Effects of topical retinoids on photoaged skin as measured by optical profilometry

1990 ◽  
pp. 360-371 ◽  
Author(s):  
Gary L. Grove ◽  
Mary Jo Grove
Keyword(s):  
Optical Profilometry ◽  
Photoaged Skin ◽  
Topical Retinoids

scholarly journals Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

2021 ◽  
Author(s):  
Jan Wadstein ◽  
Israel Sánchez Alvarez ◽  
Erling Thom ◽  
Lidia Bernal López
Keyword(s):  
Replacement Therapy ◽  
Skin Irritation ◽  
Dual Therapy ◽  
Skin Thickness ◽  
Synergistic Activity ◽  
Therapeutic Modalities ◽  
Photoaged Skin ◽  
Topical Retinoids ◽  
Wide Range ◽  
Aged Skin

Skin ageing is a progressive but modifiable, multi-factorial disorder that involves all skin tissues. Pertaining to its wide range of physiological and psychosocial complications, skin ageing requires rigorous clinical attention. Topical retinoids and per-oral proteoglycans are promising, non-invasive, therapeutic modalities. To overcome the low bioavailability of conventional free retinoids, Nourella® cream with Retilex-A® (Pharma Medico, Aarhus, Denmark) was developed using a proprietary nano-encapsulation technology. The nano-encapsulation is a sophisticated ‘permeation/penetration enhancer’ that optimises topical drug delivery by increasing surface availability and net absorption ratio. Treatment adherence is also improved by minimising skin irritation. Interventional evidence supports the higher efficacy of Retilex-A® in improving skin thickness and elasticity compared with conventional free forms. It is also reported that the rejuvenating efficacy of Retilex-A® and tretinoin are comparable. Another skin anti-ageing approach is proteoglycan replacement therapy (PRT) with Vercilex®. Vercilex® in Nourella® tablet has the potential to ameliorate proteoglycan dysmetabolism in the aged skin by activating skin cells and improving collagen/elastin turnover. Replicated clinical trials evidenced that PRT can significantly enhance the density, elasticity and thickness of both intrinsically aged and photoaged skin. Evidently, Vercilex® and Retilex-A® share a range of bioactivities, which underlies their synergistic activity observed in a clinical trial. Dual therapy with Nourella® tablets and cream produced higher effect sizes on skin characteristics than monotherapy with each of the two treatments. In conclusion, Nourella® cream and tablets are safe and effective treatments for skin ageing; however, combining the two in a ‘dual skin rejuvenation system’ significantly improves treatment outcomes.

Maintenance acne therapy: prophylactic efficacy of fixed combination of adapalene and benzoyl peroxide

2020 ◽  
pp. 57-62
Author(s):  
L. S. Kruglova ◽  
N. V. Gryazeva
Keyword(s):  
Maintenance Therapy ◽  
Fixed Combination ◽  
Psychological Impact ◽  
Supportive Therapy ◽  
Prophylactic Efficacy ◽  
Severe Acne ◽  
Topical Retinoids ◽  
Acne Therapy ◽  
Group 2 ◽  
Treatment Observation

Acne is a chronic disease and even reliable therapies do not completely ensure absence of relapses. Acne relapses have a negative psychological impact on patients, as they feel unable to control the disease and achieve complete and long-lasting recovery. Supportive therapy is necessary to prolong the remission of acne achieved with initial successful treatment and to minimize the risk of relapse. According to the literature sources, the most justified as a maintenance therapy is the use of topical retinoids, which have been shown to be effective in the prevention of exacerbations of acne. In the present study 54 patients were involved who after the active therapy used a fixed combination of adapalene 0.1% / BPO 2.5% as maintenance treatment. Only 1 patient (2.9%) with moderate acne and 2 patients (5.8%) with severe acne had a relapse within 6 months of maintenance therapy. The absence of adverse events during the course of treatment was recorded, as well as high adherence of patients to the treatment. During the period of post-treatment observation (6 months after maintenance therapy), among the patients without exacerbations during maintenance therapy, a relapse occurred in 2 (7.1%) patients of group 1 (n = 28) and 2 (8.7%) patients of group 2 (n = 23). The obtained data indicates that maintenance therapy with Effezel® gel can extend the achieved effectiveness of the treatment and prevent the development of relapses.

