Age-related changes in binding to excitatory amino acid uptake site in temporal cortex of human brain

1992 ◽  
Vol 65 (2) ◽  
pp. 157-160 ◽  
Author(s):  
P. Slater ◽  
McConnell ◽  
S.W. D'Souza ◽  
A.J. Barson ◽  
M.D.C. Simpson ◽  
...  
Keyword(s):  
Amino Acid ◽  
Human Brain ◽  
Excitatory Amino Acid ◽  
Temporal Cortex ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Age Related ◽  
Age Related Changes

Age-related changes in binding to excitatory amino acid uptake sites in human cerebellum

1992 ◽  
Vol 579 (2) ◽  
pp. 219-226 ◽  
Author(s):  
P. Slater ◽  
S. McConnell ◽  
S.W. D'Souza ◽  
A.J. Barson
Keyword(s):  
Amino Acid ◽  
Excitatory Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Age Related ◽  
Human Cerebellum ◽  
Uptake Sites ◽  
Age Related Changes

scholarly journals Use of [11C]Aminocyclohexanecarboxylate for the Measurement of Amino Acid Uptake and Distribution Volume in Human Brain

1990 ◽  
Vol 10 (5) ◽  
pp. 727-739 ◽  
Author(s):  
Robert A. Koeppe ◽  
Thomas Mangner ◽  
A. Lorris Betz ◽  
Barry L. Shulkin ◽  
Richard Allen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Human Brain ◽  
Amino Acid Transport ◽  
Normal Volunteer ◽  
Amino Acid Uptake ◽  
Distribution Volume ◽  
Transport Rate ◽  
Acid Uptake ◽  
Acid Transport ◽  
Influx Rate

A quantitative positron emission tomographic (PET) method to measure amino acid blood–brain barrier (BBB) transport rate and tissue distribution volume (DV) has been developed using 11C-labeled aminocyclohexanecarboxylate (ACHC), a nonmetabolized amino acid analogue. Dynamic PET data were acquired as a series of 15 scans covering a total of 60 min and analyzed by means of a two-compartment, two-parameter model. Functional images were calculated for the amino acid transport rate constants across the BBB and the amino acid DV in the brain. Results show [11C]ACHC to have an influx rate constant in gray matter of ∼0.03–0.04 ml g−1 min−1, indicating a single-pass extraction fraction of ∼5–7%. The intersubject coefficient of variation was ∼15% while intrasubject variability of repeat scans was only slightly greater than 5%. Studies were performed in 15 young normal volunteer control subjects, 5 elderly controls, 7 patients with probable Alzheimer's disease, and one patient with phenylketonuria. Results indicate that [11C]-ACHC will serve as the basis of a method for measuring amino acid transport rate and DV in the normal and pathological human brain.

Low-affinity excitatory amino acid uptake in hippocampal astrocytes: A possible role of Na+/dicarboxylate cotransporters

Glia ◽  
2008 ◽  
Vol 56 (9) ◽  
pp. 990-997 ◽  
Author(s):  
Holten Aleksander Talgøy ◽  
Danbolt Niels Christian ◽  
Shimamoto Keiko ◽  
Gundersen Vidar
Keyword(s):  
Amino Acid ◽  
Excitatory Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Hippocampal Astrocytes

Amino acid uptake into human brain tumors

1974 ◽  
Vol 76 (1) ◽  
pp. 95-107 ◽  
Author(s):  
S. Robert Snodgrass ◽  
L.L. Iversen
Keyword(s):  
Amino Acid ◽  
Brain Tumors ◽  
Human Brain ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Human Brain Tumors
Sign in / Sign up

Export Citation Format

Share Document