Copulatory behavior in male rats with lesions in the bed nucleus of the stria terminalis

1976 ◽  
Vol 17 (5) ◽  
pp. 803-806 ◽  
Author(s):  
Donna E. Emery ◽  
Benjamin D. Sachs
Keyword(s):  
Copulatory Behavior ◽  
Male Rats ◽  
Stria Terminalis ◽  
Bed Nucleus

scholarly journals Role of CRF receptor 1 antagonism in the bed nucleus of the stria terminalis of male rats after intermittent social defeat stress

2019 ◽  
Author(s):  
Mailton Vasconcelos ◽  
Dirson J. Stein ◽  
Matheus Gallas-Lopes ◽  
Luane Landau ◽  
Luiza Behrens ◽  
...  
Keyword(s):  
Social Behavior ◽  
Social Stress ◽  
Social Behaviors ◽  
Social Defeat ◽  
Corticotropin Releasing Factor ◽  
Male Rats ◽  
Stria Terminalis ◽  
Social Avoidance ◽  
Bed Nucleus ◽  
Sweet Solution

AbstractWe recently demonstrated that the experience of brief episodes of social defeat caused impairments in social behaviors. Moreover, we provided evidence that the antagonism of corticotropin-releasing factor binding protein (CRFBP) in the bed nucleus of the stria terminalis (BNST) restored social approach in stressed animals. This study aimed to test the relation between corticotropin-releasing factor receptor type 1 (CRFR1) located in the BNST and the establishment of social stress-disrupted behaviors in rats submitted to social defeat in the resident-intruder paradigm. Animals were tested for sweet solution preference, subjected to the elevated-plus maze (EPM), and to the social interaction three-chamber test. Social behavior was tested after BNST drug infusions. The drug used in this study was a CRF receptor 1 antagonist, CP376395 (CP), administered in two doses: 50 ng/0.20 μL/side, and 500 ng/0.20 μL/side. Saline solution was used as vehicle and administered 0.20 μL/side. Socially stressed animals (n = 11) did not differ compared to control animals (n = 11) in the EPM. Stressed animals displayed impaired social behavior, represented by a decrease in time spent in the interaction zone. The lower dose (CP 50 ng/0.20 μL/side) administered intra-BNST restored social behaviors in stressed animals. On the other hand, the higher dose of the CRFR1 antagonist (CP 500 ng/0.20 μL/side) induced social avoidance in rats without a history of agonistic confrontations. These findings implicate BNST CRFR1 signaling in the modulation of social behaviors in rats given the choice to explore an unfamiliar conspecific.

scholarly journals Oxytocin selectively excites interneurons and inhibits output neurons of the bed nucleus of the stria terminalis (BNST)

2020 ◽  
Author(s):  
Walter Francesconi ◽  
Fulvia Berton ◽  
Valentina Olivera-Pasilio ◽  
Joanna Dabrowska
Keyword(s):  
Male Rats ◽  
Membrane Properties ◽  
Projection Neurons ◽  
Type I ◽  
Stria Terminalis ◽  
Type Ii ◽  
Spontaneous Firing ◽  
Bed Nucleus ◽  
Type Iii ◽  
Output Neurons

AbstractThe dorsolateral bed nucleus of the stria terminalis (BNSTDL) has high expression of oxytocin receptors, but their role in the modulation of BNSTDL activity remains elusive. BNSTDL contains GABA-ergic neurons classified based on intrinsic membrane properties into three types. Using in vitro patch-clamp and cell-attached recordings in male rats, we demonstrate that oxytocin excites and increases spontaneous firing of Type I, putative BNSTDL interneurons. As a consequence, oxytocin increases the frequency of spontaneous inhibitory post-synaptic currents (sIPSCs) (tetrodotoxin-sensitive) and reduces spontaneous firing of Type II neurons. In contrast, in Type III neurons, oxytocin reduces the amplitude of both sIPSCs and evoked IPSCs, suggesting a direct postsynaptic inhibitory effect. As Type II and Type III are the BNSTDL projection neurons, we present a model of fine-tuned modulation by oxytocin, which selectively excites Type I BNSTDL interneurons and inhibits Type II and Type III output neurons, via an indirect and direct mechanism, respectively.

scholarly journals Recovery of stress-impaired social behavior by an antagonist of the CRF binding protein, CRF6−33, in the bed nucleus of the stria terminalis of male rats

2019 ◽  
Vol 357-358 ◽  
pp. 104-110 ◽  
Author(s):  
Mailton Vasconcelos ◽  
Dirson J. Stein ◽  
Lucas Albrechet-Souza ◽  
Klaus A. Miczek ◽  
Rosa Maria M. de Almeida
Keyword(s):  
Social Behavior ◽  
Binding Protein ◽  
Male Rats ◽  
Stria Terminalis ◽  
Bed Nucleus
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