SPECT imaging of Moyamoya disease using 99mTc-HM-PAO comparison with computed tomography findings

Objective: There are no previous studies using single photon emission computed tomography (SPECT) scans in somatization disorder (SD) patients. The aim of this paper is to assess SPECT imaging abnormalities in SD patients and study any relation to laterality. Method: Eleven SD patients from the Somatization Disorder Unit of Miguel Servet University Hospital, Zaragoza, Spain, not fulfilling criteria for any other psychiatric disorder and showing normal computed tomography (CT) and magnetic resonance imaging (MRI) images were studied with SPECT. Patients with DSM-IV axis I comorbidity were ruled out because it has been demonstrated that SPECT scans can show abnormalities in patients with depression and anxiety disorders. The technique used for SPECT was 99mTc-D,1,hexamethylpropyleneamide- oxime (99mTc-HMPAO) in four patients and 99mTc-bicisate in the other seven. The SPECT scans were evaluated without knowledge of clinical data and entirely by visual inspection. Results: Seven out of 11 (63.6%) SD patients showed hypoperfusion in SPECT imaging. In four cases there was hypoperfusion in the non-dominant hemisphere and the predominance of pain symptoms took place in the contralateral hemibody. In the other three patients hypoperfusion was bilateral. The anatomical regions affected were cerebellum (four cases), frontal and prefrontal areas (three cases), temporoparietal areas (two cases) and the complete hemisphere (one case). Conclusions: A proportion of SD patients may present hypoperfusion in SPECT images, uni- or bilaterally, in different brain areas. Possible aetiological explanations for this finding are discussed. Controlled studies are necessary to confirm or refute this hypothesis.

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Comparative Prospective Detection of Recurrences of Carcinomas with SPECT Imaging Using Radiolabeled Monoclonal Antibodies, Ultrasonography and Computed Tomography

Radiolabeled Monoclonal Antibodies for Imaging and Therapy ◽

10.1007/978-1-4684-5538-0_37 ◽

1988 ◽

pp. 557-569

Author(s):

Jean-Francois Chatal

Keyword(s):

Computed Tomography ◽

Monoclonal Antibodies ◽

Spect Imaging

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A case report of moyamoya disease in children treated with encephalo-duro-myo-arterio-pericranial synangiosis

Medical Journal of Indonesia ◽

10.13181/mji.cr.204452 ◽

2021 ◽

Author(s):

Julius July

Keyword(s):

Computed Tomography ◽

Case Report ◽

Magnetic Resonance Angiography ◽

Moyamoya Disease ◽

Internal Carotid ◽

Language Function ◽

Vascular Networks ◽

Ischemic Event ◽

Special Challenge ◽

Ischemic Attack

Moyamoya disease that manifests during childhood may pose a special challenge for surgeons. We report a case of a 10-year-old girl who suffered from moyamoya disease and was successfully treated with encephalo-duro-myo-arterio-pericranial synangiosis (EDMAPS). She presented with a recurrent transient ischemic attack that worsened for 1 year. She was aphasic globally (sensory and motor) and had slightly weak right extremities. Her magnetic resonance angiography and computed tomography angiography showed the typical features of moyamoya disease with bilateral stenosis at the terminal internal carotid artery, bilaterally abnormal vascular networks, and a left ischemic event involving the temporoparietal region. She was recovered well after underwent bilateral EDMAPS, fully regained her language function after 3 months, and gathered her strength back. Therefore, EDMAPS could be a good, safe, and effective treatment for moyamoya disease in children.

