A versatile computational method for the determination of areas under the curve and moment curve following multidose drug administration

1988 ◽  
Vol 23 (3-4) ◽  
pp. 239-249 ◽  
Author(s):  
Toyoko S Yamashita ◽  
Hwei-Ling Lee ◽  
Michael D. Reed
Keyword(s):  
Drug Administration ◽  
Computational Method ◽  
Moment Curve

An experimental evaluation of simplified procedures for determining the proton spin–lattice relaxation rates of natural products

1980 ◽  
Vol 58 (19) ◽  
pp. 2016-2023 ◽  
Author(s):  
Lawrence D. Colebrook ◽  
Laurance D. Hall
Keyword(s):  
Natural Products ◽  
Lattice Relaxation ◽  
Null Point ◽  
Proton Spin ◽  
Computational Method ◽  
Spin Lattice Relaxation ◽  
Relaxation Rates ◽  
Spin Lattice ◽  
Simplified Procedures

A general discussion is given of the determination of the proton spin–lattice relaxation rates of natural products, with particular emphasis on use of the null-point method which, for the systems studied here, gives identical results with those obtained via the conventional (and relatively time consuming) computational method.

scholarly journals Estimate of FDG Excretion by means of Compartmental Analysis and Ant Colony Optimization of Nuclear Medicine Data

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Sara Garbarino ◽  
Giacomo Caviglia ◽  
Massimo Brignone ◽  
Michela Massollo ◽  
Gianmario Sambuceti ◽  
...  
Keyword(s):  
Ant Colony Optimization ◽  
Fdg Pet ◽  
Final Section ◽  
Synthetic Data ◽  
Compartmental Analysis ◽  
Ant Colony ◽  
Computational Method ◽  
Positron Emission ◽  
Glycolytic Activity

[18F]fluoro-2-deoxy-D-glucose (FDG) is one of the most utilized tracers for positron emission tomography (PET) applications in oncology. FDG-PET relies on higher glycolytic activity in tumors compared to normal structures as the basis of image contrast. As a glucose analog, FDG is transported into malignant cells which typically exhibit an increased radioactivity. However, different from glucose, FDG is not reabsorbed by the renal system and is excreted to the bladder. The present paper describes a novel computational method for the quantitative assessment of this excretion process. The method is based on a compartmental analysis of FDG-PET data in which the excretion process is explicitly accounted for by the bladder compartment and on the application of an ant colony optimization (ACO) algorithm for the determination of the tracer coefficients describing the FDG transport effectiveness. The validation of this approach is performed by means of both synthetic data and real measurements acquired by a PET device for small animals (micro-PET). Possible oncological applications of the results are discussed in the final section.

scholarly journals Evaluation of Tertiary Butylhydroquinone as an Antioxidant in Powdered Roasted Peanuts Products1

1979 ◽  
Vol 6 (1) ◽  
pp. 55-57 ◽  
Author(s):  
M. W. Hoover ◽  
P. N. Painter
Keyword(s):  
Quantitative Determination ◽  
Shelf Life ◽  
Arachis Hypogaea ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Fat Content ◽  
Tertiary Butylhydroquinone ◽  
Life Study ◽  
Arachis Hypogaea L

Abstract A fifteen month shelf life study was conducted to determine the effectiveness of tertiary butylhydroquinone (TBHQ) as an antioxidant in products made from roasted peanuts (Arachis hypogaea L.). Five levels of TBHQ were studied, 0.0%, 0.01%, 0.02%, 0.03%, and 0.04% based on the fat content of the peanuts. Total carbonyl assays performed monthly served as indices of rancidity. Results indicate that the shelf life of the product may be extended up to thirteen months using the 0.02% level of TBHQ now allowed by the Food and Drug Administration. In addition, the quantitative determination of total carbonyls proved to be an acceptable indicator of rancidity of roasted peanuts.

Food and Drug Administration: Approach to Evaluating Neurotoxicity

1989 ◽  
Vol 5 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Thomas J. Sobotka
Keyword(s):  
Drug Administration ◽  
Safety Assessment ◽  
Food And Drug Administration ◽  
Food Additives ◽  
Current Approach ◽  
Chemical Safety ◽  
Toxicological Profile ◽  
Intended Use

One of the primary features of the mission of the Food and Drug Administration is to assure with reasonable certainty that no harm will result from the intended use of chemicals added to food. In carrying out this mission the FDA uses a structured process to assess the safety of each food chemical. The detailed mechanics of this process are described in an FDA document entitled “Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Use in Food” (Food and Drug Administration, 1982). Central to its evaluation the FDA requires a collective set of information, including estimates of the anticipated human exposure to the food chemical and a broad-based toxicological profile. Certainly, any adverse effect observed in the nervous system is recognized as an important element in the determination of chemical safety and follow-up information which would enable an assessment of such an effect to be included in the toxicological profile. The agency's current approach to evaluating neurotoxicity should be viewed within the context of its overall strategy for the safety assessment of food chemicals. Four basic premises underlie the FDA's approach to safety assessment.

A computational method for the determination of the response of a linear system

1987 ◽  
Vol 112 (1) ◽  
pp. 183-186 ◽  
Author(s):  
R.E. Mickens ◽  
K. Oyedeji ◽  
K.R. Speight
Keyword(s):  
Linear System ◽  
Computational Method
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