Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as μ-type opioids

Background: Unexplained fatigue is a common complaint. When underlying disease causes have been eliminated, lifestyle measures and supplementation can be indicated. Elaborating on clinical findings that G115®, a dry extract from the root of Panax ginseng, combined with vitamins and minerals could alleviate fatigue, this open label study aimed at assessing its effect on perceived fatigue and energy. Methods: Healthy adults self-reporting fatigue (n = 103) completed the Multidimensional Fatigue Inventory questionnaire. They rated their perceptions of mental and physical fatigue, energy, performance, and stress at baseline and 15, 30, 60 and 90 days after a daily intake of 40 mg G115® formulated with vitamins and minerals. Results: Compared with baseline values, mean self-perception of general fatigue was reduced by −7.55 units [95% CI: −8.44; −6.66] (−41.8%, p < 0.0001) at 90 days. All assessed perception ratings (mental and physical fatigue, reduced activity and motivation, performance, and stress) were significantly and steadily improved from two weeks after supplementation up to study’s end. Overall satisfaction with the ability of the product to reduce fatigue reached 85% at Day 90. Conclusion: Daily intake with G115® extract formulated with vitamins and minerals suggests an improvement of self-perception of fatigue and energy in a fatigued adult population.

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Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice

Channels ◽

10.4161/chan.4.1.10281 ◽

2010 ◽

Vol 4 (1) ◽

pp. 51-54 ◽

Cited By ~ 55

Author(s):

Brid Callaghan ◽

David J. Adams

Keyword(s):

Calcium Channels ◽

Sensory Neurons ◽

Knockout Mice ◽

Nicotinic Receptor

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Role of the GTP-Binding Protein Go in the Suppressant Effect of Ethanol on Voltage-Activated Calcium Channels of Murine Sensory Neurons

Alcoholism Clinical and Experimental Research ◽

10.1111/j.1530-0277.1994.tb00918.x ◽

1994 ◽

Vol 18 (3) ◽

pp. 608-615 ◽

Cited By ~ 10

Author(s):

Guo-Jie Huang ◽

Joseph J. McArdle

Keyword(s):

Calcium Channels ◽

Sensory Neurons ◽

Binding Protein ◽

Gtp Binding Protein ◽

Gtp Binding ◽

Suppressant Effect

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Biogenic silver and gold nanoparticles synthesized using red ginseng root extract, and their applications

Artificial Cells Nanomedicine and Biotechnology ◽

10.3109/21691401.2015.1008514 ◽

2015 ◽

pp. 1-6 ◽

Cited By ~ 21

Author(s):

Priyanka Singh ◽

Yeon Ju Kim ◽

Chao Wang ◽

Ramya Mathiyalagan ◽

Mohamed El-Agamy Farh ◽

...

Keyword(s):

Gold Nanoparticles ◽

Ginseng Root ◽

Root Extract ◽

Red Ginseng ◽

Silver And Gold Nanoparticles

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ANTIOXIDANT ACTIVITY AND TOTAL PHENOL AND FLAVONOIDS ANALYSIS OF SIBERIAN GINSENG ROOT

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2020v12i1.36830 ◽

2020 ◽

pp. 38-40

Author(s):

NAGENDAR SHETTY ◽

V. HARIKA ◽

SUMITRA LOKRAS

Keyword(s):

Antioxidant Activity ◽

Radical Scavenging ◽

Reducing Power ◽

Total Phenol ◽

Ginseng Root ◽

Root Extract ◽

Frap Assay ◽

Vitro Assay ◽

Siberian Ginseng

Objective: This study was examined to in vitro antioxidant activity and Total Phenol and Flavonoids content analysis of methanolic root extract of Eleutherococcus senticosus (Siberian ginseng). Methods: 1,1-dephenyl-2-picryl-hydrazyl free radical scavenging and FRAP assay propose that antioxidant activity of methanol root extract because of reducing capacity of the antioxidant against oxidative effects of reactive oxygen species. Results: Scavenging activity of Siberian ginseng root RC50 value was shown 713.42±11.55 µg/ml and reducing power 0.13±0.01 mmol/g was investigated. In addition, total phenol 12.6±1.13 mg GAE/g DW and total flavonoids 9.8±0.20 mg QE/g DW were recorded. Conclusion: Although all tests were performed in vitro assay, these results recommend that Siberian ginseng root may be a good source of antioxidant ingrediant.

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