Properties of excitatory vestibular nucleus neurons concerned with vestibular reflexes in the posterior semicircular canal system

BMP signalling is known to have a conserved function in development of the semicircular canal system of the vertebrate inner ear, but its regulation, target genes and effects on cell behaviour during otic morphogenesis are not fully understood. We have characterised the effects of mutations in the zebrafish gene bmper, which codes for a regulator of BMP signalling with both pro- and anti-BMP roles in different developmental contexts. The inner ears of bmper mutant embryos develop with truncations of the anterior and posterior semicircular canal ducts. To image the developing ear in live embryos, we have exploited a new transgenic line, Tg(smad6b:EGFP), which exhibits strong GFP expression in the otic epithelium. Morphometric analysis indicates defects in the bmper mutant ear from early stages of semicircular canal formation, correlating with a specific reduction in BMP signalling activity and specific loss of dlx5a expression in dorsal otic epithelium. Subsequent changes to cell shape occur at the truncation site and the dorsolateral septum. The bmper mutations that we describe are adult viable; truncation of the anterior and posterior semicircular canal ducts persists into adulthood. Our results argue against a major role for Bmper in specification of the pre-placodal region, induction of the otic placode, or development of the neural crest, processes in which Bmper function has previously been implicated. Instead, we conclude that a key requirement for Bmper function in the zebrafish is to promote BMP signalling during patterning and morphogenesis of the semicircular canal system.

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Resistant Posterior Semicircular Canal BPPV with Changing Oculomotor Pattern Solved with Mastoid Vibration Application

Otolaryngology Research and Reviews ◽

10.36959/926/541 ◽

2017 ◽

Vol 1 (1) ◽

Author(s):

Faralli Mario ◽

Lapenna Ruggero ◽

Gambacorta Valeria ◽

Ricci Giampietro ◽

D'Ascanio Luca

Keyword(s):

Semicircular Canal ◽

Posterior Semicircular Canal

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Correction: Epley manoeuvre for posterior semicircular canal benign paroxysmal positional vertigo in people with multiple sclerosis: protocol of a randomised controlled trial

BMJ Open ◽

10.1136/bmjopen-2020-046510corr1 ◽

2021 ◽

Vol 11 (4) ◽

pp. 1.3-1

Keyword(s):

Multiple Sclerosis ◽

Randomised Controlled Trial ◽

Semicircular Canal ◽

Benign Paroxysmal Positional Vertigo ◽

Controlled Trial ◽

Posterior Semicircular Canal ◽

Positional Vertigo ◽

Randomised Controlled ◽

Paroxysmal Positional Vertigo

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Current Therapies in Patients With Posterior Semicircular Canal BPPV, a Systematic Review and Network Meta-analysis

Otology & Neurotology ◽

10.1097/mao.0000000000003464 ◽

2022 ◽

Vol Publish Ahead of Print ◽

Author(s):

Daibo Li ◽

Danni Cheng ◽

Wenjie Yang ◽

Ting Chen ◽

Di Zhang ◽

...

Keyword(s):

Systematic Review ◽

Semicircular Canal ◽

Meta Analysis ◽

Posterior Semicircular Canal ◽

Current Therapies

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Behavior of the posterior semicircular canal after Dix-Hallpike maneuver

Audiology Research ◽

10.4081/audiores.2016.140 ◽

2016 ◽

Vol 6 (1) ◽

Author(s):

Francisco Carlos Zuma e Maia ◽

Pedro Luiz Mangabeira Albernaz ◽

Renato Valério Cal

Keyword(s):

Semicircular Canal ◽

Benign Paroxysmal Positional Vertigo ◽

Biomechanical Model ◽

Posterior Semicircular Canal ◽

Positional Vertigo ◽

Paroxysmal Positional Vertigo

The objective of the present study is to analyze the quantitative vestibulo-ocular responses in a group of patients with benign paroxysmal positional vertigo (BPPV) canalolithiasis and compare these data with the data of the tridimensional biomechanical model. This study was conducted on 70 patients that presented idiopathic posterior semicircular canal canalolithiasis. The diagnosis was obtained by Dix- Hallpike maneuvers recorded by videonystagmograph. The present study demonstrates that there is a significant correlation between the intensity of the nystagmus and its latency in cases of BPPV-idiopathic posterior semicircular canal canalolithiasis type. These findings are in agreement with those obtained in a tridimensional biomechanical model and are not related to the patients’ age.

