Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level

1990 ◽  
Vol 111 (3) ◽  
pp. 303-308 ◽  
Author(s):  
Hubert H.M. van Tol ◽  
Marco Riva ◽  
O. Civelli ◽  
Ian Creese
2010 ◽  
Vol 168 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Masaki Nakano ◽  
Itaru Hasunuma ◽  
Reiko Okada ◽  
Kazutoshi Yamamoto ◽  
Sakae Kikuyama ◽  
...  

1997 ◽  
Vol 82 (6) ◽  
pp. 1926-1931 ◽  
Author(s):  
Nobuharu Fujii ◽  
Takeshi Shibata ◽  
Sachiko Homma ◽  
Haruo Ikegami ◽  
Kazuo Murakami ◽  
...  

Fujii, Nobuharu, Takeshi Shibata, Sachiko Homma, Haruo Ikegami, Kazuo Murakami, and Hitoshi Miyazaki. Exercise-induced changes in β-adrenergic-receptor mRNA level measured by competitive RT-PCR. J. Appl. Physiol. 82(6): 1926–1931, 1997.—Competitive reverse transcription-polymerase chain reaction (RT-PCR) analysis was used to clarify whether dynamic exercise-induced increases in β-adrenergic-receptor (β-AR) number in human lymphocytes are accompanied by increases in the β-AR mRNA level. Sixteen healthy subjects performed cycle ergometry until exhaustion. Before and immediately after exercise, peripheral blood was drawn from a forearm vein for preparation of lymphocytes. Both the β-AR mRNA level and the β-AR number were significantly increased by exercise. The changes in β-AR mRNA level and β-AR number were significantly correlated ( r = 0.63, P < 0.01). This finding suggests that a rapid increase in β-AR mRNA level might be an early adaptive response of the sympathetic nervous system to dynamic exercise. In vitro incubation of lymphocytes with epinephrine had no effect on β-AR mRNA levels, nor did adenosine 3′,5′-cyclic monophosphate, protein kinase C, or intracellular Ca2+ increase the β-AR mRNA level in vitro. Therefore, it appears that other mechanisms underlie the exercise-induced elevation of β-AR mRNA levels in human lymphocytes.


2002 ◽  
Vol 104 (1-3) ◽  
pp. 145-151 ◽  
Author(s):  
Tatsuhiko Kurose ◽  
Yoichi Ueta ◽  
Yukiyo Yamamoto ◽  
Ryota Serino ◽  
Yumi Ozaki ◽  
...  

1987 ◽  
Vol 435 (1-2) ◽  
pp. 147-152 ◽  
Author(s):  
Emilio Merlo Pich ◽  
Fabio Benfenati ◽  
Costanza Farabegoli ◽  
Kjell Fuxe ◽  
Emanuel Meller ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document