Carcinogenicity study of the emulsifier TOSOM and the release agent TOS in Wistar rats

In a 2-year carcinogenicity study, we identified a spontaneous cholangiofibrosis in a control male Wistar rat. This lesion has long been considered as a compound-related change, with no spontaneous cases reported in the Wistar rat. In addition to routine hematoxylin and eosin stains evaluation, we applied Masson’s trichrome staining, Alcian blue-periodic acid–Schiff staining, and OV-6 immunohistochemistry staining. The special staining demonstrated the fibrous component in the interstitium and intestinal metaplasia of the epithelium (presence of goblet cells), while the positive anti-OV-6 reaction indicated the bile duct origin of the epithelium. These results help to confirm the diagnosis of cholangiofibrosis in this case. We report this rare case to alert pathologists that spontaneous cholangiofibrosis does occur in Wistar rats.

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Trimethylphosphate: A 30-Month Chronic Toxicity/Carcinogenicity Study in Wistar Rats with Administration in Drinking Water,

Fundamental and Applied Toxicology ◽

10.1006/faat.1997.2374 ◽

1997 ◽

Vol 40 (1) ◽

pp. 75-89 ◽

Cited By ~ 7

Author(s):

E Bomhard

Keyword(s):

Drinking Water ◽

Wistar Rats ◽

Chronic Toxicity ◽

Carcinogenicity Study

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Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in Wistar rats

Journal of Applied Toxicology ◽

10.1002/jat.1776 ◽

2011 ◽

Vol 33 (7) ◽

pp. 593-606 ◽

Cited By ~ 7

Author(s):

Darol Dodd ◽

Gabrielle Willson ◽

Horace Parkinson ◽

Edilberto Bermudez

Keyword(s):

Drinking Water ◽

Wistar Rats ◽

Methyl Tertiary Butyl Ether ◽

Butyl Ether ◽

Tertiary Butyl ◽

Carcinogenicity Study

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Inhalation carcinogenicity study with nickel metal powder in Wistar rats

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2008.08.017 ◽

2008 ◽

Vol 233 (2) ◽

pp. 262-275 ◽

Cited By ~ 36

Author(s):

Adriana R. Oller ◽

Daniel T. Kirkpatrick ◽

Ann Radovsky ◽

Hudson K. Bates

Keyword(s):

Metal Powder ◽

Wistar Rats ◽

Nickel Metal ◽

Carcinogenicity Study

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Carcinogenicity Study of 3-(5-Nitro-2-Furyl)-Imidazo(1,2-α) Pyridine in Mice and Rats

Tumori Journal ◽

10.1177/030089168006600201 ◽

1980 ◽

Vol 66 (2) ◽

pp. 131-144 ◽

Cited By ~ 1

Author(s):

José R. Cabral ◽

Lorenzo Rossi ◽

Tommaso A. Dragani ◽

Giuseppe Delia Porta

Keyword(s):

Wistar Rats ◽

Female Rats ◽

High Dose ◽

Short Term ◽

Kidney Tumors ◽

Carcinogenicity Study ◽

Male And Female Rats ◽

Term Administration ◽

Dose Levels

3-(5-nitro-2-furyl)-imidazo(1,2-α)pyridine was tested for carcinogenicity by long-term administration in the diet to CTM mice at 0.1, 0.2 and 0.4 % dose levels and to Wistar rats at 0.2 and 0.4 % dose levels, and by short-term intraperitoneal injections to suckling BALB/c mice. The compound was a strong carcinogen. In CTM mice it induced carcinomas of the esophagus and forestomach at all dose levels and thymic lymphosarcomas at the two highest doses. In male and female rats, esophagus and forestomach papillomas were observed at all dose levels, whereas esophagus and forestomach carcinomas and kidney tumors were observed only at the high dose. In female rats, an increased incidence of mammary tumors was seen at the high dose. The treatment of BALB/c suckling mice by intraperitoneal injections did not induce a clear carcinogenic response.

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Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053747 ◽

1982 ◽

Vol 40 ◽

pp. 216-217

Author(s):

D. J. McComb ◽

J. Beri ◽

F. Zak ◽

K. Kovacs

Keyword(s):

Microscopic Study ◽

Pituitary Adenomas ◽

Wistar Rats ◽

Microscopic Level ◽

Sprague Dawley ◽

Prolactin Cells ◽

Light Microscopic Level ◽

Ultrastructural Investigation ◽

Sprague Dawley Rats ◽

Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

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