Early cardiac toxicity of 4′-iodo-4′-deoxydoxorubicin

Daunomycin, an antibiotic used in the clinical management of acute leukemia, produces a delayed, lethal cardiac toxicity. The lethality is dose and schedule dependent; histopathologic changes induced by the drug have been described in heart, lung, and kidney from hamsters in both single and multiple dose studies. Mice given a single intravenous dose of daunomycin (10 mg/kg) die 6-7 days later. Drug distribution studies indicate that the rodents excrete most of a single dose of the drug as daunomycin and metabolite within 48 hours after dosage (M. A. Asbell, personal communication).Myocardium from the ventricles of 6 moribund BDF1 mice which had received a single intravenous dose of daunomycin (10 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde and prepared for electron microscopy.

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Troponin I as a marker of cardiac toxicity in acute colchicine overdose

The American Journal of Emergency Medicine ◽

10.1053/ajem.2000.9278 ◽

2000 ◽

Vol 18 (6) ◽

pp. 0743-0744 ◽

Cited By ~ 1

Author(s):

Michael E. Mullins ◽

Deborah G. Robertson ◽

Robert L. Norton

Keyword(s):

Troponin I ◽

Cardiac Toxicity ◽

Colchicine Overdose

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Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity

Journal of Environmental Pathology Toxicology and Oncology ◽

10.1615/jenvironpatholtoxicoloncol.2019029341 ◽

2019 ◽

Vol 38 (2) ◽

pp. 143-152 ◽

Cited By ~ 5

Author(s):

Miao Chen ◽

Vijaya Paul Samuel ◽

Yi Wu ◽

Minyan Dang ◽

Yukiat Lin ◽

...

Keyword(s):

Cardiac Toxicity ◽

Protective Activity

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The Protective Role of Curcumin and Melatonin in Amelioration of Cadmium- Induced Cardiac Toxicity in Adult Albino Rats

Ain Shams Journal of Forensic Medicine and Clinical Toxicology ◽

10.21608/ajfm.2016.18553 ◽

2016 ◽

Vol 26 (1) ◽

pp. 161-170

Author(s):

Hoda Salah Eldin ◽

Rabab Hafez

Keyword(s):

Cardiac Toxicity ◽

Protective Role ◽

Albino Rats

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Cardiomyocyte-Specific Circulating Cell-Free Methylated DNA in Esophageal Cancer Patients Treated with Chemoradiation

Gastrointestinal Disorders ◽

10.3390/gidisord3030011 ◽

2021 ◽

Vol 3 (3) ◽

pp. 100-112

Author(s):

Sarah Martinez Roth ◽

Eveline E. Vietsch ◽

Megan E. Barefoot ◽

Marcel O. Schmidt ◽

Matthew D. Park ◽

...

Keyword(s):

Esophageal Cancer ◽

Cardiac Toxicity ◽

Amplicon Sequencing ◽

Neoadjuvant Chemoradiation ◽

Patient Specific ◽

High Dose ◽

Specific Cell ◽

Methylated Dna ◽

Bisulfite Treatment ◽

Dose Radiation

Thoracic high-dose radiation therapy (RT) for cancer has been associated with early and late cardiac toxicity. To assess altered rates of cardiomyocyte cell death due to RT we monitored changes in cardiomyocyte-specific, cell-free methylated DNA (cfDNA) shed into the circulation. Eleven patients with distal esophageal cancer treated with neoadjuvant chemoradiation to 50.4 Gy (RT) and concurrent carboplatin and paclitaxel were enrolled. Subjects underwent fasting blood draws prior to the initiation and after completion of RT as well as 4–6 months following RT. An island of six unmethylated CpGs in the FAM101A locus was used to identify cardiomyocyte-specific cfDNA in serum. After bisulfite treatment this specific cfDNA was quantified by amplicon sequencing at a depth of >35,000 reads/molecule. Cardiomyocyte-specific cfDNA was detectable before RT in the majority of patient samples and showed some distinct changes during the course of treatment and recovery. We propose that patient-specific cardiac damages in response to the treatment are indicated by these changes although co-morbidities may obscure treatment-specific events.

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Malignant pericardial effusion complicated by cardiac tamponade under atezolizumab

SAGE Open Medical Case Reports ◽

10.1177/2050313x211036005 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110360

Author(s):

Lardinois Benjamin ◽

Goeminne Jean-Charles ◽

Miller Laurence ◽

Randazzo Adrien ◽

Laurent Terry ◽

...

Keyword(s):

Pericardial Effusion ◽

Cardiac Tamponade ◽

Cardiac Toxicity ◽

Checkpoint Inhibitors ◽

Final Diagnosis ◽

Pericardial Fluid ◽

Malignant Pericardial Effusion ◽

Typical Cell ◽

High Fluorescence ◽

Tomography Scan

Immune-related adverse events including cardiac toxicity are increasingly described in patients receiving immune checkpoint inhibitors. We described a malignant pericardial effusion complicated by a cardiac tamponade in an advanced non-small cell lung cancer patient who had received five infusions of atezolizumab, a PDL-1 monoclonal antibody, in combination with cabozantinib. The definitive diagnosis was quickly made by cytology examination showing typical cell abnormalities and high fluorescence cell information provided by the hematology analyzer. The administration of atezolizumab and cabozantinib was temporarily discontinued due to cardiogenic hepatic failure following cardiac tamponade. After the re-initiation of the treatment, pericardial effusion relapsed. In this patient, the analysis of the pericardial fluid led to the final diagnosis of pericardial tumor progression. This was afterwards confirmed by the finding of proliferating intrapericardial tissue by computed tomography scan and ultrasound. This report emphasizes the value of cytology analysis performed in a hematology laboratory as an accurate and immediate tool for malignancy detection in pericardial effusions.

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