Hyper-thermal neutron irradiation field for neutron capture therapy

1994 ◽  
Vol 94 (4) ◽  
pp. 433-440 ◽  
Author(s):  
Yoshinori Sakurai ◽  
Tooru Kobayashi ◽  
Keiji Kanda
Keyword(s):  
Thermal Neutron ◽  
Neutron Irradiation ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Thermal Neutron Irradiation ◽  
Irradiation Field

scholarly journals Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy

2014 ◽  
Vol 50 (82) ◽  
pp. 12325-12328 ◽  
Author(s):  
Shoji Tachikawa ◽  
Tatsuro Miyoshi ◽  
Hayato Koganei ◽  
Mohamed E. El-Zaria ◽  
Clara Viñas ◽  
...  
Keyword(s):  
Thermal Neutron ◽  
Neutron Irradiation ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Tumor Bearing ◽  
Thermal Neutron Irradiation ◽  
Delivery Vehicles

Significant anti-tumor effects and longer survivals were observed in the tumor-bearing mice treated with spermidinium closo-dodecaborate-encapsulating liposomes after thermal neutron irradiation.

Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography

2014 ◽  
Vol 88 ◽  
pp. 153-156 ◽  
Author(s):  
H. Tanaka ◽  
Y. Sakurai ◽  
M. Suzuki ◽  
S. Masunaga ◽  
T. Mitsumoto ◽  
...  
Keyword(s):  
Thermal Neutron ◽  
Neutron Source ◽  
Neutron Irradiation ◽  
Thermal Neutron Irradiation ◽  
Irradiation Field

Synthesis and Biological Behavior of a Boronated Analogue of the Antiestrogen U 23,469-M

1991 ◽  
Vol 46 (3-4) ◽  
pp. 252-256 ◽  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Thermal Neutron ◽  
Therapeutic Effect ◽  
Neutron Capture ◽  
Biological Behavior ◽  
Neutron Capture Therapy ◽  
Thermal Neutron Irradiation ◽  
Estrogen Receptor Positive ◽  
Specific Uptake

A boronated analogue of the antiestrogen U 23,469-M (D. Lednicer, D. W. Emmert, S. C. Lyster, and G. W. Duncan, J. Med. Chem . 12, 881 (1969)) was prepared, for possible use in neutron capture therapy of estrogen receptor-positive tumors. In this analogue, the terminal OH group was replaced by a B-decachloro-o-carboranyl residue. This com pound showed a large, non-specific uptake in ZR75-1 breast cancer-derived cells. It could partially inhibit the uptake of estradiol in these cells. Accumulation in the cells at physiologically obtainable concentrations was, however, too low to envisage a therapeutic effect following thermal neutron irradiation.

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