MANIFESTAÇÕES PATOLÓGICAS EM POSTES DE CONCRETO ARMADO EM DECORRÊNCIA DO SEU PROCESSO PRODUTIVO

Pathological manifestations originate mainly in the production process of the poles, and knowing which measures can be taken in the production process to avoid pathological manifestations in the poles is the main problem. The purpose of this research is to elaborate these measures that will mitigate the pathological manifestations present in the company, which are blisters, spots and segregation. For this, the entire fabrication will be evaluated, making a follow-up from the project, assembling the reinforcement, preparing the concrete, launching, densification and storage of the posts, and then the pathological manifestations in the parts that had their manufacturing process will be analyzed. accompanied, verifying the cause and effect relationship, to then elaborate necessary measures to minimize these problems of the produced poles. For this, service verification sheets, test reports and projects provided by the company will be used. That done, it was observed that the company was using burnt oil as a release agent and did not perform an adequate cleaning of the forms, resulting in dark spots on the posts and bubbles, and these still found a relationship with the wrong launch and thickening. Other than that, it was observed that segregation was directly related to the leakage of forms. With this, it is known that the mitigation of the company's pathological manifestations will be done with the use of an appropriate release agent, an adequate cleaning of the forms and its correct sealing, the densification of the concrete with sufficient number of vibrators for its uniform densification together with the training of the employees responsible for concreting the posts.

Formulation, Optimization and Evaluation of Niosomes Containing Leaf Extract of Moringa oleifera and Pharmacological Screening of the Extract against Rheumatoid Arthritis

This research is formulated on the basis of the Rheumatoid Arthritis of a niosome that contains leaf extract of the herb. Therefore, in this part along with the medication system of the herb on the body, the pharmacologic testing procedure is clarified. In the following part, we will explore a thorough assessment of the condition, called rheumatoid arthritis and how the medicinal plant is used as a release agent. While focusing on rheumatoid arthritis throughout the discussion, the research discussion section has made it clear how effectively this paper has tried to meet the formation of niosome with Moringa extract and its effectiveness to reduce the pain. Furthermore, the entire analysis has been illustrated by focusing on the effect of Moringa oleifera over rheumatoid arthritis disease.

Study on pharmacokinetics of nimodipine nano-controlled release agent modified by host-guest reaction of β-cyclodextrin in rats

Nimodipine (NIMO) has been identified as a second-generation dihydropyridine calcium channel antagonist. NIMO’s specificity for the cerebrovascular smooth muscle contributes to its broad usage in treating ischemic cerebrovascular diseases in the elderly. Therefore, enhancing NIMO’s therapeutic effect and reducing its adverse reactions caused by short-term repeated use have become a focus of research. As a result, a new controlled-release preparation of NIMO, the carboxymethyl chitosan/nimodipine-hydroxypropyl-β-cyclodextrin nanoparticle (Nano-NIMO), was constructed based on hydroxypropyl-β-cyclodextrin. The novel composite Nano-NIMO preparation could significantly improve the stability of NIMO in rat plasma, achieving an absolute bioavailability as high as 62.3%, which is three times that of the traditional NIMO oral preparation. Therefore, Nano-NIMO is expected to provide a new direction for the preparation of modified controlled-release Nano- NIMO agents.