A new simulation technique called the system modal approximation method (SMA) for fluid transients in complex pipeline systems has been proposed. The superiority of this technique compared to other existing methods has been verified. Thus far, however, detailed considerations have been limited to pipelines having elementary boundary conditions. In the present paper, for the generalization of the SMA method, calculation methods are newly proposed for the case in which the boundary conditions are given by the time-variant nonlinear relationship between pressure and flow rate, such as the conditions in a safety valve, and its usefulness is verified by comparison to experimental measurements.