scholarly journals Fluconazole: A Potent Inhibitor of Cytochrome P-450-Dependent Drug-Metabolism in Mice and Humans in Vivo. Comparative Study with Ketoconazole.

1992 ◽  
Vol 40 (5) ◽  
pp. 1247-1251 ◽  
Author(s):  
Kunihiko MORITA ◽  
Hiroki KONISHI ◽  
Harumi SHIMAKAWA
Keyword(s):  
Drug Metabolism ◽  
Comparative Study ◽  
Potent Inhibitor ◽  
Cytochrome P 450

A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats

1970 ◽  
Vol 9 (1) ◽  
pp. 99-105 ◽  
Author(s):  
C. Von Bahr ◽  
B. Alexanderson ◽  
D.L. Azarnoff ◽  
F. Sjöqvist ◽  
S. Orrenius
Keyword(s):  
Drug Metabolism ◽  
Comparative Study ◽  
Perfused Liver ◽  
Isolated Perfused Liver

scholarly journals Visualizing Drug Efficacy In Vivo

2005 ◽  
Vol 4 (2) ◽  
pp. 153535002005051 ◽  
Author(s):  
Weisheng Zhang ◽  
Min Chen ◽  
David B. West ◽  
Anthony F. Purchio
Keyword(s):  
Enzyme Activity ◽  
Drug Metabolism ◽  
Drug Effects ◽  
Study Drug ◽  
Drug Efficacy ◽  
Biochemical Assays ◽  
Metabolism Enzymes ◽  
First Time ◽  
Cytochrome P 450

Many enzymes are therapeutic targets for drug discovery, whereas other enzymes are important for understanding drug metabolism and pharmacokinetics during compound testing in animals. Testing of drug efficacy and metabolism in an animal model requires the measurement of disease endpoints as well as assays of enzyme activity in specific tissues at selected time points during treatment. This requires the removal of tissue and biochemical assays. Techniques to noninvasively assess drug effects on enzyme activity using imaging technology would facilitate understanding of drug efficacy, pharmacokinetics, and drug metabolism. Using a commercially available cytochrome P−450 3A substrate whose oxidized product is a luciferase substrate, we show for the first time that cytochrome P−450 enzyme activity can be measured in vivo in real time by bioluminescent imaging. This imaging approach could be applicable to study drug effects on therapeutic target enzymes, as well as drug metabolism enzymes.

790: BMP-7 is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 255-256
Author(s):  
Cyrill A. Rentsch ◽  
Jeroen Buijs ◽  
Geertje Van der Horst ◽  
Petra Van Overveld ◽  
Antoinette Wetterwald ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Potent Inhibitor

A Comparative Study of the in vivo Distribution of 32P-Polyphosphates and 32P-Orthophosphate

1972 ◽  
Vol 11 (01) ◽  
pp. 70-78
Author(s):  
Esther Miller ◽  
Leopoldo Anghileri
Keyword(s):  
Radiation Dose ◽  
Comparative Study ◽  
Soft Tissues ◽  
Tumor Bearing ◽  
In Vivo Distribution ◽  
The Cross ◽  
Total Body

SummaryThe distribution of 32P-polyphosphates (lineal and cross-linked) and 32Porthophosphate in normal and tumor bearing animals has been studied. Differences between the cross-linked and the lineal form are related to a different degree of susceptibility to the hydrolysis by the phosphatases. In contrast to orthophosphate, the polyphosphates showed a lower accumulation in soft tissues which gives an advantageous reduction of the total body radiation dose.

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