Effects of acute inorganic lead administration on in vivo drug metabolism and cytochrome P-450 in the rat

1978 ◽  
Vol 2 (6) ◽  
pp. 361-364 ◽  
Author(s):  
Jerry J. Hjelle ◽  
Miftah Kemal ◽  
Alphonse Poklis
Keyword(s):  
Drug Metabolism ◽  
Inorganic Lead ◽  
Cytochrome P 450 ◽  
In Vivo Drug Metabolism

Evaluation of rat brain subcellular fractions for the prediction of in vivo drug metabolism in brain

2018 ◽  
Vol 33 (1) ◽  
pp. S79 ◽  
Author(s):  
Mohammad Shadid ◽  
Ying Liu ◽  
Elvana Veizaj ◽  
Jiansheng Huang ◽  
Josh Johnson ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Rat Brain ◽  
Subcellular Fractions ◽  
In Vivo Drug Metabolism

scholarly journals Visualizing Drug Efficacy In Vivo

2005 ◽  
Vol 4 (2) ◽  
pp. 153535002005051 ◽  
Author(s):  
Weisheng Zhang ◽  
Min Chen ◽  
David B. West ◽  
Anthony F. Purchio
Keyword(s):  
Enzyme Activity ◽  
Drug Metabolism ◽  
Drug Effects ◽  
Study Drug ◽  
Drug Efficacy ◽  
Biochemical Assays ◽  
Metabolism Enzymes ◽  
First Time ◽  
Cytochrome P 450

Many enzymes are therapeutic targets for drug discovery, whereas other enzymes are important for understanding drug metabolism and pharmacokinetics during compound testing in animals. Testing of drug efficacy and metabolism in an animal model requires the measurement of disease endpoints as well as assays of enzyme activity in specific tissues at selected time points during treatment. This requires the removal of tissue and biochemical assays. Techniques to noninvasively assess drug effects on enzyme activity using imaging technology would facilitate understanding of drug efficacy, pharmacokinetics, and drug metabolism. Using a commercially available cytochrome P−450 3A substrate whose oxidized product is a luciferase substrate, we show for the first time that cytochrome P−450 enzyme activity can be measured in vivo in real time by bioluminescent imaging. This imaging approach could be applicable to study drug effects on therapeutic target enzymes, as well as drug metabolism enzymes.

scholarly journals In vivo drug metabolism in experimental cholestatic models

1978 ◽  
Vol 74 (5) ◽  
pp. 1112
Author(s):  
R.A. Willson ◽  
F.E. Hart ◽  
J.T. Hew
Keyword(s):  
Drug Metabolism ◽  
In Vivo Drug Metabolism

Comparison of in Vitro Preparations for Semi-Quantitative Prediction of in Vivo Drug Metabolism

2002 ◽  
Vol 30 (10) ◽  
pp. 1129-1136 ◽  
Author(s):  
I. A. M. de Graaf ◽  
C. E. van Meijeren ◽  
F. Pektaş ◽  
H. J. Koster
Keyword(s):  
Drug Metabolism ◽  
Quantitative Prediction ◽  
In Vivo Drug Metabolism
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