Topical retinoids

Farmacist ro ◽  
2020 ◽  
Vol 2 (193) ◽  
pp. 20
Author(s):  
Georgiana Niţulescu ◽  
George Mihai Niţulescu
Keyword(s):  
Topical Retinoids

Calculating Sputter Rate Angular Dependence Using Optical Profilometry (Preprint)

2007 ◽  
Author(s):  
Alexander C. Barrie ◽  
Bryan S. Taylor ◽  
Jared M. Ekholm ◽  
Jr Hargus ◽  
William A.
Keyword(s):  
Angular Dependence ◽  
Optical Profilometry

scholarly journals HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts

2020 ◽  
Vol 295 (8) ◽  
pp. 2483-2494
Author(s):  
Hiroyuki Yoshida ◽  
Mika Aoki ◽  
Aya Komiya ◽  
Yoko Endo ◽  
Keigo Kawabata ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Fold Increase ◽  
Histamine Receptor ◽  
Skin Fibroblasts ◽  
Dependent Manner ◽  
Skin Damage ◽  
Photoaged Skin ◽  
Molecular Sizes ◽  
Ha Synthase ◽  
Hyaluronan Binding

The immune-regulatory compound histamine is involved in the metabolism of the essential skin component hyaluronan (HA). We previously reported that histamine up-regulates the expression of HYBID (hyaluronan-binding protein involved in hyaluronan depolymerization, also called CEMIP or KIAA1199), which plays a key role in HA degradation. However, no information is available about histamine's effects on HA synthase (HAS) expression, the molecular sizes of HA species produced, and histamine receptors and their signaling pathways in skin fibroblasts. Moreover, histamine's effects on photoaged skin remain elusive. Here, we show that histamine increases HA degradation by up-regulating HYBID and down-regulating HAS2 in human skin fibroblasts in a dose- and time-dependent manner and thereby decreases the total amounts and sizes of newly produced HA. Histamine H1 blocker abrogated the histamine effects on HYBID up-regulation, HAS2 suppression, and HA degradation. Histamine H1 agonist exhibited effects on HA levels, composition, and breakdown similar to those of histamine. Of note, blockade of protein kinase Cδ or PI3K–Akt signaling abolished histamine-mediated HYBID stimulation and HAS2 suppression, respectively. Immunohistochemical experiments revealed a significant ∼2-fold increase in tryptase-positive mast cells in photoaged skin, where HYBID and HAS2 expression levels were increased and decreased, respectively, compared with photoprotected skin. These results indicate that histamine controls HA metabolism by up-regulating HYBID and down-regulating HAS2 via distinct signaling pathways downstream of histamine receptor H1. They further suggest that histamine may contribute to photoaged skin damage by skewing HA metabolism toward degradation.

scholarly journals Antifouling and Flux Enhancement of Reverse Osmosis Membrane by Grafting Poly (3-Sulfopropyl Methacrylate) Brushes

Membranes ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 213
Author(s):  
Reema Mushtaq ◽  
Muhammad Asad Abbas ◽  
Shehla Mushtaq ◽  
Nasir M. Ahmad ◽  
Niaz Ali Khan ◽  
...  
Keyword(s):  
Contact Angle ◽  
Reverse Osmosis ◽  
Polymer Brushes ◽  
Surface Composition ◽  
Reverse Osmosis Membrane ◽  
Optical Profilometry ◽  
Thin Film Composite ◽  
Membrane Sample ◽  
Contact Angle Analysis ◽  
And Staphylococcus Aureus

A commercial thin film composite (TFC) polyamide (PA) reverse osmosis membrane was grafted with 3-sulfopropyl methacrylate potassium (SPMK) to produce PA-g-SPMK by atom transfer radical polymerization (ATRP). The grafting of PA was done at varied concentrations of SPMK, and its effect on the surface composition and morphology was studied by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), optical profilometry, and contact angle analysis. The grafting of hydrophilic ionically charged PSPMK polymer brushes having acrylate and sulfonate groups resulted in enhanced hydrophilicity rendering a reduction of contact angle from 58° of pristine membrane sample labeled as MH0 to 10° for a modified membrane sample labeled as MH3. Due to the increased hydrophilicity, the flux rate rises from 57.1 L m−2 h−1 to 71.2 L m−2 h−1, and 99% resistance against microbial adhesion (Escherichia coli and Staphylococcus aureus) was obtained for MH3 after modification

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