A Multiparametric MR-Based RadioFusionOmics Model with Robust Capabilities of Differentiating Glioblastoma Multiforme from Solitary Brain Metastasis

This study aimed to evaluate the diagnostic potential of a novel RFO model in differentiating GBM and SBM with multiparametric MR sequences collected from 244 (131 GBM and 113 SBM) patients. Three basic volume of interests (VOIs) were delineated on the conventional axial MR images (T1WI, T2WI, T2_FLAIR, and CE_T1WI), including volumetric non-enhanced tumor (nET), enhanced tumor (ET), and peritumoral edema (pTE). Using the RFO model, radiomics features extracted from different multiparametric MRI sequence(s) and VOI(s) were fused and the best sequence and VOI, or possible combinations, were determined. A multi-disciplinary team (MDT)-like fusion was performed to integrate predictions from the high-performing models for the final discrimination of GBM vs. SBM. Image features extracted from the volumetric ET (VOIET) had dominant predictive performances over features from other VOI combinations. Fusion of VOIET features from the T1WI and T2_FLAIR sequences via the RFO model achieved a discrimination accuracy of AUC = 0.925, accuracy = 0.855, sensitivity = 0.856, and specificity = 0.853, on the independent testing cohort 1, and AUC = 0.859, accuracy = 0.836, sensitivity = 0.708, and specificity = 0.919 on the independent testing cohort 2, which significantly outperformed three experienced radiologists (p = 0.03, 0.01, 0.02, and 0.01, and p = 0.02, 0.01, 0.45, and 0.02, respectively) and the MDT-decision result of three experienced experts (p = 0.03, 0.02, 0.03, and 0.02, and p = 0.03, 0.02, 0.44, and 0.03, respectively).

Identification of best discrimination surface by mixed-integer semi-definite programming for support vector machine

This paper proposes two improvements to the support vector machine (SVM): (i) extension to a semi-positive definite quadratic surface, which improves the discrimination accuracy; (ii) addition of a variable selection constraint. However, this model is formulated as a mixed-integer semi-definite programming (MISDP) problem, and it cannot be solved easily. Therefore, we propose a heuristic algorithm for solving the MISDP problem efficiently and show its effectiveness by using corporate credit rating data.

Improving Discriminating Accuracy Rate of DDoS Attacks and Flash Events

Internet security has become a big issue with the passage of time. Among many threats, the distributed denial-of-service (DDoS) attack is the most frequent threat in the networks. The purpose of the DDoS attacks is to interrupt service availability provided by different web servers. This results in legitimate users not being able to access the servers and hence facing denial of services. On the other hand, flash events are a high amount of legitimate users visiting a website due to a specific event. Consequences of these attacks are more powerful when launched during flash events, which are legitimate traffic and cause a denial of service. The purpose of this study is to build an intelligent network traffic classification model to improve the discrimination accuracy rate of DDoS attacks from flash events traffic. Weka is adopted as the platform for evaluating the performance of a random forest algorithm.

Effect of lacto-fermentation and freeze-drying on the quality of beetroot evaluated using machine vision and sensory analysis

This study was aimed at evaluating the effect of freeze-drying and lacto-fermentation on the texture parameters of images and sensory attributes of beetroots. The samples were imaged using a flatbed scanner, and textures from images converted to color channels L, a, b, R, G, B, X, Y, Z were computed. The discrimination of raw and processed beetroots was performed using models based on textures selected for each color channel. The sensory quality of processed samples was determined using the attributes related to smell, color, texture and taste. The highest discrimination accuracy of 97.25% was obtained for the model built for color channel b. The accuracies for other channels were equal to 96.25% for channel a, 95.25% for channel R, 95% for channel Y, 94.75% for channel B, 94.5% for channel X, 94% for channel L, 92.5% for channel G, 88.25% for channel Z. In the case of some models, the raw and lacto-fermented beetroots were discriminated with 100% correctness. The freeze-dried and freeze-dried lacto-fermented samples were also the most similar in terms of sensory attributes, such as off-odor, attractiveness color, beetroot color, crunchiness, hardness, bitter taste, overall quality. The results indicated that the image parameters and sensory attributes may be related.

A New System of Cantonese one? Tone Perception and Production in Hong Kong South Asian Cantonese

Studies in language contact have identified many instances of linguistic variation and grammatical innovations introduced by speakers from multi-ethnic urban neighborhoods. This study focuses on the variety of Cantonese spoken by South Asian youths in Hong Kong, specifically their production and perception of Hong Kong Cantonese tones. Our findings show that the South Asian Cantonese speakers have a smaller tonal inventory than the canonical six-tone system of standard Hong Kong Cantonese and their tonal discrimination abilities are also more impoverished relative to their ethnic Chinese peers. Further analysis shows a positive correlation between tonal discrimination accuracy and tonal realization distinctness among the South Asian speakers, but not among the ethnic Chinese. These findings suggest that South Asian Cantonese speakers might have developed a distinct tone system from their ethnic Chinese peers.

Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions

Sensory responses of cortical neurons are more discriminable when evoked on a baseline of desynchronized spontaneous activity, but cortical desynchronization has not generally been associated with more accurate perceptual decisions. Here we show that mice perform more accurate auditory judgements when activity in the auditory cortex is elevated and desynchronized before stimulus onset, but only if the previous trial was an error, and that this relationship is occluded if previous outcome is ignored. We confirmed that the outcome-dependent effect of brain state on performance is neither due to idiosyncratic associations between the slow components of either signal, nor to the existence of specific cortical states evident only after errors. Instead, errors appear to gate the effect of cortical state fluctuations on discrimination accuracy. Neither facial movements nor pupil size during the baseline were associated with accuracy, but they were predictive of measures of responsivity, such as the probability of not responding to the stimulus or of responding prematurely. These results suggest that the functional role of cortical state on behavior is dynamic and constantly regulated by performance monitoring systems.