The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

This case focuses on pain hypersensitivity by asking the question: Are primary afferent-induced hypersensitivity states dependent on the activation of N-methyl-d-aspartate (NMDA) receptors, and is windup (perceived increase in pain intensity with a repeatedly delivered stimulus) a possible trigger for the production of central hypersensitivity? This study demonstrated that the induction and maintenance of central sensitization are dependent on NMDA receptor activation. NMDA receptor antagonists have been shown to prevent the manifestation of central sensitization as well as to decrease established hyperactivity in pain pathways. NMDA receptor antagonists play an important role in pain management.

Download Full-text

Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: Involvement of LPA receptors

Molecules and Cells ◽

10.1007/s10059-012-0254-4 ◽

2012 ◽

Vol 34 (6) ◽

pp. 563-572 ◽

Cited By ~ 31

Author(s):

Tae-Joon Shin ◽

Hyeon-Joong Kim ◽

Byeong-Jae Kwon ◽

Sun-Hye Choi ◽

Hyun-Bum Kim ◽

...

Keyword(s):

Aspartic Acid ◽

Long Term Potentiation ◽

Receptor Activation ◽

Acid Receptor ◽

Term Potentiation ◽

Lpa Receptors

Download Full-text

Involvement of N-Methyl-D-Aspartic Acid Receptor Activation in Oxytocin and Vasopressin Release After Osmotic Stimuli in Rats

Journal of Neuroendocrinology ◽

10.1046/j.1365-2826.2001.00607.x ◽

2001 ◽

Vol 13 (2) ◽

pp. 166-174 ◽

Cited By ~ 25

Author(s):

T. Onaka ◽

K. Yagi

Keyword(s):

Aspartic Acid ◽

Receptor Activation ◽

Vasopressin Release ◽

Acid Receptor ◽

Osmotic Stimuli

Download Full-text

Dorsal Horn α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Trafficking in Inflammatory Pain

Anesthesiology ◽

10.1097/aln.0b013e3181d3e1ed ◽

2010 ◽

Vol 112 (5) ◽

pp. 1259-1265 ◽

Cited By ~ 38

Author(s):

Yuan-Xiang Tao ◽

David S. Warner

Keyword(s):

Dorsal Horn ◽

Aspartic Acid ◽

Central Sensitization ◽

Inflammatory Pain ◽

Persistent Pain ◽

Receptor Trafficking ◽

Current Evidence ◽

Receptor Subunit ◽

Acid Receptor ◽

Dorsal Horn Neurons

Activation of synaptic N-methyl-D-aspartic acid receptor and its intracellular downstream signals in dorsal horn neurons of spinal cord contribute to central sensitization, a mechanism that underlies the development and maintenance of pain hypersensitivity in persistent pain. However, the molecular process of this event is not understood completely. Recently, new studies suggest that peripheral inflammatory insults drive changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit trafficking via N-methyl-D-aspartic acid receptor-triggered activation of protein kinases in dorsal horn and raise the possibility that such changes might contribute to central sensitization in persistent pain. This review presents current evidence regarding the changes that occur in the trafficking of dorsal horn alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits GluR1 and GluR2 under persistent inflammatory pain conditions and discusses the potential mechanisms by which such changes participate in the development and maintenance of inflammatory pain.

Download Full-text