Studies on neurotransmitter markers and neuronal cell density in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy

1985 ◽  
Vol 71 (2-3) ◽  
pp. 193-208 ◽  
Author(s):  
Ichiro Kanazawa ◽  
Shin Kwak ◽  
Hidenao Sasaki ◽  
Hidehiro Mizusawa ◽  
Osamu Muramoto ◽  
...  
Keyword(s):  
Cell Density ◽  
Cerebellar Atrophy ◽  
Neuronal Cell ◽  
Olivopontocerebellar Atrophy ◽  
Cortical Cerebellar Atrophy

scholarly journals MRI CNS Atrophy Pattern and the Etiologies of Progressive Ataxias

2021 ◽  
Author(s):  
Mario Mascalchi
Keyword(s):  
Cerebellar Atrophy ◽  
Olivopontocerebellar Atrophy ◽  
Volume Loss ◽  
Cellular Targets ◽  
Inherited Ataxias ◽  
Genetic Assessment ◽  
Cortical Cerebellar Atrophy

MRI shows in-vivo the three archetypal patterns of CNS volume loss underlying progressive ataxias, namely spinal atrophy (SA), cortical cerebellar atrophy (CCA) and olivopontocerebellar atrophy (OPCA). The MRI-based CNS atrophy pattern was reviewed in 128 progressive ataxias. A CNS atrophy pattern was identified in 91 conditions: SA in Freidreich’s ataxia, CCA in 5 acquired and 72 (24 dominant, 47 recessive,1 X-linked) inherited ataxias, OPCA in Multi-System Atrophy and 12 (9 dominant, 2 recessive,1 X-linked) inherited ataxias. The MRI-based CNS atrophy pattern may be useful for genetic assessment, identification of shared cellular targets, and repurposing therapies or enlargement of drugs indications in progressive ataxias.

Reduced brain electric activities of frontal lobe in cortical cerebellar atrophy

2003 ◽  
Vol 114 (4) ◽  
pp. 740-747 ◽  
Author(s):  
Mio Arai ◽  
Hideaki Tanaka ◽  
Roberto D Pascual-Marqui ◽  
Koichi Hirata
Keyword(s):  
Frontal Lobe ◽  
Cerebellar Atrophy ◽  
Cortical Cerebellar Atrophy

scholarly journals Dynamic Cerebrospinal Fluid Flow on MRI in Cortical Cerebellar Atrophy and Multiple System Atrophy-cerebellar Type

2015 ◽  
Vol 54 (14) ◽  
pp. 1717-1723 ◽  
Author(s):  
Yusuke Fukui ◽  
Nozomi Hishikawa ◽  
Kota Sato ◽  
Syoichiro Kono ◽  
Kosuke Matsuzono ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Fluid Flow ◽  
Multiple System Atrophy ◽  
Cerebellar Atrophy ◽  
Cerebrospinal Fluid Flow ◽  
Cerebellar Type ◽  
Cortical Cerebellar Atrophy

Cortical Cerebellar Atrophy without Ataxia

1946 ◽  
Vol 5 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Ben W. Lichtenstein ◽  
Samuel A. Levinson
Keyword(s):  
Cerebellar Atrophy ◽  
Cortical Cerebellar Atrophy

PARENCHYMATOUS CORTICAL CEREBELLAR ATROPHY (CHRONIC ATROPHY OF PURKINJE'S CELLS)

Brain ◽  
1933 ◽  
Vol 56 (2) ◽  
pp. 191-212 ◽  
Author(s):  
H. L. PARKER ◽  
J. W. KERNOHAN
Keyword(s):  
Cerebellar Atrophy ◽  
Cortical Cerebellar Atrophy

Acoustic Analysis of Vocal Instability in Cerebellar Dysfunctions

1994 ◽  
Vol 103 (2) ◽  
pp. 98-104 ◽  
Author(s):  
Hermann Ackermann ◽  
Wolfram Ziegler
Keyword(s):  
Acoustic Analysis ◽  
Cerebellar Atrophy ◽  
Motor Deficits ◽  
Olivopontocerebellar Atrophy ◽  
Normal Range ◽  
Pitch Level ◽  
Vocal Effort ◽  
Cortical Dysfunction ◽  
Asymmetrically Distributed ◽  
Respiratory Reflexes

Acoustic analysis of vocal instability during the production of isolated vowels, including computation of mean fundamental frequency (F0), period-to-period variability (jitter), pitch fluctuations, and between-trial variation of F0, was performed in 20 patients with cerebellar cortical dysfunction. Eleven subjects suffered from purely cerebellar atrophy (CA). In the remaining 9 patients olivopontocerebellar atrophy (OPCA) had been diagnosed. A subgroup of both the CA and OPCA subjects presented with enlarged pitch fluctuations and/or increased jitter values. It is conceivable that asymmetrically distributed motor deficits at the laryngeal level and altered gain settings of laryngeal and/or respiratory reflexes account for the observed phonatory instability. Moreover, 5 of the 20 cerebellar patients had a pitch level exceeding the upper limit of the normal range. Presumably, this deviation reflects increased vocal effort.

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