Selective determination of thiamine (vitamin B1) in pharmaceutical preparations by direct potentiometric argentometric titration with use of the silver—silver sulphide ion-selective electrode

A simple, fast, selective of a new flow injection analysis method coupled with potentiometric detection was used to determine vitamin B1 in pharmaceutical formulations via the prepared new selective membranes. Two electrodes were constructed for the determination of vitamin B1 based on the ion-pair vitamin B1-phosphotungestic acid (B1-PTA) in a poly (vinyl chloride) supported with a plasticized di-butyl phthalate (DBPH) and di-butyl phosphate (DBP). Applications of these ion selective electrodes for the determination of vitamin B1 in the pharmaceutical preparations for batch and flow injection systems were described. The ion selective membrane exhibited a near-Nernstian slope values 56.88 and 58.53 mV / decade, with the linear dynamic range of vitamin B1 was 5 x 10-5- 1 x 10-2 and 1 x 10-4-1 x 10-2 mol.L-1, in batch and FIA, respectively. The limit of detection was 3.5 x 10-5 and 9.5 x 10-5 mol.L-1, with the percentage linearity 98.85 and 95.22 in batch and FIA, respectively. The suggested ion selective electrode has been utilized perfection in the determination of vitamin B1 in pharmaceutical formulations using batch and flow injection system, respectively.

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Determination of Vitamin Bi in Pharmaceutical Preparations Using a Lead Ion Selective Electrode and Atomic Absorption Spectroscopy

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/62.2.315 ◽

1979 ◽

Vol 62 (2) ◽

pp. 315-319

Author(s):

Saad S M Hassan ◽

Mohamed T Zaki ◽

Mohamed H Eldesouki

Keyword(s):

Standard Deviation ◽

Atomic Absorption ◽

Absorption Spectroscopy ◽

Atomic Absorption Spectroscopy ◽

Pharmaceutical Preparations ◽

Ion Selective Electrode ◽

Lead Ion ◽

Fluorometric Method ◽

Selective Electrode

Abstract Simple, rapid, and accurate methods have been developed for determining vitamin Bx in pharmaceutical preparations without prior separation of the vitamin. The methods are based on the desulfurization reaction with potassium plumbite and measurement of the unreacted lead (II) ions at 217 nm using atomic absorption spectroscopy (AAS), or by titration with EDTA at pH 4.5 with the lead ion selective electrode and Gran's plot. The results compare favorably with those obtained using the USP fluorometric method. Recoveries of pure vitamin Bx averaged 99.1%, with a standard deviation of 0.8%, and 99.0%, with a standard deviation of 0.7%, for the AAS and ion selective electrode procedures, respectively.

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Determination of sulphide using flow injection analysis with a coated tubular solid-state silver sulphide ion-selective electrode

The Analyst ◽

10.1039/an9881300885 ◽

1988 ◽

Vol 113 (6) ◽

pp. 885 ◽

Cited By ~ 18

Author(s):

Jacobus F. van Staden

Keyword(s):

Solid State ◽

Flow Injection ◽

Flow Injection Analysis ◽

Ion Selective Electrode ◽

Selective Electrode ◽

Silver Sulphide

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Characterization and Applications of Silver Sulphide Based Membrane Electrodes

Scientific World ◽

10.3126/sw.v7i7.3818 ◽

1970 ◽

Vol 7 (7) ◽

pp. 19-23 ◽

Cited By ~ 5

Author(s):

A Rajbhandari ◽

AP Yadav ◽

K Manandhar ◽

RR Pradhananga

Keyword(s):

Silver Chloride ◽

Silver Halide ◽

Ion Selective Electrode ◽

Ion Selective Electrodes ◽

Powder Materials ◽

Membrane Electrodes ◽

Selective Electrode ◽

Sulphide Ions ◽

Silver Sulphide

The polycrystalline materials obtained by co-precipitation of silver sulphide and appropriate silver halide are used to prepare silver sulphide based membrane electrodes selective to the silver, chloride, bromide, iodide, and sulphide ions. The powder materials are characterized by x-ray diffraction, SEM equipped with EDAX. These membrane electrodes are found to give Nernstian response with the appropriate ions in the concentration range from 1x10-1 to 1x10-5 M. The performance of these home made electrodes is at par with the commercial electrodes. The electrodes have been successfully used for the quantitative determination of chloride, bromide iodide, silver, and sulphide ions and also for the determination of thiamine in pharmaceutical preparations. For developing countries like Nepal, who can not afford to procure high cost commercial ion selective electrodes, these home made ion selective electrodes are especially appealing since the electrode can be fabricated with ease in low cost and the electrode is well behaved and sufficiently accurate for the analysis with ion selective electrodes. Key words: Ion selective electrode; Home made ion selective electrode; Silver sulphide; Thiamine; Vitamin B1. DOI: 10.3126/sw.v7i7.3818 Scientific World Vol.7(7) 2009 pp.19-23

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Fabrication and Applications of Silver Sulphide Based Ion Sensors

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.117.7 ◽

2010 ◽

Vol 117 ◽

pp. 7-14

Author(s):

Raja Ram Pradhananga ◽

A. Nyachhyon ◽

A.P. Yadav ◽

Lok Kumar Shrestha ◽

S. Tandukar

Keyword(s):

Cigarette Smoke ◽

Hydrogen Sulphide ◽

Electrochemical Techniques ◽

Ion Selective Electrode ◽

Ion Concentration ◽

Ion Selective Electrodes ◽

Selective Electrode ◽

Ion Sensors ◽

Silver Sulphide

An electrochemical sensor based on the silver sulphide precipitate was fabricated in the laboratory and characterized by x-ray diffraction, SEM equipped with EDAX, and electrochemical techniques. Ion selective electrode (ISE) was found to be sensitive enough to sense the sulphide ion concentration from 10-1 to 10-5 M in alkaline medium. The change in electrode potential per decade change in sulphide ion concentration was found to be 31.5 mV at laboratory temperature indicating adherence of the ion selective electrode to Nernst’s equation. The sensor have been successfully used for the quantitative determination of thiamine in pharmaceutical preparations, hydrogen sulphide in cigarette smoke and determination of solubility products of sparingly soluble silver salts. A trace amount of hydrogen sulphide, a toxic gas, is present in the cigarette smoke. The quantitative estimation of hydrogen sulphide in cigarette smoke is a challenging task to analytical chemist. Hydrogen sulphide in cigarette smoke had been determined by absorbing the cigarette smoke in 0.1 M sodium hydroxide and the resulting solution was analyzed using silver sulphide based ion sensor by standard addition technique using modified Gran plot. The average amounts of hydrogen sulphide produced by a stick of cigarette in 8 different brands of Nepalese cigarette ware found to range from 0.0332 mg to 0.0766 mg. The sensitivity and reliability of these home made ion sensors were excellent and in par with commercial electrodes. For developing countries like Nepal, who can not afford to procure high cost commercial ion selective electrodes, these home made ion sensors are especially appealing since the sensor can be fabricated with ease from the materials that are readily available in the chemistry laboratory and the sensor is quite sensitive and gives reproducible results which are sufficiently accurate for the analysis with ion selective electrodes.

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