Comparative Prospective Detection of Recurrences of Carcinomas with SPECT Imaging Using Radiolabeled Monoclonal Antibodies, Ultrasonography and Computed Tomography

Objective: There are no previous studies using single photon emission computed tomography (SPECT) scans in somatization disorder (SD) patients. The aim of this paper is to assess SPECT imaging abnormalities in SD patients and study any relation to laterality. Method: Eleven SD patients from the Somatization Disorder Unit of Miguel Servet University Hospital, Zaragoza, Spain, not fulfilling criteria for any other psychiatric disorder and showing normal computed tomography (CT) and magnetic resonance imaging (MRI) images were studied with SPECT. Patients with DSM-IV axis I comorbidity were ruled out because it has been demonstrated that SPECT scans can show abnormalities in patients with depression and anxiety disorders. The technique used for SPECT was 99mTc-D,1,hexamethylpropyleneamide- oxime (99mTc-HMPAO) in four patients and 99mTc-bicisate in the other seven. The SPECT scans were evaluated without knowledge of clinical data and entirely by visual inspection. Results: Seven out of 11 (63.6%) SD patients showed hypoperfusion in SPECT imaging. In four cases there was hypoperfusion in the non-dominant hemisphere and the predominance of pain symptoms took place in the contralateral hemibody. In the other three patients hypoperfusion was bilateral. The anatomical regions affected were cerebellum (four cases), frontal and prefrontal areas (three cases), temporoparietal areas (two cases) and the complete hemisphere (one case). Conclusions: A proportion of SD patients may present hypoperfusion in SPECT images, uni- or bilaterally, in different brain areas. Possible aetiological explanations for this finding are discussed. Controlled studies are necessary to confirm or refute this hypothesis.

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Abstract 008: Novel Pathological Diagnosis Between Aldosterone Producing Adenoma And Idiopathic Hyperaldosteronism

Hypertension ◽

10.1161/hyp.64.suppl_1.008 ◽

2014 ◽

Vol 64 (suppl_1) ◽

Author(s):

Fumitoshi Satoh ◽

Yoshikiyo Ono ◽

Ryo Morimoto ◽

Masataka Kudo ◽

Yoshitsugu Iwakura ◽

...

Keyword(s):

Computed Tomography ◽

Monoclonal Antibodies ◽

Tumor Size ◽

Zona Glomerulosa ◽

Maximum Diameter ◽

Steroidogenic Enzymes ◽

The Status ◽

Aldosterone Producing Adenoma ◽

Idiopathic Hyperaldosteronism ◽

Tumor Area

The expressions of steroidogenic enzymes to produce aldosterone like CYP11B1, CYP11B2, 3BHSD1 and 3BHSD2 remain to be clarified to confirm pathological subclassification between aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA). Furthermore, we examined the correlation between APA tumor size and the status of intratumoral steroidogenic enzymes involved in aldosterone biosynthesis using immunohistochemistry. Surgically proven forty APA patients and ten IHA patients were retrospectively studied. Multi-detector computed tomography, AVS, and laparoscopic adrenalectomy were performed in all of the patients studied. The tumor area of APA at the maximum diameter of the sections was precisely measured by ImageJ software. The status of steroidogenic enzymes was immunohistochemically analyzed using monoclonal antibodies for CYP11B1, CYP11B2, 3BHSD1 and 3BHSD2, and the findings were evaluated according to the H-score system, based on both the number of immunopositive cells and relative immunointensity. Adrenal masses were not detected by computed tomography in 20 APA patients.In all of 10 IHA patients, hyperplastic zona glomerulosa was accompanied by an expression of HSD3B1. In contrast, tumor cells in all 40 APA patients were not immunopositive to HSD3B1, but strongly and dominanty expressed HSD3B2. Perhaps, due to compensatory responses to excess aldosterone, APA had an adjacent zona glomerulosa whose immunoreactivities to HSD3B1 and HSD3B2 were profoundly reduced in all 40 APA patients. Maximum tumor area obtained in the specimens was significantly correlated with preoperative plasma aldosterone concentration, urinary aldosterone excretion, the H-score of CYP11B1, and was inversely correlated with the H-score of CYP11B2. These results demonstrated that small adenomas could produce sufficient aldosterone to cause clinically overt primary aldosteronism because of the significantly higher CYP11B2 expression per tumor area. Monoclonal antibodies against HSD3B1 and HSD3B2 could be useful for immunohistochemical differentiation between APA and IHA. In addition, the relatively higher CYP11B2 expression per area in smaller APA could clinically cause PA despite their CT-undetectable tumor size.

