Ganglioside analysis of metastatic malignant melanoma with unknown primary lesion

1990 ◽  
Vol 1 (2) ◽  
pp. 116
Author(s):  
Junji Nakano ◽  
Takashi Imamura ◽  
Sumiko Hamanaka ◽  
Takahisa Ota ◽  
Chidori Asagami
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion: A Case Report

2017 ◽  
Vol 3 (2) ◽  
pp. 13
Author(s):  
Guddi Rani Singh ◽  
Jiut Ram Keshari ◽  
Bhim Ram ◽  
Vijayanand choudhary ◽  
Ravi Bhushan Raman
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Malignant Melanoma ◽  
Inguinal Lymph Node ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

scholarly journals Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Sherif Ali Eltawansy ◽  
Ryane Panasiti ◽  
Samaa Hasanien ◽  
Dennis Lourdusamy ◽  
David Sharon
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Spontaneous Regression ◽  
Inguinal Lymph Node ◽  
Cutaneous Lesion ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Primary Site ◽  
Unknown Primary ◽  
Cutaneous Lesions

Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spontaneous regression of the primary site could be an explanation.Case Report. We report a 58-year-old Caucasian male who presented with a right sided swelling in the inguinal region. Surgery was performed and biopsy showed metastatic malignant melanoma. No cutaneous lesions were identified by history or physical examination. Work up could not detect the primary lesion and patient was started on radiotherapy and immunotherapy.Conclusion. We present a case of malignant melanoma of unknown primary presenting in an unusual place which is the inguinal lymph node. Theories try to explain the pathway of development of such tumors and one of the theories mentions that it could be a spontaneous regression of the primary cutaneous lesion. Another theory is that it could be from transformation of aberrant melanocyte within the lymph node. Prognosis is postulated to be better in this case than in melanoma with a known primary.

Isolated Metastatic Malignant Melanoma of the Right Inguinal Lymph Node with Unknown Primary Lesion

2018 ◽  
Vol 8 (3) ◽  
pp. 174-176
Author(s):  
Debasish Das ◽  
Deb Prosad Paul ◽  
Kazi Sohel Iqbal
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Inguinal Lymph Node ◽  
Uv Light ◽  
Light Exposure ◽  
Metastatic Malignant Melanoma ◽  
Lymph Node Biopsy ◽  
Primary Lesion ◽  
Unknown Primary ◽  
Complete Excision

Malignant melanoma develops from the pigment containing cells known as melanocytes. Melanoma is more common in men than in women. It is found typically in the skin. It is also found in the mouth, intestine, eye and other sites. Melanoma may develop from a mole with changes including an increasing in size, irregular edges, changes in color, itchiness or skin breakdown. Prognosis is poor if it is not treated early. The primary cause of melanoma is UV light exposure. Patients with history of affected family members and poor immune function are at greater risk. Diagnosis is by biopsy from any affected skin lesion. Recurrence is common even many years after the initial diagnosis. Here we present a case of malignant melanoma of the inguinal lymph node with unknown primary lesion. Surgery was done with complete excision of inguinal lymph node. Biopsy report showed metastatic malignant melanoma.J Enam Med Col 2018; 8(3): 174-176

scholarly journals Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
George Tsaknis ◽  
Muhammad Naeem ◽  
Advitya Singh ◽  
Siddharth Vijayakumar
Keyword(s):  
Lung Cancer ◽  
Malignant Melanoma ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Past History ◽  
White Male ◽  
Pulmonary Nodules ◽  
Metastatic Malignant Melanoma ◽  
Unknown Primary ◽  
Solitary Pulmonary Nodules

Abstract Background Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Case presentation A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later. Conclusions Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.

Malignant melanoma of the chest wall with an unknown primary lesion

1998 ◽  
Vol 46 (5) ◽  
pp. 399-401 ◽  
Author(s):  
Goichi Yotsumoto ◽  
Shinji Shimokawa ◽  
Akihiro Yamaoka ◽  
Shun-ichi Watanabe ◽  
Yoshifumi Matsushita ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Chest Wall ◽  
Primary Lesion ◽  
Unknown Primary

scholarly journals Liver Metastases of Unknown Primary: Malignant Melanoma

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Ozgur Bostanci ◽  
Kinyas Kartal ◽  
Muharrem Battal
Keyword(s):  
Malignant Melanoma ◽  
Liver Metastases ◽  
Disease Free Survival ◽  
Metastatic Malignant Melanoma ◽  
Unknown Primary ◽  
Current Increase ◽  
Free Survival ◽  
Number Of Patients ◽  
Melanoma Prognosis ◽  
Disease Free Survival Rate

According to the National Cancer Institute’s (NCI) data, the increase in the number of patients diagnosed with malignant melanoma was found to be at a higher rate than the current increase in all other types of cancer (Jemal et al., 2008). Early diagnosis, appropriate surgical treatment, and chemotherapy have positive impacts on the course of the disease but despite these developments on the treatment, current prognosis of metastatic malignant melanoma prognosis is still extremely poor. Life expectancy in patients with metastatic disease is between 2 and 8 months. The 5-year disease-free survival rate is identified in only 5% of the patients (Leong, 2003) (Kirkwood et al., 1996). In this study, we try to report a patient with metastatic malignant melanoma and give recent informations about the liver metastases of malignant melanoma.

Giant Metastatic Malignant Melanoma with an Unknown Primary Site

1994 ◽  
Vol 21 (6) ◽  
pp. 442-446 ◽  
Author(s):  
Kazumasa Morita ◽  
Hitoshi Kudo ◽  
Kimio Fujii ◽  
Hiroyuki Okamoto ◽  
Kunio Matsubara ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site

scholarly journals Dural-Based Metastatic Malignant Melanoma Masquerading as Meningiomata: A Diagnostic Challenge

2020 ◽  
Vol 4 (1) ◽  
pp. 82-84
Author(s):  
Mina Zarei ◽  
MAHTAB Forouzandeh ◽  
Jennifer Ledon ◽  
George W Elgart ◽  
Jeong Hee Cho-Vega
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Radiographic Examination ◽  
Unknown Primary ◽  
Diagnostic Challenge ◽  
Immunohistochemistry Staining ◽  
Incorrect Diagnosis ◽  
Histopathologic Evaluation ◽  
Work Up ◽  
Rare Diagnosis

Despite both clinical and radiographic examination, metastases from malignant melanomas can be susceptible to misdiagnoses, particularly when they are found in uncommon locations. We report on an unsettling case of a 38-year-old woman who presented to neurosurgery with worsening neurological symptoms. Upon magnetic resonance imaging, the patient was found to have two sizeable dural-based lesions and underwent subsequent resection of the larger mass. Although the results of the pathohistological examination and immunohistochemistry staining were suspicious for metastatic malignant melanoma, an incorrect diagnosis of atypical meningioma was rendered due to the patient’s age and lack of melanoma history. After the patient’s condition continued to clinically deteriorate, dermatology was ultimately consulted and a more comprehensive work-up was carried out, revealing the correct and exceedingly rare diagnosis of dural-based metastatic melanoma of unknown primary. This case underscores the importance of an interdisciplinary diagnostic approach; one which employs comprehensive histopathologic evaluation, judiciously selected immunohistochemical staining, and thorough physical examination.

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