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Unusual presentation of moyamoya disease with popliteal involvement: case report and review of the literature

Jornal Vascular Brasileiro ◽

10.1590/1677-5449.200216 ◽

2021 ◽

Vol 20 ◽

Author(s):

Mustafa Etli ◽

Oguz Karahan

Keyword(s):

Computed Tomography ◽

Case Report ◽

Moyamoya Disease ◽

Doppler Sonography ◽

Anticoagulant Treatment ◽

Review Of The Literature ◽

Peripheral Vascular ◽

Bilateral Carotid Occlusion ◽

Bilateral Carotid ◽

Cerebrovascular System

Abstract Moyamoya disease is a rare disorder that involves the cerebrovascular system. Usually, it leads to occlusion of the arteries of the cerebral system and causes cerebral circulatory complaints. A 48-year-old female patient was admitted to our clinic with intermittent claudication in both legs. Biphasic and monophasic waveform patterns were detected bilaterally in distal (trifurcation arteries) lower extremities with Doppler sonography. The patient therefore underwent systemic vascular examination. Computed tomography angiography revealed bilateral carotid occlusion at the level of supraclinoid segments, and opacifications were detected at the distal segments of the bilateral anterior cerebellar and middle cerebellar arteries. The patient was diagnosed with moyamoya disease, and anticoagulant treatment was started. In conclusion, most previous reports have presented the cerebrovascular involvement of moyamoya disease. However, this disease can involve different peripheral vascular systems and careful and systemic vascular examination is necessary for an exact diagnosis.

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Surgical Outcome for Moyamoya Disease: Clinical and Perfusion Computed Tomography Correlation

World Neurosurgery ◽

10.1016/j.wneu.2016.10.117 ◽

2017 ◽

Vol 98 ◽

pp. 81-88 ◽

Cited By ~ 7

Author(s):

Alvin Ho-Kwan Cheung ◽

Angus Ka-Cheong Lam ◽

Wai-Shing Wilson Ho ◽

Chun-Pong Tsang ◽

Anderson Chun-On Tsang ◽

...

Keyword(s):

Computed Tomography ◽

Moyamoya Disease ◽

Surgical Outcome ◽

Perfusion Computed Tomography

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Use of asymmetric fan-beam transmission computed tomography for attenuation correction of cardiac SPECT imaging

Medical Physics ◽

10.1118/1.598986 ◽

2000 ◽

Vol 27 (5) ◽

pp. 1208-1208 ◽

Cited By ~ 1

Author(s):

Edward F. Hollinger

Keyword(s):

Computed Tomography ◽

Attenuation Correction ◽

Spect Imaging ◽

Cardiac Spect ◽

Transmission Computed Tomography ◽

Beam Transmission

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Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice

AJP Renal Physiology ◽

10.1152/ajprenal.00413.2009 ◽

2010 ◽

Vol 298 (2) ◽

pp. F454-F460 ◽

Cited By ~ 13

Author(s):

François Jouret ◽

Stéphan Walrand ◽

Kleber S. Parreira ◽

Pierre J. Courtoy ◽

Stanislas Pauwels ◽

...

Keyword(s):

Computed Tomography ◽

Proximal Tubule ◽

Knockout Mice ◽

Single Photon ◽

Photon Emission ◽

Spect Imaging ◽

Emission Computed Tomography ◽

Single Photon Emission ◽

Single Photon Emission Computed ◽

Photon Emission Computed Tomography

Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included 99mTC- dimercaptosuccinic acid (99mTc-DMSA), which is used for cortex imaging; 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), used for dynamic renography; and 123I-β2-microglobulin, which monitors receptor-mediated endocytosis. 99mTc-DMSA SPECT imaging was shown to delineate the functional renal cortex with a ∼1-mm spatial resolution and accumulated in the cortex reaching a plateau 5 h after injection. The cortical uptake of 99mTc-DMSA was abolished in Clcn5 knockout mice, a model of proximal tubule dysfunction. Dynamic renography with 99mTc-MAG3 in conscious mice demonstrated rapid extraction from blood, renal accumulation, and subsequent tubular secretion. Anesthesia induced a significant delay in the 99mTc-MAG3 clearance. The tubular reabsorption of 123I-β2-microglobulin was strongly impaired in the Clcn5 knockout mice, with defective tubular processing and loss of the native tracer in urine, reflecting proximal tubule dysfunction. Longitudinal studies in a model of cisplatin-induced acute tubular injury revealed a correlation between tubular recovery and 123I-β2-microglobulin uptake. These data show that SPECT imaging with well-validated radiotracers allows in vivo investigations of specific proximal tubule functions in conscious mice.

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