scholarly journals Metabolic regulation of steroidogenesis in isolated adrenal and adrenocortical carcinoma cells of rat. Effect of adrenocorticotropic hormone and adenosine cyclic 3′: 5′-monophosphate on the plasma membrane

FEBS Letters ◽  
1974 ◽  
Vol 38 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Rameshwar K. Sharma ◽  
Lynda Sutliff
Keyword(s):  
Plasma Membrane ◽  
Adrenocortical Carcinoma ◽  
Metabolic Regulation ◽  
Adrenocorticotropic Hormone ◽  
Carcinoma Cells

A Case of Myxoid Adrenocortical Carcinoma With Extensive Lipomatous Metaplasia

2003 ◽  
Vol 127 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Miki Izumi ◽  
Hiromi Serizawa ◽  
Keiichi Iwaya ◽  
Kazuhiro Takeda ◽  
Hironobu Sasano ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adrenocortical Carcinoma ◽  
Adrenal Tumor ◽  
Carcinoma Cells ◽  
Peculiar Feature ◽  
Radiographic Examination ◽  
Rare Phenomenon ◽  
Cut Surface ◽  
Vacuolated Cytoplasm ◽  
Lipomatous Metaplasia

Abstract We report a combination of unusual myxoid change and extensive lipomatous metaplasia of an adrenocortical carcinoma. The patient was a 38-year-old man with hypertension and heart failure. Radiographic examination revealed the presence of a left adrenal tumor, and adrenalectomy was performed. The tumor weighed 380 g and appeared encapsulated. The cut surface was predominantly gelatinous. Histologically, the tumor was composed of atypical round cells with eosinophilic to vacuolated cytoplasm. The tumor was diagnosed as adrenocortical carcinoma. The stroma accumulated copious mucinous material. In addition, individual to nodular mature adipocytes were admixed throughout the tumor. The transition from carcinoma cells to mature adipocytes was recognized. Myxoid change is a very rare phenomenon in adrenocortical carcinoma, and only 10 similar cases have been reported to date. Lipomatous metaplasia is another peculiar feature of adrenocortical lesions that has been reported only in benign conditions. To our knowledge, this is the first reported case of adrenocortical carcinoma with lipomatous metaplasia.

scholarly journals Differentiation potential to neural-like cells in human adrenocortical carcinoma SW-13 cells

2019 ◽  
Author(s):  
Eriko Shimada ◽  
Yusuke Tsuruwaka
Keyword(s):  
Early Diagnosis ◽  
Adrenal Gland ◽  
Cancer Cells ◽  
Adrenocortical Carcinoma ◽  
Neural Differentiation ◽  
Neural Induction ◽  
Carcinoma Cells ◽  
Rare Cancer ◽  
Differentiation Potential ◽  
Aggressive Tumor

Various cancer cells are known to show neural differentiation. Adrenocortical carcinoma (ACC) is a rare and frequently aggressive tumor originating in the cortex of the adrenal gland. Early diagnosis of ACC is challenging due to a lot of unknown aspects such as cell characteristics in a rare cancer. In the present study, morphological features were examined in the adrenal cortex carcinoma cells SW-13 as an initial candidate, which were exposed to neural differentiation condition. SW-13 cells treated with the neural induction supplement showed neural-like differentiation with elongated filaments. It was suggested that SW-13 cells had neural differentiation potential and could be a research tool to elucidate the cell characteristics in future ACC studies.

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