Adenosine (ADO) increases oxygen utilization efficiency in hypoxemia-perfused myocardium*1

1992 ◽  
Vol 24 ◽  
pp. S8
Author(s):  
S LEE
1988 ◽  
Vol 20 (4-5) ◽  
pp. 101-108 ◽  
Author(s):  
R. C. Clifft ◽  
M. T. Garrett

Now that oxygen production facilities can be controlled to match the requirements of the dissolution system, improved oxygen dissolution control can result in significant cost savings for oxygen activated sludge plants. This paper examines the potential cost savings of the vacuum exhaust control (VEC) strategy for the City of Houston, Texas 69th Street Treatment Complex. The VEC strategy involves operating a closed-tank reactor slightly below atmospheric pressure and using an exhaust apparatus to remove gas from the last stage of the reactor. Computer simulations for one carbonaceous reactor at the 69th Street Complex are presented for the VEC and conventional control strategies. At 80% of design loading the VEC strategy was found to provide an oxygen utilization efficiency of 94.9% as compared to 77.0% for the conventional control method. At design capacity the oxygen utilization efficiency for VEC and conventional control was found to be 92.3% and 79.5%, respectively. Based on the expected turn-down capability of Houston's oxygen production faciilities, the simulations indicate that the VEC strategy will more than double the possible cost savings of the conventional control method.


2021 ◽  
Vol 12 (11) ◽  
Author(s):  
Ruzhou Zhao ◽  
Xingcheng Zhao ◽  
Xiaobo Wang ◽  
Yanqi Liu ◽  
Jie Yang ◽  
...  

AbstractRapid adaptation to a hypoxic environment is an unanswered question that we are committed to exploring. At present, there is no suitable strategy to achieve rapid hypoxic adaptation. Here, we demonstrate that fasting preconditioning for 72 h reduces tissue injuries and maintains cardiac function, consequently significantly improving the survival rates of rats under extreme hypoxia, and this strategy can be used for rapid hypoxic adaptation. Mechanistically, fasting reduces blood glucose and further suppresses tissue mTOR activity. On the one hand, fasting-induced mTOR inhibition reduces unnecessary ATP consumption and increases ATP reserves under acute hypoxia as a result of decreased protein synthesis and lipogenesis; on the other hand, fasting-induced mTOR inhibition improves mitochondrial oxygen utilization efficiency to ensure ATP production under acute hypoxia, which is due to the significant decrease in ROS generation induced by enhanced mitophagy. Our findings highlight the important role of mTOR in acute hypoxic adaptation, and targeted regulation of mTOR could be a new strategy to improve acute hypoxic tolerance in the body.


2019 ◽  
Vol 33 (10) ◽  
pp. 11443-11457 ◽  
Author(s):  
Jeejabai Radhakrishnan ◽  
Alvin Baetiong ◽  
Harrison Kaufman ◽  
Michelle Huynh ◽  
Angela Leschinsky ◽  
...  

1991 ◽  
Vol 52 (5) ◽  
pp. 1063-1068 ◽  
Author(s):  
Satoshi Furukawa ◽  
Gerhard Kreiner ◽  
Joseph E. Bavaria ◽  
James T. Streicher ◽  
L.Henry Edmunds

2020 ◽  
Vol 3 (2) ◽  
pp. e200149
Author(s):  
Kiran Kumar Balegar V ◽  
Madhuka Jayawardhana ◽  
Andrew J. Martin ◽  
Philip de Chazal ◽  
Ralph K. H. Nanan

2020 ◽  
Vol 472 (11) ◽  
pp. 1619-1630
Author(s):  
Ru-Zhou Zhao ◽  
Xiao-Bo Wang ◽  
Shuai Jiang ◽  
Ning-Yu Ru ◽  
Bo Jiao ◽  
...  

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