The effect of hydroxyurea and mitomycin C on sperm motility in mice

Author(s):  
Gyula Ficsor ◽  
Leonard C. Ginsberg
Keyword(s):  
1984 ◽  
Vol 6 (3) ◽  
pp. 287-298 ◽  
Author(s):  
Gyula Ficsor ◽  
Gregory M. Oldford ◽  
Karen R. Loughlin ◽  
Brahma B. Panda ◽  
Janice L. Dubien ◽  
...  

1985 ◽  
Vol 4 (4) ◽  
pp. 461-464 ◽  
Author(s):  
C.Y. Hong ◽  
B.N. Chiang ◽  
J. Ku ◽  
P. Wu

1 The in vitro sperm-immobilizing effect of seven anticancer agents, namely cyclophosphamide, 5-fluorouracil, cytarabine, mitomycin-C, 6-mercaptopurine, doxorubicin and vinblastine were screened with a transmembrane migration method. 2 Only doxorubicin and vinblastine inhibited human sperm motility. 3 Because colchicine, a microtubular inhibitor, had no sperm-immobilizing effect, we suggest that the sperm membrane is the site of action of these two anticancer drugs to inhibit human sperm motility.


Author(s):  
Ezzatollah Keyhani ◽  
Larry F. Lemanski ◽  
Sharon L. Lemanski

Energy for sperm motility is provided by both glycolytic and respiratory pathways. Mitochondria are involved in the latter pathway and conserve energy of substrate oxidation by coupling to phosphorylation. During spermatogenesis, the mitochondria undergo extensive transformation which in many species leads to the formation of a nebemkem. The nebemkem subsequently forms into a helix around the axial filament complex in the middle piece of spermatozoa.Immature spermatozoa of axolotls contain numerous small spherical mitochondria which are randomly distributed throughout the cytoplasm (Fig. 1). As maturation progresses, the mitochondria appear to migrate to the middle piece region where they become tightly packed to form a crystalline-like sheath. The cytoplasm in this region is no longer abundant (Fig. 2) and the plasma membrane is now closely apposed to the outside of the mitochondrial layer.


2007 ◽  
Vol 177 (4S) ◽  
pp. 519-519
Author(s):  
Ofer Nativ ◽  
Renzo Colombo ◽  
Dov Engelstein ◽  
Ofer N. Gofrit ◽  
Thomas Akkad ◽  
...  

2006 ◽  
Vol 175 (4S) ◽  
pp. 268-269 ◽  
Author(s):  
Jessie L. Au ◽  
Robert A. Badalament ◽  
M. Guillaume Wientjes ◽  
Donn C. Young ◽  
Tong Shen ◽  
...  

2008 ◽  
Vol 225 (S 04) ◽  
Author(s):  
E Karioris ◽  
C Wirbelauer ◽  
H Häberle ◽  
DT Pham
Keyword(s):  

Pneumologie ◽  
2009 ◽  
Vol 63 (S 01) ◽  
Author(s):  
PC Bauer ◽  
U Sommerwerck ◽  
J Hagmeyer ◽  
F Bonella ◽  
U Costabel
Keyword(s):  

2011 ◽  
Vol 228 (S 02) ◽  
Author(s):  
AM Hoang ◽  
A Berthold ◽  
A Just ◽  
DT Pham ◽  
C Wirbelauer
Keyword(s):  

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