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Semicircular canal system in early primates

Journal of Human Evolution ◽

10.1016/j.jhevol.2008.10.007 ◽

2009 ◽

Vol 56 (3) ◽

pp. 315-327 ◽

Cited By ~ 83

Author(s):

Mary T. Silcox ◽

Jonathan I. Bloch ◽

Doug M. Boyer ◽

Marc Godinot ◽

Timothy M. Ryan ◽

...

Keyword(s):

Semicircular Canal ◽

Canal System

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The efficacy of Epley and Semont maneuvers in posterior semicircular canal benign paroxysmal positional vertigo treatment: A short-term comparative study

Praxis of Otorhinolaryngology ◽

10.5606/kbbu.2021.73645 ◽

2021 ◽

Vol 9 (3) ◽

pp. 75-80

Author(s):

Mustafa Caner Kesimli

Keyword(s):

Comparative Study ◽

Semicircular Canal ◽

Benign Paroxysmal Positional Vertigo ◽

Posterior Semicircular Canal ◽

Short Term ◽

Positional Vertigo ◽

Epley Maneuver ◽

The One ◽

Paroxysmal Positional Vertigo

OBJECTIVE: This study aimed to compare the effectiveness of the Epley maneuver with the Semont maneuver in the treatment of posterior semicircular canal benign paroxysmal positional vertigo and observe differences in the resolution time of symptoms in the short-term follow-up. METHODS: Sixty patients with posterior semicircular canal benign paroxysmal positional vertigo (23 males, 37 females; median age: 44.9 years; range, 14 to 80 years) were included in the prospective randomized comparative study conducted in our clinic between April 2019 and October 2019. Diagnosis and treatment maneuvers were performed under videonystagmography examination. Participants were randomly selected after the diagnostic tests for the Epley maneuver and the Semont maneuver treatment groups. RESULTS: In the evaluation of vertigo with videonystagmography, 25 (83.3%) patients in the Epley maneuver group and 20 (66.6%) patients in the Semont maneuver group recovered in the one-week follow-up, and 28 (93.3%) patients in the Epley maneuver group and 24 (80%) patients in the Semont maneuver group recovered in the two-week follow-up. All patients in the Epley maneuver group recovered at the end of one month; four patients in the Semont maneuver group still had vertiginous symptoms (100% vs. 86.6%, p=0.04). There was a statistically significant difference between the Epley and Semont groups regarding visual analog scores at the one-week, two-week, and one-month follow-ups (p=0.002, p<0.001, p=0.001, respectively). CONCLUSION: The Epley maneuver was significantly more effective than the Semont maneuver in resolving vertigo in the short-term treatment of posterior semicircular canal benign paroxysmal positional vertigo.

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Design and Analysis of Posterior Semicircular Canal BPPV Diagnostic Test Based on Physical Simulation

10.21203/rs.3.rs-771908/v1 ◽

2021 ◽

Author(s):

Xiaokai Yang ◽

Qiancheng Yang ◽

Zhaobang Liu

Keyword(s):

Diagnostic Test ◽

Semicircular Canal ◽

Physical Simulation ◽

Normal Vector ◽

Forward Angle ◽

Unit Normal Vector ◽

Posterior Semicircular Canal ◽

Average Value ◽

Crista Ampullaris ◽

Unit Normal

Abstract To discusses and analyzes how to realize the design of posterior semicircular canal BPPV diagnostic maneuver. First, measure the spatial attitude of the human semicircular canal, establish a BPPV virtual simulation platform, then analyze the key positions of the maneuver, and finally design a new diagnostic maneuver according to the demand, and perform physical simulation verification. The average value of the unit normal vector of the right posterior semicircular plane is [ 0.660, 0.702, 0.266], after rotate -46.8 ° around Z axis and 15.4 ° around Y axis, it parallel to the X axis. After that, when the tilt back angle reaches 70 °, the free otoconia in the left utricle will fall into the common crus; when bend forward 53.3°, the unit normal vector of the crista ampullaris plane of the posterior semicircular canal to the XY plane; when bend forward angle reaches 30°, the otoconia slides to the opening of the ampulla; when bend forward angle reaches 70°, the otoconia slides to the bottom of the crista ampullaris. The shallow pitching Yang maneuver is designed as turn head 45° to the one side, bend forward 45°, tilt back 90°, and bend forward 90°. The deep pitching Yang maneuver is designed as bend forward 90°, turn head 45° to one side, tilt back 135°, and bend forward 90°. A new posterior semicircular BPPV diagnostic test is designed to make the induced nystagmus have the characteristics of long latency, reversal, and repeatability, will not cause the inhibitory stimulation of the contralateral superior semicircular canal, and has good operation fault tolerance, which is of great value for clinical and scientific research.

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