The effects of short- and long-term exposure of chick embryos to neutral red on the frequency of sister-chromatid exchange

1980 ◽  
Vol 70 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Judith Byrnes ◽  
Stephen E. Bloom
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Neutral Red ◽  
Chick Embryos ◽  
Short And Long Term

Neanthes arenaceodentata (Polychaeta: Annelida), a Proposed Cytogenetic Model for Marine Genetic Toxicology

1980 ◽  
Vol 37 (8) ◽  
pp. 1225-1228 ◽  
Author(s):  
Gerald G. Pesch ◽  
Carol E. Pesch
Keyword(s):  
Mitomycin C ◽  
Dose Response ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Marine Organisms ◽  
Marine Environments ◽  
Genetic Toxicology ◽  
Marine Polychaete

Genetic toxicants are present in polluted marine environments and may represent a long-term threat to populations of marine organisms. This paper presents details of an in vivo application of sister chromatid exchange (SCE) analysis to a marine polychaete worm Neanthes arenaceodentata. This species exhibits a dose response to mitomycin C (MMC) at concentrations comparable to those eliciting responses in in vivo mammalian systems. A dose of 5 × 10−7 mol/L MMC increased the rate of SCE from a baseline frequency of 0.14/chromosome to 0.5/chromosome. The chromosomes of N. arenaceodentata may provide a useful model for identifying and studying the effects of genetic toxicants in marine environments.Key words: sister chromatid exchange, chromosome, marine worm, polychaete

scholarly journals Association of Polymorphisms of Phase I Metabolizing Genes with Sister Chromatid Exchanges in Occupational Workers Exposed to Toluene Used in Paint Thinners

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Kanu Priya ◽  
Anita Yadav ◽  
Neeraj Kumar ◽  
Sachin Gulati ◽  
Neeraj Aggarwal ◽  
...  
Keyword(s):  
Phase I ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Sister Chromatid Exchanges ◽  
Confounding Factors ◽  
Genetic Damage ◽  
Blood Samples ◽  
Genotoxic Risk ◽  
Chromatid Exchanges

This study investigated genetic damage in paint workers mainly exposed to toluene as it is a major solvent used in paint thinners. Sister chromatid exchange (SCE) assay was used as biomarker of genotoxicity. Blood samples were collected from 30 paint workers and 30 control subjects matched with respect to age and other confounding factors except for exposure to toluene. SCE frequency was found to be significantly higher in paint workers (4.81±0.92) as compared to control individuals (1.73±0.54) (p<0.05). We also investigated influence of polymorphisms of CYP2E1 and CYP1A1m2 genes on SCE frequency. Our results showed that there was significant increase in frequencies of SCE among the mutant genotypes of CYP2E1 and CYP1A1m2 as compared to wild genotypes. Our study indicated that long term exposure of toluene can increase genotoxic risk in paint workers.

Variation in the human lymphocyte sister-chromatid exchange frequency: Results of a long-term longitudinal study

1988 ◽  
Vol 204 (3) ◽  
pp. 435-444 ◽  
Author(s):  
James D. Tucker ◽  
Linda K. Ashworth ◽  
George R. Johnston ◽  
Nancy A. Allen ◽  
Anthony V. Carrano
Keyword(s):  
Longitudinal Study ◽  
Human Lymphocyte ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Exchange Frequency ◽  
Sister Chromatid Exchange Frequency

Sister-chromatid exchange analysis on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever

2001 ◽  
Vol 68 (2) ◽  
pp. 121-122 ◽  
Author(s):  
RuŞen Dündaröz ◽  
Tahir Ozisik ◽  
Volkan Baltaci ◽  
Kasim Karapinar ◽  
Halil Ibrahim Aydin ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Secondary Prophylaxis ◽  
Benzathine Penicillin
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