scholarly journals Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy

2014 ◽  
Vol 50 (82) ◽  
pp. 12325-12328 ◽  
Author(s):  
Shoji Tachikawa ◽  
Tatsuro Miyoshi ◽  
Hayato Koganei ◽  
Mohamed E. El-Zaria ◽  
Clara Viñas ◽  
...  
Keyword(s):  
Thermal Neutron ◽  
Neutron Irradiation ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Tumor Bearing ◽  
Thermal Neutron Irradiation ◽  
Delivery Vehicles

Significant anti-tumor effects and longer survivals were observed in the tumor-bearing mice treated with spermidinium closo-dodecaborate-encapsulating liposomes after thermal neutron irradiation.

Synthesis and Biological Behavior of a Boronated Analogue of the Antiestrogen U 23,469-M

1991 ◽  
Vol 46 (3-4) ◽  
pp. 252-256 ◽  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Thermal Neutron ◽  
Therapeutic Effect ◽  
Neutron Capture ◽  
Biological Behavior ◽  
Neutron Capture Therapy ◽  
Thermal Neutron Irradiation ◽  
Estrogen Receptor Positive ◽  
Specific Uptake

A boronated analogue of the antiestrogen U 23,469-M (D. Lednicer, D. W. Emmert, S. C. Lyster, and G. W. Duncan, J. Med. Chem . 12, 881 (1969)) was prepared, for possible use in neutron capture therapy of estrogen receptor-positive tumors. In this analogue, the terminal OH group was replaced by a B-decachloro-o-carboranyl residue. This com pound showed a large, non-specific uptake in ZR75-1 breast cancer-derived cells. It could partially inhibit the uptake of estradiol in these cells. Accumulation in the cells at physiologically obtainable concentrations was, however, too low to envisage a therapeutic effect following thermal neutron irradiation.

Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model

2021 ◽  
pp. 20210593
Author(s):  
Verónica A. Trivillin ◽  
Yanina V. Langle ◽  
Mónica A. Palmieri ◽  
Emiliano C.C. Pozzi ◽  
Silvia I. Thorp ◽  
...  
Keyword(s):  
Neutron Capture ◽  
Tumor Response ◽  
Local Effect ◽  
Neutron Capture Therapy ◽  
Abscopal Effect ◽  
Tumor Bearing ◽  
Boron Neutron Capture ◽  
Effect Of Treatment ◽  
Draining Lymph Nodes ◽  
Abscopal Effects

We previously demonstrated, for the first time, the abscopal effect of Boron Neutron Capture Therapy (BNCT) in an ectopic model of syngeneic colon cancer in BDIX rats. Objective: The aim of the present study was to evaluate the local and regional therapeutic efficacy and abscopal effect of BNCT mediated by boronophenyl-alanine, combined with Bacillus Calmette-Guerin (BCG) as an immunotherapy agent in this model. Methods: The local effect of treatment was evaluated in terms of tumor response in the irradiated tumor-bearing right hind flank. Metastatic spread to tumor-draining lymph nodes was analyzed as an indicator of regional effect. The abscopal effect of treatment was assessed as tumor growth inhibition in the contralateral (non-irradiated) left hind flank inoculated with tumor cells 2 weeks post-irradiation. The experimental groups BNCT, BNCT + BCG, BCG, Beam only (BO), BO +BCG, SHAM (tumor-bearing, no treatment, same manipulation) were studied. Results: BNCT and BNCT + BCG induced a highly significant local anti-tumor response, whereas BCG alone induced a weak local effect. BCG and BNCT + BCG induced a significant abscopal effect in the contralateral non-irradiated leg. The BNCT + BCG group showed significantly less metastatic spread to tumor-draining lymph nodes vs SHAM and vs BO. Conclusion: This study suggests that BNCT + BCG-immunotherapy would induce local, regional and abscopal effects in tumor-bearing animals. BNCT would be the main effector of the local anti-tumor effect whereas BCG would be the main effector of the abscopal effect. Advances in knowledge: Although the local effect of BNCT has been widely evidenced, this is the first study to show the local, regional and abscopal effects of BNCT combined with immunotherapy, contributing to comprehensive cancer treatment with combined therapies.

Selective Melanoma Thermal Neutron Capture Therapy for Lymph Node Metastases

1993 ◽  
pp. 705-710 ◽  
Author(s):  
Y. Mishima ◽  
C. Honda ◽  
M. Ichihashi ◽  
M. Shiono ◽  
N. Wadabayashi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Thermal Neutron ◽  
Lymph Node Metastases ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Thermal Neutron Capture ◽  
Node Metastases
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