Can phase response curves of various treatments of circadian rhythms be explained by effects on protein synthesis and degradation?

Biosystems ◽  
1982 ◽  
Vol 15 (1) ◽  
pp. 35-47 ◽  
Author(s):  
G. Cornelius ◽  
L. Rensing
Keyword(s):  
Protein Synthesis ◽  
Circadian Rhythms ◽  
Phase Response ◽  
Response Curves ◽  
Phase Response Curves ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation

scholarly journals Roles for ClpXP in regulating the circadian clock in Synechococcus elongatus

2018 ◽  
Vol 115 (33) ◽  
pp. E7805-E7813 ◽  
Author(s):  
Susan E. Cohen ◽  
Briana M. McKnight ◽  
Susan S. Golden
Keyword(s):  
Gene Expression ◽  
Protein Synthesis ◽  
Cell Division ◽  
Circadian Rhythms ◽  
External Environment ◽  
Long Period ◽  
Protein Synthesis And Degradation ◽  
Synthesis And Degradation

In cyanobacteria, the KaiABC posttranslational oscillator drives circadian rhythms of gene expression and controls the timing of cell division. The Kai-based oscillator can be reconstituted in vitro, demonstrating that the clock can run without protein synthesis and degradation; however, protein degradation is known to be important for clock function in vivo. Here, we report that strains deficient in the ClpXP1P2 protease have, in addition to known long-period circadian rhythms, an exaggerated ability to synchronize with the external environment (reduced “jetlag”) compared with WT strains. Deletion of the ClpX chaperone, but not the protease subunits ClpP1 or ClpP2, results in cell division defects in a manner that is dependent on the expression of a dusk-peaking factor. We propose that chaperone activities of ClpX are required to coordinate clock control of cell division whereas the protease activities of the ClpXP1P2 complex are required to maintain appropriate periodicity of the clock and its synchronization with the external environment.

Robotics Application of a Method for Analytically Computing Infinitesimal Phase Response Curves

2020 ◽  
pp. 104-115
Author(s):  
Marshaun N. Fitzpatrick ◽  
Yangyang Wang ◽  
Peter J. Thomas ◽  
Roger D. Quinn ◽  
Nicholas S. Szczecinski
Keyword(s):  
Phase Response ◽  
Response Curves ◽  
Phase Response Curves
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