Synaptology and sources of vasoactive intestinal polypeptide and substance p containing axons of the cat celiac ganglion. An experimental electron microscopic immunohistochemical study

Neuroscience ◽  
1983 ◽  
Vol 10 (3) ◽  
pp. 947-958 ◽  
Author(s):  
C. Léránth ◽  
E. Fehér
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Immunohistochemical Study ◽  
Electron Microscopic ◽  
Celiac Ganglion ◽  
Intestinal Polypeptide

scholarly journals A Light and Electron Microscopic Immunohistochemical Study of Vasoactive Intestinal Polypeptide— And Substance P-Containing Nerve Fibers along the Cerebral Blood Vessels: Comparison with Aminergic and Cholinergic Nerve Fibers

1984 ◽  
Vol 4 (3) ◽  
pp. 407-414 ◽  
Author(s):  
Toru Itakura ◽  
Takashi Okuno ◽  
Kazuo Nakakita ◽  
Ichiro Kamei ◽  
Yutaka Naka ◽  
...  
Keyword(s):  
Substance P ◽  
Blood Vessels ◽  
Vasoactive Intestinal Polypeptide ◽  
Electron Microscopic Observation ◽  
Nerve Fibers ◽  
Muscle Control ◽  
Cerebral Blood Vessels ◽  
Electron Microscopic ◽  
Cholinergic Nerve Fibers ◽  
Intestinal Polypeptide

Vasoactive intestinal polypeptide (VIP)– and substance P–containing nerve fibers were observed in the cerebral blood vessels using an immunohistochemical technique. VIP-containing nerve fibers distributed in a spiral pattern, similar to that of muscle cells. Under electron microscopic observation, VIP-immunoreactive terminals lay close to a muscle cell in the inner layer of the adventitia. In contrast, substance P–containing nerve fibers showed a meshwork pattern in the outer layer of the adventitia. Using both acetylcholinesterase (AChE) staining and VIP immunohistochemistry, AChE-positive and VIP-immunoreactive nerve fibers revealed almost the same distribution in the same specimen. The present data suggest that VIP-containing nerve fibers may play a role in the smooth muscle control of the blood vessels, whereas substance P–containing nerve fibers may not take part in muscle control.

scholarly journals Innervation of the pancreas by substance P, enkephalin, vasoactive intestinal polypeptide and gastrin/CCK immunoractive nerves.

1979 ◽  
Vol 27 (9) ◽  
pp. 1283-1284 ◽  
Author(s):  
L I Larsson
Keyword(s):  
Blood Flow ◽  
Insulin Secretion ◽  
Substance P ◽  
Blood Vessels ◽  
Vasoactive Intestinal Polypeptide ◽  
Pancreatic Blood Flow ◽  
Major Site ◽  
Site Of Action ◽  
Immunocytochemical Studies ◽  
Intestinal Polypeptide

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.

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