The long-term results of chymopapain chemonucleolysis for lumbar disc disease

Pain ◽  
1987 ◽  
Vol 30 (1) ◽  
pp. 135
Author(s):  
R. J. Maciunas ◽  
B. N. Onofrio
Keyword(s):  
Lumbar Disc ◽  
Long Term Results ◽  
Disc Disease ◽  
Lumbar Disc Disease

The long-term results of chymopapain chemonucleolysis for lumbar disc disease

1986 ◽  
Vol 65 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Robert J. Maciunas ◽  
Burton M. Onofrio
Keyword(s):  
Surgical Procedures ◽  
Lumbar Disc ◽  
Leg Pain ◽  
Long Term Results ◽  
Disc Disease ◽  
Lumbar Disc Disease ◽  
Content Type ◽  
Work Related ◽  
Effective Treatment Modality

✓ The long-term clinical outcome is evaluated for 268 patients after chymopapain chemonucleolysis for radicular complaints referrable to documented intervertebral disc disease. The follow-up period for 92% of these patients was 10 years. No complications due to chymopapain toxicity were observed; 80.1% of patients were relieved of their presenting radicular leg pain and 75.1% were employed at a capacity equal to or more strenuous than before injection. Chemonucleolysis was demonstrated to be a safe and effective treatment modality, with long-term results that compare favorably with those of similarly selected patients undergoing open surgical procedures. In the patients whose chymopapain therapy failed, the outcome of subsequent open surgical procedures was not necessarily compromised by prior chemonucleolysis. A higher rate of failure and subsequent surgical intervention was seen in those patients with injections performed soon after an unsuccessful open procedure on the same side and at the same interspace, those with workmen's compensation or litigation pending, those with a history of work-related injury, those whose employment involved heavy manual labor or extensive driving, and those whose preinjection spine x-ray films indicated retrograde spondylolisthesis.

scholarly journals Long term results of Endoscopic Lumbar Discectomy using Side viewing Conical working tube

2018 ◽  
Vol 32 (2) ◽  
pp. 306-313
Author(s):  
Mohammad Kaif ◽  
Kuldeep Yadav ◽  
Mazhar Husain
Keyword(s):  
Low Cost ◽  
Lumbar Disc ◽  
Early Mobilization ◽  
Long Term Results ◽  
Disc Disease ◽  
Lumbar Disc Disease ◽  
Endoscopic Discectomy ◽  
Endoscopic Lumbar Discectomy

Abstract Object: Endoscopic discectomy is a common procure performed worldwide with various devices being used and studies have reported their long term results. In this study we present the long term results of the unique device with separate side viewing channel. Methods: 66 patients of lumbar disc herniation treated between March 2009 to April 2012 using the unique conical working tube with separate side viewing endoscopic channel. Their preoperative and postoperative Oswestry Disability Index (ODI) and Macnab scores were used to evaluate the outcome after a minimum follow of 5 years with mean follow up of 76.18 months. Results: There were 46 males and 20 females with age ranging from19-72 (mean-38.4 years). The follow up ranged from 61 months to 95 months with mean of 76.18 months. The mean preoperative ODI score was 74.7 which decreased to a mean of 7.8 and the outcome evaluated by Macnab criteria was 69.69% excellent, 17 % good, 10% fair, 3.03% poor. 2 patients underwent second surgery. None of the patient had to change their occupation due to their lumbar disc disease. Complications occurred were dural tear in 2 patients, transient foot paresis in 1 patient and 1 discitis in 1 patient which improved on medical management. Conclusion: Endoscopic discectomy using thins Conical working tube is a safe and effective technique for lumbar disc prolapse. It has the advantage for early mobilization, short hospital stay and low cost. The long term results are comparable to the conventional techniques.

scholarly journals A Retrospective Observational Analysis on the Outcome of Microlumbar Discectomy among 70 Consecutive Cases in the Tertiary Care Spine Center in Nepal

2019 ◽  
Vol 16 (3) ◽  
pp. 34-39
Author(s):  
Binod Bhattarai ◽  
Shashi Bhushan Sah
Keyword(s):  
Wound Infection ◽  
Lumbar Disc ◽  
Tertiary Care ◽  
Lumbar Discectomy ◽  
Neurological Deficits ◽  
Disc Disease ◽  
Term Outcome ◽  
Lumbar Disc Disease ◽  
Long Term Outcome

