent and was not observed with other salts containing divalent cations such as calcium, magnesium, and manganese. RSV plaque formation was prevented by pretreatment of HEp-2 cell monolayer cultures with zinc or by addition of zinc to methylcellulose overlay media after infection. The results of this study suggest that zinc mediates antiviral activity on RSV by altering the ability of the cell to support RSV replication.

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