Rapid reversal of denervation supersenssitivity of dopamine D1 receptors by 1-dopa or a novel dopamamine D1 receptor agonist, A68930

One of the current hypotheses on dopamine in the physiology of motivation posits that this neurotransmitter regulates filtering and selection of inputs to the nucleus accumbens. The effects of dopamine (100 μM) and the D1-receptor agonist SKF 38393 (20–50 μM) on GABAergic synaptic transmission between pairs of principal cells of rat nucleus accumbens were studied by using simultaneous dual patch-clamp recordings in acutely prepared brain slices. Both compounds attenuated postsynaptic responses induced by presynaptic firing and this effect was reversed by the D1-receptor antagonist SCH 23390 (25 μM). This attenuating effect of dopamine D1-receptors may act to diminish competitive interactions between single projection neurons or ensembles in the nucleus accumbens.

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Regulation of dopamine D1 receptors by chronic administration of structurally different D1 receptor antagonist: A quantitative autoradiographic study

European Journal of Pharmacology ◽

10.1016/0014-2999(92)90671-p ◽

1992 ◽

Vol 210 (2) ◽

pp. 195-200 ◽

Cited By ~ 11

Author(s):

Jaakko Lappalainen ◽

Jarmo Hietala ◽

Tiina Pohjalainen ◽

Erkka Syvälahti

Keyword(s):

Receptor Antagonist ◽

Chronic Administration ◽

Autoradiographic Study ◽

D1 Receptor ◽

D1 Receptors ◽

Dopamine D1 Receptors ◽

D1 Receptor Antagonist

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Cell-type-specific modulation of behaviorally relevant and distracting stimuli by dopamine D1 receptors in primate prefrontal cortex

Intrinsic Activity ◽

10.25006/ia.4.s2-a14.7 ◽

2016 ◽

Vol 4 (Suppl. 2) ◽

pp. A14.7

Author(s):

Simon N. Jacob

Keyword(s):

Prefrontal Cortex ◽

D1 Receptors ◽

Cell Type ◽

Dopamine D1 Receptors ◽

Cell Type Specific

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Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)82397-3 ◽

1993 ◽

Vol 268 (20) ◽

pp. 14757-14763

Author(s):

M.D. Bates ◽

C.L. Olsen ◽

B.N. Becker ◽

F.J. Albers ◽

J.P. Middleton ◽

...

Keyword(s):

D1 Receptors ◽

Kidney Cells ◽

Dopamine D1 Receptors ◽

Down Regulation ◽

Camp Phosphodiesterase ◽

Opossum Kidney ◽

Endogenous Dopamine ◽

Opossum Kidney Cells ◽

In Cells

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Localization and function of dopamine receptors in the subthalamic nucleus of normal and parkinsonian monkeys

Journal of Neurophysiology ◽

10.1152/jn.00849.2013 ◽

2014 ◽

Vol 112 (2) ◽

pp. 467-479 ◽

Cited By ~ 22

Author(s):

Adriana Galvan ◽

Xing Hu ◽

Karen S. Rommelfanger ◽

Jean-Francois Pare ◽

Zafar U. Khan ◽

...

Keyword(s):

Dopamine Receptors ◽

Subthalamic Nucleus ◽

Receptor Agonist ◽

Rhesus Macaques ◽

Extracellular Recording ◽

Receptor Activation ◽

D1 Receptors ◽

Substantia Nigra Pars Compacta ◽

D1 And D2 Receptors ◽

And Function

The subthalamic nucleus (STN) receives a dopaminergic innervation from the substantia nigra pars compacta, but the role of this projection remains poorly understood, particularly in primates. To address this issue, we used immuno-electron microscopy to localize D1, D2, and D5 dopamine receptors in the STN of rhesus macaques and studied the electrophysiological effects of activating D1-like or D2-like receptors in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian monkeys. Labeling of D1 and D2 receptors was primarily found presynaptically, on preterminal axons and putative glutamatergic and GABAergic terminals, while D5 receptors were more significantly expressed postsynaptically, on dendritic shafts of STN neurons. The electrical spiking activity of STN neurons, recorded with standard extracellular recording methods, was studied before, during, and after intra-STN administration of the dopamine D1-like receptor agonist SKF82958, the D2-like receptor agonist quinpirole, or artificial cerebrospinal fluid (control injections). In normal animals, administration of SKF82958 significantly reduced the spontaneous firing but increased the rate of intraburst firing and the proportion of pause-burst sequences of firing. Quinpirole only increased the proportion of such pause-burst sequences in STN neurons of normal monkeys. In MPTP-treated monkeys, the D1-like receptor agonist also reduced the firing rate and increased the proportion of pause-burst sequences, while the D2-like receptor agonist did not change any of the chosen descriptors of the firing pattern of STN neurons. Our data suggest that dopamine receptor activation can directly modulate the electrical activity of STN neurons by pre- and postsynaptic mechanisms in both normal and parkinsonian states, predominantly via activation of D1 receptors.

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