Lumbar disc disease is a commonly encountered spine problem. There have been various modalities of treatment that have evolved over the years. The objective of our study is to analyze safety, efficacy, and complications following Micro-lumbar discectomy. All the cases admitted in our spine clinic with symptomatic lumbar disc and who underwent Micro-lumbar discectomy between February2013 to February 2018 were included in our study. Seventy cases were operated during this period. Total operative time, immediate and long term outcome with regards to pain and neurological deficits were tabulated and analyzed for each patient. Furthermore, short and long term complications including wound infection, discit is, instability and recurrence at the same level were also studied and compared with similar studies from the literature. None of our cases had complications related to wound infection, instability or post-operativediscitis. Immediate relief from the radicular pain experienced in the pre-operative period was seen in all patients (Visual analog scale) though benign tingling sensation persisted in a few of them that improved in a short span of time. Recurrence was seen in only one case. Micro-lumbar discectomy is a minimally invasive spine procedure conferring high benefits to the patients. While compared to other methods of intervention, it has a low risk of complications as well as chances of disc recurrences.

Chemonucleolysis with chymopapain: results in 150 patients

1987 ◽  
Vol 67 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Christopher B. Shields ◽  
Steven J. Reiss ◽  
Henry D. Garretson
Keyword(s):  
Lumbar Disc ◽  
Third Party ◽  
Daily Activities ◽  
Mail Questionnaire ◽  
Disc Disease ◽  
Lumbar Disc Disease ◽  
Content Type ◽  
Cast Doubt ◽  
Mild Restriction

✓ Chemonucleolysis with chymopapain has been advocated for the treatment of lumbar disc disease. When polled by a mail questionnaire, 150 consecutive patients who had undergone chemonucleolysis reported an overall success rate of only 40% and a failure rate of 60%. However, 57% of the patients were active or had only mild restriction of daily activities. Of those patients employed prior to injection, only 63% had returned to work. Those with workmen's compensation benefits fared considerably worse than those covered by third-party insurance (17% vs. 51% success). These results cast doubt on the long-term benefits of chymopapain in the treatment of lumbar disc disease.

scholarly journals Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

2021 ◽  
pp. 219256822199836
Author(s):  
Sathish Muthu ◽  
Madhan Jeyaraman ◽  
Girinivasan Chellamuthu ◽  
Naveen Jeyaraman ◽  
Rashmi Jain ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Platelet Rich Plasma ◽  
Lumbar Disc ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
Disc Disease ◽  
Lumbar Disc Disease ◽  
Beneficial Role ◽  
Sf 36

Study Design: Systematic review and meta-analysis. Objectives: We performed this meta-analysis to evaluate whether intradiscal Platelet Rich Plasma(PRP) injection has any beneficial role in the management of lumbar disc disease. Methods: We conducted independent and duplicate electronic database searches including PubMed, Embase, and Cochrane Library till September 2020 for studies investigating the role of intradiscal PRP in the management of lumbar disc disease. The analysis was performed in the R platform using OpenMeta[Analyst] software. Results: 13 studies including 2 RCTs, 5 prospective, and 6 retrospective studies involving 319 patients were included in the meta-analysis. A single-arm meta-analysis of the included studies showed a beneficial effect of the intervention in terms of pain relief outcomes like VAS score (p < 0.001), pain component of SF-36 (p = 0.003) while such improvement was not seen in functional outcome measures like ODI score (p = 0.071), the physical component of SF-36 (p = 0.130) with significant heterogeneity noted among the included studies. No structural improvement in magnetic resonance imaging was observed (p = 0.106). No additional procedure-related adverse events were noted in the included studies (p = 0.662). Conclusion: There is a paucity of high-quality studies to give conclusive evidence on the benefits of intradiscal PRP for lumbar disc disease. Although intradiscal PRP injection has shown some beneficial effect in controlling pain for lumbar disc disease, we could not find structural or functional improvement from the included studies. Hence, we recommend large double-blind double-arm randomized controlled studies to analyze the benefits of the intervention being analyzed.

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