Antitumor effect of DT-5461a, a synthetic low-toxicity lipid a analog, involves endogenous tumor necrosis factor induction subsequent to macrophage activation

Toshihiko Akimoto; Eiji Kumazawa; Takeshi Jimbo; Noriko Joto; Akiko Tohgo

doi:10.1016/0192-0561(94)90043-4

Antitumor effect of DT-5461a, a synthetic low-toxicity lipid a analog, involves endogenous tumor necrosis factor induction subsequent to macrophage activation

International Journal of Immunopharmacology ◽

10.1016/0192-0561(94)90043-4 ◽

1994 ◽

Vol 16 (11) ◽

pp. 887-893 ◽

Cited By ~ 10

Author(s):

Toshihiko Akimoto ◽

Eiji Kumazawa ◽

Takeshi Jimbo ◽

Noriko Joto ◽

Akiko Tohgo

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Macrophage Activation ◽

Antitumor Effect ◽

Lipid A ◽

Low Toxicity ◽

Tumor Necrosis Factor Induction ◽

Necrosis Factor

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Induction of intratumoral tumor necrosis factor by a synthetic lipid A analog, ONO-4007, with less tolerance in repeated administration and its implication in potent antitumor effects with low toxicity

Cancer Immunology Immunotherapy ◽

10.1007/s00262-001-0241-7 ◽

2002 ◽

Vol 50 (12) ◽

pp. 653-662 ◽

Cited By ~ 8

Author(s):

Motonobu Satoh, Kazusa Tsurumaki, Hideaki Ka

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Repeated Administration ◽

Antitumor Effects ◽

Low Toxicity ◽

Necrosis Factor

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Induction of an endogenous tumor necrosis factor in mice by murine recombinant interferon-? combined with a lipid A subunit analog (GLA-60) of low toxicity

Cancer Immunology Immunotherapy ◽

10.1007/bf00199284 ◽

1989 ◽

Vol 29 (2) ◽

Cited By ~ 14

Author(s):

Ikuo Saiki ◽

Hiroaki Maeda ◽

Takuma Sakurai ◽

Jun Murata ◽

Joji Iida ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Recombinant Interferon ◽

A Subunit ◽

Low Toxicity ◽

Necrosis Factor

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Antitumor Effect of DT-5461, a Lipid a Derivative, Against Human Tumor Xenografts Is Mediated by Intratumoral Production of Tumor Necrosis Factor and Affected by Host Immunosuppressive Factors in Nude Mice

Cancer Investigation ◽

10.3109/07357909709047593 ◽

1997 ◽

Vol 15 (6) ◽

pp. 522-530 ◽

Cited By ~ 5

Author(s):

Eiji Kumazawa ◽

Takeshi Jimbo ◽

Toshihiko Akimoto ◽

Noriko Joto ◽

Akiko Tohgo

Keyword(s):

Tumor Necrosis Factor ◽

Nude Mice ◽

Tumor Necrosis ◽

Antitumor Effect ◽

Lipid A ◽

Human Tumor ◽

Human Tumor Xenografts ◽

Tumor Xenografts ◽

Necrosis Factor ◽

Immunosuppressive Factors

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Production of tumor necrosis factor induced by synthetic low-toxicity lipid a analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase—MAP kinase signaling pathway in murine macrophages

Cellular Immunology ◽

10.1016/0008-8749(95)80002-z ◽

1995 ◽

Vol 160 (1) ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Noriko Joto ◽

Toshihiko Akimoto ◽

Kazuhiko Someya ◽

Akiko Tohgo

Keyword(s):

Tumor Necrosis Factor ◽

Tyrosine Kinase ◽

Signaling Pathway ◽

Tumor Necrosis ◽

Lipid A ◽

Receptor Sites ◽

Low Toxicity ◽

Kinase Signaling Pathway ◽

Map Kinase Signaling Pathway ◽

Necrosis Factor

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Hyperthermic Enhancement of the Antitumor Effect of Natural Human Tumor Necrosis Factor-α and -β: anin vitroandin vivoStudy

