A new extra sequence at the amino terminal of a μ heavy chain disease protein (DAG)

1990 ◽  
Vol 27 (8) ◽  
pp. 771-776 ◽  
Author(s):  
C. Mihaesco ◽  
P. Ferrara ◽  
J.C. Guillemot ◽  
N. Congy ◽  
M.C. Gendron ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Amino Terminal ◽  
Disease Protein ◽  
Extra Sequence ◽  
Heavy Chain Disease

Gamma heavy chain disease studied by two-dimensional electrophoresis and immuno-blotting techniques.

1984 ◽  
Vol 30 (12) ◽  
pp. 2021-2025 ◽  
Author(s):  
P Blangarin ◽  
P Deviller ◽  
K Kindbeiter ◽  
J J Madjar
Keyword(s):  
Heavy Chain ◽  
Monoclonal Gammopathy ◽  
Serum Proteins ◽  
Polyacrylamide Gel Electrophoresis ◽  
Two Dimensional ◽  
Two Dimensional Electrophoresis ◽  
Disease Protein ◽  
Dimensional Mapping ◽  
Dimensional Electrophoresis ◽  
Heavy Chain Disease

Abstract We used two-dimensional polyacrylamide gel electrophoresis and immunoblotting techniques to study serum proteins from a patient with a monoclonal gammopathy. Two-dimensional electrophoresis was optimized for serum proteins with two main goals: (a) to allow the resolution of many serum proteins in both directions, with penetration of the maximum number of proteins in the first dimension; and (b) to obtain the best reproducibility from one experiment to another, within the limits of the current technique. These analyses, combined with immunoblotting, permitted us to characterize a gamma heavy chain disease protein of 34 000-Da molecular mass. Moreover, two-dimensional mapping of the patient's serum proteins allowed demonstration of the microheterogeneity of this monoclonal component.

N- and C-terminal amino acid sequences of a γ-heavy chain disease protein YOK

1976 ◽  
Vol 13 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Yoko Nabeshima ◽  
Tokuji Ikenaka ◽  
Terukatsu Arima
Keyword(s):  
Amino Acid ◽  
Heavy Chain ◽  
Amino Acid Sequences ◽  
Terminal Amino Acid ◽  
Disease Protein ◽  
Terminal Amino ◽  
Heavy Chain Disease

Complete variable region deletion in Aα heavy chain disease protein (roul). Correlation with light chain secretion

1993 ◽  
Vol 17 (6) ◽  
pp. 527-532 ◽  
Author(s):  
Michel Cogné ◽  
Pierre Aucouturier ◽  
André Brizard ◽  
Brigitte Dreyfus ◽  
Françoise Duarte ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Light Chain ◽  
Variable Region ◽  
Disease Protein ◽  
Heavy Chain Disease

scholarly journals An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein

Blood ◽  
1978 ◽  
Vol 51 (1) ◽  
pp. 85-96 ◽  
Author(s):  
JB Adlersberg ◽  
V Grann ◽  
D Zucker-Franklin ◽  
B Frangione ◽  
EC Franklin
Keyword(s):  
Heavy Chain ◽  
Unusual Case ◽  
Serum Proteins ◽  
Mutational Event ◽  
Myeloma Protein ◽  
Plasma Cell Neoplasm ◽  
Pathologic Features ◽  
Disease Protein ◽  
Probable Origin ◽  
Heavy Chain Disease

Abstract A unique case of gamma3 heavy chain disease with two related serum proteins is reported. One molecule appears to be an IgG3lambda myeloma protein. The second molecule is a dimer of a shortened gamma3 heavy chain that has an unblocked amino terminus and lacks the VH and CH1 domains. Its probable origin as a synthetic product is discussed. The clinical and pathologic features of this patient resemble those of other patients with gamma heavy chain disease more than those of patients with multiple myeloma. It seems likely that the heavy chain disease protein is the result of a mutational event in the malignant clone originally producing the myeloma protein.

scholarly journals A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein.

1986 ◽  
Vol 83 (8) ◽  
pp. 2689-2693 ◽  
Author(s):  
A. Bakhshi ◽  
P. Guglielmi ◽  
U. Siebenlist ◽  
J. V. Ravetch ◽  
J. P. Jensen ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Disease Protein ◽  
Dna Insertion ◽  
Aberrant Rna ◽  
Heavy Chain Disease
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