Food intake: Regulation by plasma amino acid pattern

Diet selection by control and hypothalamic–hyperphagic rats was recorded to examine the hypothesis that the plasma amino acid pattern may act as a satiety signal with respect to the decreased food intake associated with amino acid unbalanced diets. Rats were offered choices between: (a) protein-free and imbalanced diets; (b) imbalanced and corrected diets; (c) corrected and basal diets. Although selection by control and operated rats differed with respect to choice a, selection behaviors were comparable for choices b and c. Plasma amino acid patterns were similar in control and operated rats indicating that the same potential satiety signal was present in both groups. Since the "satiety center" was ablated in operated rats, it would seem that if plasma amino acid patterns serve as a satiety signal, this signal must act in some manner other than on the ventromedial area of the hypothalamus.

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Carotid or jugular amino acid infusions and food intake in the cockerel

British Journal Of Nutrition ◽

10.1079/bjn19790022 ◽

1979 ◽

Vol 41 (1) ◽

pp. 157-162 ◽

Cited By ~ 28

Author(s):

G. Tobin ◽

K. N. Boorman

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Food Intake ◽

Carotid Arteries ◽

Marked Effect ◽

Protein Diet ◽

Jugular Veins ◽

Low Protein ◽

Food Intake Regulation ◽

Intake Regulation

1. Infusions of histidine into the carotid arteries of cockerels receiving a histidine-limiting, imbalanced diet caused an increase in food intake, whereas similar infusions into the jugular veins did not.2. Infusions of lysine into the carotid arteries or jugular veins of young cockerels receiving a balanced, low-protein diet caused decreases in food intake. There was evidence of a more marked effect of carotid infusion.3. The mechanisms of food intake regulation by amino acids in mammals are applicable to birds and excesses of single amino acids do seem to affect food intake directly.

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Amino Acid Balance and Food Intake: Effect of Different Dietary Amino Acid Patterns on the Plasma Amino Acid Pattern of Rats

Journal of Nutrition ◽

10.1093/jn/100.4.429 ◽

1970 ◽

Vol 100 (4) ◽

pp. 429-437 ◽

Cited By ~ 26

Author(s):

Y. Peng ◽

A. E. Harper

Keyword(s):

Amino Acid ◽

Food Intake ◽

Amino Acid Pattern ◽

Plasma Amino Acid ◽

Dietary Amino Acid ◽

Amino Acid Balance

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Effect of Cortisol on Growth, Food Intake, Dietary Preference and Plasma Amino Acid Pattern of Rats Fed Amino Acid Imbalanced Diets

Journal of Nutrition ◽

10.1093/jn/96.1.139 ◽

1968 ◽

Vol 96 (1) ◽

pp. 139-151 ◽

Cited By ~ 8

Author(s):

Philip M.-B. Leung ◽

Quinton R. Rogers ◽

A. E. Harper

Keyword(s):

Amino Acid ◽

Food Intake ◽

Amino Acid Pattern ◽

Plasma Amino Acid ◽

Dietary Preference

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Effect of dietary amino acid pattern on plasma amino acid pattern and food intake

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1963.204.4.686 ◽

1963 ◽

Vol 204 (4) ◽

pp. 686-690 ◽

Cited By ~ 30

Author(s):

Juan C. Sanahuja ◽

Alfred E. Harper

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Food Intake ◽

Amino Acid Mixture ◽

Amino Acid Pattern ◽

Plasma Amino Acid ◽

Acid Mixture ◽

Dietary Amino Acid ◽

Indispensable Amino Acids ◽

Amino Acid Imbalance

Effects of a dietary imbalance of amino acids on the plasma amino acid pattern of the protein-depleted rat are described. The amino acid imbalance was created by adding a mixture of indispensable amino acids lacking histidine to a diet in which the protein was provided by 6% of beef blood fibrin. The addition of this amino acid mixture was previously shown to cause depressions in growth and food intake. In the present study the depression in food intake was preceded by a fall in plasma histidine concentration and at the same time the concentrations of some of the other indispensable amino acids, especially threonine, began to rise. The ratios of several indispensable amino acids to histidine in the plasma were elevated when food intake was most severely depressed.

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