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Use of asymmetric fan-beam transmission computed tomography for attenuation correction of cardiac SPECT imaging

Medical Physics ◽

10.1118/1.598986 ◽

2000 ◽

Vol 27 (5) ◽

pp. 1208-1208 ◽

Cited By ~ 1

Author(s):

Edward F. Hollinger

Keyword(s):

Computed Tomography ◽

Attenuation Correction ◽

Spect Imaging ◽

Cardiac Spect ◽

Transmission Computed Tomography ◽

Beam Transmission

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Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice

AJP Renal Physiology ◽

10.1152/ajprenal.00413.2009 ◽

2010 ◽

Vol 298 (2) ◽

pp. F454-F460 ◽

Cited By ~ 13

Author(s):

François Jouret ◽

Stéphan Walrand ◽

Kleber S. Parreira ◽

Pierre J. Courtoy ◽

Stanislas Pauwels ◽

...

Keyword(s):

Computed Tomography ◽

Proximal Tubule ◽

Knockout Mice ◽

Single Photon ◽

Photon Emission ◽

Spect Imaging ◽

Emission Computed Tomography ◽

Single Photon Emission ◽

Single Photon Emission Computed ◽

Photon Emission Computed Tomography

Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included 99mTC- dimercaptosuccinic acid (99mTc-DMSA), which is used for cortex imaging; 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), used for dynamic renography; and 123I-β2-microglobulin, which monitors receptor-mediated endocytosis. 99mTc-DMSA SPECT imaging was shown to delineate the functional renal cortex with a ∼1-mm spatial resolution and accumulated in the cortex reaching a plateau 5 h after injection. The cortical uptake of 99mTc-DMSA was abolished in Clcn5 knockout mice, a model of proximal tubule dysfunction. Dynamic renography with 99mTc-MAG3 in conscious mice demonstrated rapid extraction from blood, renal accumulation, and subsequent tubular secretion. Anesthesia induced a significant delay in the 99mTc-MAG3 clearance. The tubular reabsorption of 123I-β2-microglobulin was strongly impaired in the Clcn5 knockout mice, with defective tubular processing and loss of the native tracer in urine, reflecting proximal tubule dysfunction. Longitudinal studies in a model of cisplatin-induced acute tubular injury revealed a correlation between tubular recovery and 123I-β2-microglobulin uptake. These data show that SPECT imaging with well-validated radiotracers allows in vivo investigations of specific proximal tubule functions in conscious mice.

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Acute Infantile Bilateral Striatal Necrosis: Single-Photon Emission Computed Tomography (SPECT) Imaging and Review

Journal of Child Neurology ◽

10.1177/0883073807304194 ◽

2007 ◽

Vol 22 (10) ◽

pp. 1222-1226 ◽

Cited By ~ 4

Author(s):

Noam Zevit ◽

Adam Steinmetz ◽

Liora Kornreich ◽

Rachel Straussberg

Keyword(s):

Computed Tomography ◽

Single Photon ◽

Photon Emission ◽

Spect Imaging ◽

Emission Computed Tomography ◽

Single Photon Emission ◽

Emission Computed ◽

Single Photon Emission Computed ◽

Photon Emission Computed Tomography ◽

Striatal Necrosis

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Compton-camera-based SPECT for thyroid cancer imaging

Journal of X-Ray Science and Technology ◽

10.3233/xst-200769 ◽

2020 ◽

pp. 1-14

Author(s):

Hengyong Yu ◽

Ge Wang

Keyword(s):

Computed Tomography ◽

Thyroid Cancer ◽

Detection Efficiency ◽

Single Photon ◽

Photon Emission ◽

Resolution Enhancement ◽

Spect Imaging ◽

Emission Computed Tomography ◽

Compton Camera ◽

Study Results

Thyroid cancer is the most common type of endocrine-related cancer and the most common cancer in young women. Currently, single photon emission computed tomography (SPECT) and computed tomography (CT) are used with radioiodine scintigraphy to evaluate patients with thyroid cancer. The gamma camera for SPECT contains a mechanical collimator that greatly compromises dose efficiency and limits diagnostic sensitivity. Fortunately, the Compton camera is emerging as an ideal approach for mapping the distribution of radiopharmaceuticals inside the thyroid. In this preliminary study, based on the state-of-the-art readout chip Timepix3, we investigate the feasibility of using Compton camera for radiotracer SPECT imaging in thyroid cancer. A thyroid phantom is designed to mimic human neck, the mechanism of Compton camera-based event detection is simulated to generate realistic list-mode data, and a weighted back-projection method is developed to reconstruction the original distribution of the emission source. Study results show that the Compton camera can improve the detection efficiency for two or higher orders of magnitude comparing with the conventional gamma cameras. The thyroid gland regions can be reconstructed from the Compton camera measurements in terms of radiotracer distribution. This makes the Compton-camera-based SPECT imaging a promising modality for future clinical applications with significant benefits for dose reduction, scattering artifact reduction, temporal resolution enhancement, scan throughput increment, and others.

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