Diastolic function of the left ventricle in the reperfused donor heart following 6 hours preservation

1992 ◽  
Vol 24 ◽  
pp. 159
Author(s):  
Toshizumi Shirai ◽  
Makoto Sunamori ◽  
Akio Suzuki
Keyword(s):  
Left Ventricle ◽  
Diastolic Function ◽  
Donor Heart

scholarly journals AB0249 POSITIVE EFFECT OF ANTIRHEUMATIC THERAPY ON THE COURSE OF CHRONIC HEART FAILURE IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1424.3-1425
Author(s):  
I. Kirillova ◽  
D. Novikova ◽  
T. Popkova ◽  
Y. Gorbunova ◽  
E. Markelova ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Left Ventricle ◽  
Disease Activity ◽  
Diastolic Function ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Antirheumatic Therapy ◽  
Early Ra ◽  
Lv Diastolic Function

Background:Objectives:to evaluate the effect of antirheumatic therapy according to the “treat to target” strategy on the course of chronic heart failure (CHF) in patients with early RA.Methods:The study included 22 patients CHF with valid diagnosis of RA (criteria ACR / EULAR, 2010), 17 (77%) of women, median (Me) age - 60 years, Me disease duration - 7 months; IgM seropositive for rheumatoid factor 10 (45%) and / or antibodies to the cyclic citrulline peptide 22 (100%), DAS28-5.6 [4,8;6,5]. CHF verified in accordance the recommendations for the diagnosis and treatment of CHF Society of Specialists in Heart Failure (2013). The concentration of NT-proBNP was determined by electrochemiluminescence. For all patients was started methotrexate (MT) therapy with a rapid increase in the dose to 30 mg per week subcutaneously. If the MT was not effective enough, after 3 months a biological Disease-Modifying Anti-Rheumatic Drug (bDMARDs) was added to the therapy, predominantly TNF-alpha inhibitors. After 18 months, 10 (45%) patients were in remission and low disease activity, 6 (60%) of patients underwent MT therapy in combination with bDMARDs.Results:In baseline CHF with preserved EF was revealed in 21 (95%) patients, in 1 patient - CHF with reduced EF. After 18 months there was a positive dynamics of improvement of clinical symptoms, echocardiographic indicators (decrease the size of the left atrium (LА) and the index of end-systolic volume of LА, IVRT, E’ LV), diastolic function of the left ventricle (LV). There was no decompensation of CHF. LV diastolic function normalized in 7 (32%) patients who reached the target level of blood pressure, remission (n = 5) and low (n = 2) disease activity, mainly in the treatment of MT and bDMARDs. In patients with RA and CHF, the level of NT-proBNP decreased from 192.2 [151.4; 266.4] to 114.0 [90.4; 163.4] pg / ml (p <0.001), normalized in 16 of 22 (73%) patients (p <0.001) with remission or low RA activity. In 5 (22%) patients, the clinical manifestations of CHF regressed, LV diastolic function and NT-proBNP level normalized.Conclusion:In patients with early RA and CHF anti-rheumatic therapy improves the clinical course of CHF. There were an improvement in the clinical course of CHF, diastolic function of the left ventricle and a decrease in NT-proBNP.Disclosure of Interests:None declared

scholarly journals FEATURES OF LEFT VENTRICLE DIASTOLIC FUNCTION IN PATIENTS WITH NON Q-WAVE MYOCARDIAL INFARCTION AFTER PERCUTANEOUS INTERVENTION

2017 ◽  
Vol 9 (2) ◽  
pp. 44-50
Author(s):  
D A Khomyakova ◽  
S A Sayganov ◽  
Y N Grishkin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Left Ventricle ◽  
Diastolic Function ◽  
Percutaneous Intervention ◽  
Infarct Related Artery ◽  
Group 2 ◽  
Grade 3 ◽  
Higher Sensitivity ◽  
Q Wave

Aim: To make natural development more exact to state the value of scientific prognostication of dia- stolic dysfunction with acute myocardial infarction without Q-wave after percutaneous intervention.materials and methods: 95 patients were subjected to coronography and revascularization of in- farct-related artery. The patients were divided into 2 groups depending on angiographic results with single and multivessel affection. during first 48 hours from the beginning of the disease they were under ECHO examination.Results: Left ventricle affections dF data were revealed relatively to heaviness of affection in cor- onary vessels without reliable differences in local and global contractility. Primordialy the 1 group contained 14 (54%) patients of I grade dd, 5 (19%) with II grade, 1 (8%) with III grade, 6 (19%) without dd. A year later: 18 (70%) with I grade dd, 3 (12%) with II, patients with III grade were not redictered, 5 (18%) without dd. In group 2 within first 48 hours 37 (54%) patients had I grade,25 (36%) II grade, 7 (10%) III grade. In a year there were 46 (67%) with I grade, 13 (19%) II grade, 3 (4%) with III grade dd, 7 (10%) without dd.Conclusions: Obtained data indicate of a higher sensitivity dependently dF ischemia.In contrast to myocardial infarction group with coronary bloodstream fully restored within short terms, in group with multivessel affections a more heavy dd data preserved longer, in spite of infarct related artery revascularization. Also unfavourable events were revealed.

scholarly journals Quantitation of mitral annular oscillations and longitudinal “ringing” of the left ventricle: a new window into longitudinal diastolic function

2006 ◽  
Vol 100 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Matt M. Riordan ◽  
Sándor J. Kovács
Keyword(s):  
Left Ventricle ◽  
Diastolic Function ◽  
Elastic Strain ◽  
Fluid Motion ◽  
Harmonic Oscillation ◽  
Mitral Annulus ◽  
Left Ventricular ◽  
Contour Shape ◽  
Left Ventricular Stiffness ◽  
Early Filling

For diastolic function (DF) quantification, transmitral flow velocity has been characterized in terms of the geometric features of a triangle (heights, widths, areas, durations) approximating the E-wave contour, whereas mitral annular velocity has only been characterized by E′-wave peak amplitude. The fact that E-waves convey global DF information, whereas annular E′-waves provide longitudinal DF information, has not been fully characterized, nor has the physiological legitimacy of combining fluid motion (E)- and tissue motion (E′)-derived measurements into routinely used indexes (E/E′) been fully elucidated. To place these Doppler echo measurements on a firmer causal, physiological, and clinical basis, we examined features of the E′-wave (and annular motion in general), including timing, amplitude, duration, and contour (shape), in kinematic terms. We derive longitudinal rather than global indexes of stiffness and relaxation of the left ventricle and explain the observed difference between E- and E′-wave durations. On the basis of the close agreement between model prediction and E′-wave contour for subjects having normal physiology, we propose damped harmonic oscillation as the proper paradigm in which to view and analyze the motion of the mitral annulus during early filling. Novel, longitudinal indexes of left ventricular stiffness, relaxation, viscosity, and stored (end-systolic) elastic strain can be determined from the E′-wave (and any subsequent waves) by modeling annular motion during early filling as damped harmonic oscillation. A subgroup exploratory analysis conducted in diabetic subjects ( n = 9) and nondiabetic controls ( n = 12) indicates that longitudinal DF indexes differentiate between these groups on the basis of longitudinal damping ( P < 0.025) and longitudinal stored elastic strain ( P < 0.005).

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