Japanese Journal of Cancer Research ◽

10.1111/j.1349-7006.1988.tb00074.x ◽

1988 ◽

Vol 79 (9) ◽

pp. 1054-1061 ◽

Cited By ~ 8

Author(s):

Tetsuya Maeda ◽

Sadanori Fuchimoto ◽

Kunzo Orita

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Antitumor Effect ◽

Tumor Necrosis Factor Α ◽

Human Tumor ◽

Human Tumor Necrosis Factor ◽

Factor Α ◽

Necrosis Factor

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Appearance of cytokine-associated central nervous system myelin damage coincides temporally with serum tumor necrosis factor induction after recombinant interleukin-2 infusion in rats

Journal of Neuroimmunology ◽

10.1016/0165-5728(91)90112-k ◽

1991 ◽

Vol 33 (3) ◽

pp. 245-251 ◽

Cited By ~ 24

Author(s):

Mary D. Ellison ◽

Randall E. Merchant

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Interleukin 2 ◽

Recombinant Interleukin 2 ◽

Tumor Necrosis Factor Induction ◽

Necrosis Factor ◽

Serum Tumor Necrosis ◽

Myelin Damage

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Induction of Tumor Necrosis Factor in a Murine Tumor by Systemic Administration of a Novel Synthetic Lipid A Analogue ONO-4007

Journal of Immunotherapy ◽

10.1097/00002371-199701000-00007 ◽

1997 ◽

Vol 20 (1) ◽

pp. 65-66 ◽

Cited By ~ 8

Author(s):

Hiroshi Ueda ◽

Masatoshi Yamazaki

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Systemic Administration ◽

Murine Tumor ◽

Necrosis Factor

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Oncolytic Adenovirus Expressing ST13 Increases Antitumor Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Against Pancreatic Ductal Adenocarcinoma

Human Gene Therapy ◽

10.1089/hum.2020.024 ◽

2020 ◽

Vol 31 (15-16) ◽

pp. 891-903 ◽

Cited By ~ 1

Author(s):

Youni Zhang ◽

Miaojuan Ye ◽

Fang Huang ◽

Shibing Wang ◽

Huiju Wang ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Pancreatic Ductal Adenocarcinoma ◽

Tumor Necrosis ◽

Antitumor Effect ◽

Oncolytic Adenovirus ◽

Ductal Adenocarcinoma ◽

Necrosis Factor

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MONOPHOSPHORYL LIPID A PROTECTS AGAINST GRAM-POSITIVE SEPSIS AND TUMOR NECROSIS FACTOR

Shock ◽

10.1097/00024382-199410000-00007 ◽

1994 ◽

Vol 2 (4) ◽

pp. 271-274 ◽

Cited By ~ 20

Author(s):

Mark E. Astiz ◽

Angel Galera ◽

Dhanonjoy C. Saha ◽

Charles Carpati ◽

Eric C. Rackow

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Gram Positive ◽

Monophosphoryl Lipid A ◽

Monophosphoryl Lipid ◽

Necrosis Factor

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Tumor Necrosis Factor α Mediates the Antitumor Effect of Combined Interleukin-2 and Whole Body Hyperthermia

Journal of Surgical Research ◽

10.1006/jsre.1996.0010 ◽

1996 ◽

Vol 60 (1) ◽

pp. 55-60 ◽

Cited By ~ 1

Author(s):

Kelly L. Fritz ◽

Steven Koziol ◽

Dagmar F. Fabian ◽

Alan T. Lefor

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Antitumor Effect ◽

Tumor Necrosis Factor Α ◽

Interleukin 2 ◽

Whole Body ◽

Whole Body Hyperthermia ◽

Factor Α ◽

Necrosis Factor

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