An Open-Label, Pilot Trial of HRG80™ Red Ginseng in Chronic Fatigue Syndrome, Fibromyalgia, and Post-Viral Fatigue

Chronic fatigue syndrome and fibromyalgia (CFS/FMS) affect 2.1% of the world’s population and ~10–25% of people who have had COVID-19. Previous clinical data suggested that a unique Panax ginseng (C.A. Meyer, family Araliaceae) root extract (HRG80™ Red Ginseng) often resulted in marked improvement. We aimed to study this hydroponic form of red ginseng root, containing high levels of rare ginsenosides, for improving energy, cognition, and stamina. This open-label prospective study included participants with severe CFS/FMS who took a daily supplement of HRG80 capsules (200–400 mg) or tablets (100–200 mg) for one month. A total of 188 subject patients completed the one-month treatment trial. Of these, 60.1% rated themselves as improved, with 13.3% rating themselves as being much better. In this group, the mean composite score improved from 11.9 to 18.8 (p < 0.001), with a 67% average increase in energy, 44% average increase in overall well-being, 48% average improvement in mental clarity, 58% average composite improvement in the previous three measurements (primary outcome measure), 46% average improvement in sleep, 33% average decrease in pain, and 72% average increase in stamina. Our study showed that HRG80 red ginseng root powder resulted in a marked improvement in people with CFS and fibromyalgia. This included the subgroup with post-viral CFS/FMS.

Addition of Ginseng (Withania Somnifera) To the Diet and Its Effect on Productive Performance for Broilers Raised with Two Different Densities: إضافة الجينسنغ (Withania somnifera) إلى العليقة وتأثيره في الأداء الإنتاجي لفروج اللحم المربى بكثافتين مختلفتين

The study was conducted to find out the effect of adding ginseng root powder (Withania somnifera) at (0, 1.5 and 3.0) g/kg under two densities of breeding (12 and 17) birds/m2 on performance, economic indicators. Chicks were raised from the age 1 day-42 and distributed to the treatments at the second week in T1:12 bird\m2 +0%, T2:12 bird\m2 +1.5%,T3:12 bird\m2 +0.3%,T4:17bird\m2+0%,T5:17bird\m2+ 1.5%,T6:17 bird \m2 +0.3%.The statistical analysis showed that there was no significant difference in density in body weight, weight gain, relative growth, feed conversion factor, production index, production coefficient,while the density was 12 birds/ m2 superior in consumption The feed density of 17 birds/m2 gave a higher productivity in kg/m2 compared to 12 birds/m2. The addition of ginseng did not affect the weight gain, relative growth, conversion factor, index, production coefficient, productivity yield in kg/m2, while there was a superiority of adding (1.5 and 3.0) g of ginseng compared with no addition in live body weight and in Feed consumption and production factor and in the effect of the interaction there were no significant differences in the weight gain, growth, feed consumption, evidence and production factor, while we note that the interaction(12 birds/ m2+1.5 gm ginseng) gave the highest body weight and a significant improvement in the feed conversion factor for the addition of (1.5 and 3.0) gm under the influence of breeding density 17 birds/m2 and the productivity yield exceeded kg/m2.

A Systematic Study to Assess Displacement Performance of a Naturally-Derived Surfactant in Flow Porous Systems

For the first time, the present work assesses the feasibility of using Korean red ginseng root extract, a non-ionic surfactant, for the purposes of enhanced oil recovery (EOR). The surfactant is characterized by Fourier-transform infrared spectroscopy (FT-IR) analysis. Pendant drop and sessile drop techniques are employed to study the oil–water interfacial tension (IFT) and wettability nature of the sandstone rock, respectively. In addition, oil recovery enhancement is investigated using micromodel and core floods. In the salt-free system, IFT measurements indicate that the surfactant carries a critical micelle concentration of 5 g/L. In a saline medium (up to 50 g/L), the addition of a surfactant with different concentrations leads to an IFT reduction of 47.28–84.21%. In a constant surfactant concentration, a contact angle reduction is observed in the range of 5.61–9.30°, depending on salinity rate, revealing a wettability alteration toward more water-wet. Surfactant flooding in the glass micromodel provides a more uniform sweeping, which leads to an oil recovery enhancement of 3.02–11.19%, depending on the extent of salinity. An optimal salt concentration equal to 30 g/L can be recognized according to the results of previous tests. Surfactant flooding (10 g/L) in optimal salt concentration achieves an additional oil recovery of 7.52% after conventional water flooding.

Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics

Panax ginseng C.A.Mey. is an adaptogenic plant traditionally used to enhance mental and physical capacities in cases of weakness, exhaustion, tiredness, or loss of concentration, and during recovery. According to ancient records, red ginseng root preparations enhance longevity with long-term intake. Recent pharmacokinetic studies of ginsenosides in humans and our in vitro study in neuronal cells suggest that ginsenosides are effective when their levels in blood is low—at concentrations from 10−6 to 10−18 M. In the present study, we compared the effects of red ginseng root preparation HRG80TM(HRG) at concentrations from 0.01 to 10,000 ng/mL with effects of white ginseng (WG) and purified ginsenosides Rb1, Rg3, Rg5 and Rk1 on gene expression in isolated hippocampal neurons. The aim of this study was to predict the effects of differently expressed genes on cellular and physiological functions in organismal disorders and diseases. Gene expression profiling was performed by transcriptome-wide mRNA microarray analyses in murine HT22 cells after treatment with ginseng preparations. Ingenuity pathway downstream/upstream analysis (IPA) was performed with datasets of significantly up- or downregulated genes, and expected effects on cellular function and disease were identified by IPA software. Ginsenosides Rb1, Rg3, Rg5, and Rk1 have substantially varied effects on gene expression profiles (signatures) and are different from signatures of HRG and WG. Furthermore, the signature of HRG is changed significantly with dilution from 10,000 to 0.01 ng/mL. Network pharmacological analyses of gene expression profiles showed that HRG exhibits predictable positive effects in neuroinflammation, senescence, apoptosis, and immune response, suggesting beneficial soft-acting effects in cancer, gastrointestinal, and endocrine systems diseases and disorders in a wide range of low concentrations in blood.

Network Pharmacology of Ginseng (Part II): The Differential Effects of Red Ginseng and Ginsenoside Rg5 in Cancer and Heart Diseases as Determined by Transcriptomics

Panax ginseng C.A.Mey. is an adaptogenic plant traditionally used to enhance mental and physical capacities in cases of weakness, exhaustion, tiredness, loss of concentration, and during recovery. According to ancient records, Red Ginseng root preparations enhance longevity with long-term intake. Recent pharmacokinetic studies of ginsenosides in humans and our in vitro study in neuronal cells suggest that ginsenosides are effective when their level in blood is shallow - at concentrations from 10-6 to 10-18 M. In the present study, we compared the effects of Red Ginseng root preparation HRG80TM(HRG) at concentrations from 0.01 to 10,000 ng/ml with effects of White Ginseng (WG) and purified ginsenosides Rb1, Rg3, Rg5 and Rk1 on gene expression of isolated hippocampal neurons. The aim of this study was to predict the effects of differently expressed genes on cellular and physiological functions in organismal disorders and diseases. Gene expression profiling was performed by transcriptome-wide mRNA microarray analyses in murine HT22 cells after treatment with ginseng preparations. Ingenuity pathway downstream/upstream analysis (IPA) was performed with datasets of significantly up-or downregulated genes, and expected effects on cellular function and disease were identified by IPA software. Ginsenosides Rb1, Rg3, Rg5, and Rk1 have substantially various effects on gene expression profiles (signatures) and are different from signatures of HRG and WG. Furthermore, the signature of HRG is changed significantly with dilution from 10000 to 0.01 ng/ml. Network pharmacological analyses of gene expression profiles showed that HRG exhibits predictable positive effects in neuroinflammation, senescence, apoptosis, and immune response, suggesting beneficial soft-acting effects in cancer, gastrointestinal, and endocrine systems diseases and disorders in a wide range of low concentrations in blood.