Isolated Metastatic Malignant Melanoma of the Right Inguinal Lymph Node with Unknown Primary Lesion

2018 ◽  
Vol 8 (3) ◽  
pp. 174-176
Author(s):  
Debasish Das ◽  
Deb Prosad Paul ◽  
Kazi Sohel Iqbal
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Inguinal Lymph Node ◽  
Uv Light ◽  
Light Exposure ◽  
Metastatic Malignant Melanoma ◽  
Lymph Node Biopsy ◽  
Primary Lesion ◽  
Unknown Primary ◽  
Complete Excision

Malignant melanoma develops from the pigment containing cells known as melanocytes. Melanoma is more common in men than in women. It is found typically in the skin. It is also found in the mouth, intestine, eye and other sites. Melanoma may develop from a mole with changes including an increasing in size, irregular edges, changes in color, itchiness or skin breakdown. Prognosis is poor if it is not treated early. The primary cause of melanoma is UV light exposure. Patients with history of affected family members and poor immune function are at greater risk. Diagnosis is by biopsy from any affected skin lesion. Recurrence is common even many years after the initial diagnosis. Here we present a case of malignant melanoma of the inguinal lymph node with unknown primary lesion. Surgery was done with complete excision of inguinal lymph node. Biopsy report showed metastatic malignant melanoma.J Enam Med Col 2018; 8(3): 174-176

Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion: A Case Report

2017 ◽  
Vol 3 (2) ◽  
pp. 13
Author(s):  
Guddi Rani Singh ◽  
Jiut Ram Keshari ◽  
Bhim Ram ◽  
Vijayanand choudhary ◽  
Ravi Bhushan Raman
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Malignant Melanoma ◽  
Inguinal Lymph Node ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

scholarly journals Metastatic Malignant Melanoma of the Inguinal Lymph Node with Unknown Primary Lesion

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Sherif Ali Eltawansy ◽  
Ryane Panasiti ◽  
Samaa Hasanien ◽  
Dennis Lourdusamy ◽  
David Sharon
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Spontaneous Regression ◽  
Inguinal Lymph Node ◽  
Cutaneous Lesion ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Primary Site ◽  
Unknown Primary ◽  
Cutaneous Lesions

Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spontaneous regression of the primary site could be an explanation.Case Report. We report a 58-year-old Caucasian male who presented with a right sided swelling in the inguinal region. Surgery was performed and biopsy showed metastatic malignant melanoma. No cutaneous lesions were identified by history or physical examination. Work up could not detect the primary lesion and patient was started on radiotherapy and immunotherapy.Conclusion. We present a case of malignant melanoma of unknown primary presenting in an unusual place which is the inguinal lymph node. Theories try to explain the pathway of development of such tumors and one of the theories mentions that it could be a spontaneous regression of the primary cutaneous lesion. Another theory is that it could be from transformation of aberrant melanocyte within the lymph node. Prognosis is postulated to be better in this case than in melanoma with a known primary.

Ganglioside analysis of metastatic malignant melanoma with unknown primary lesion

1990 ◽  
Vol 1 (2) ◽  
pp. 116
Author(s):  
Junji Nakano ◽  
Takashi Imamura ◽  
Sumiko Hamanaka ◽  
Takahisa Ota ◽  
Chidori Asagami
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Primary Lesion ◽  
Unknown Primary

Curative Intent Surgery of Oral Malignant Melanoma and Regional Lymph Node Biopsy Assessment in 25 Dogs: 2006–2017

2022 ◽  
pp. 089875642110723
Author(s):  
Matthew L. Raleigh ◽  
Mark M. Smith ◽  
Kendall Taney
Keyword(s):  
Lymph Node ◽  
Malignant Melanoma ◽  
Survival Time ◽  
Regional Lymph Node ◽  
Lymph Node Biopsy ◽  
Curative Intent ◽  
Complete Excision ◽  
Node Biopsy ◽  
Oral Malignant Melanoma ◽  
Definitive Surgery

Medical records were searched for dogs that had received curative intent surgery for oral malignant melanoma and ipsilateral excisional regional lymph node biopsy. Twenty-seven dogs were operated on and 25 dogs of these dogs met the inclusion criteria of signalment, post-excision margin status, presence of metastasis for each biopsied lymphocentrum, survival time post-excision, presence of recurrence or metastasis at follow-up or at death/euthanasia, location of the primary tumor, and any postoperative adjuvant treatment. These 25 dogs had complete tumor excision with tumor-free margins and 19 (76%) had postoperative adjuvant therapy. Median survival time after excision for the dogs in this study was 335.5 days. Results of this study support previous work that documents prolonged survival time following complete excision of oral malignant melanoma with tumor-free surgical margins in dogs. Additionally, 4 dogs (16%) had histologically confirmed regional lymph node metastasis at the time of definitive surgery.

scholarly journals Successful Alectinib Treatment for Carcinoma of Unknown Primary with EML4-ALK Fusion Gene: A Case Report

2021 ◽  
Vol 28 (3) ◽  
pp. 1938-1945
Author(s):  
Keiji Sugiyama ◽  
Ai Izumika ◽  
Akari Iwakoshi ◽  
Riko Nishibori ◽  
Mariko Sato ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cervical Lymph Node ◽  
Kinase Inhibitors ◽  
Fusion Gene ◽  
Liver Lesion ◽  
Lymph Node Biopsy ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Anaplastic Lymphoma ◽  
Lymph Node Swelling

Gene alteration in anaplastic lymphoma kinase (ALK) is rare, and the efficacy of ALK inhibitors in the treatment of carcinoma of unknown primary (CUP) with ALK alteration remains unclear. The patient was a 56-year-old woman who presented with cervical lymph node swelling. Computed tomography revealed paraaortic, perigastric, and cervical lymph node swelling; ascites; a liver lesion; and a left adrenal mass. A cervical lymph node biopsy was performed, and pathological diagnosis of an undifferentiated malignant tumor was conducted. Finally, the patient was diagnosed with CUP and treated with chemotherapy. To evaluate actionable mutations, we performed a multigene analysis, using a next-generation sequencer (FoundationOne® CDx). It revealed that the tumor harbored an echinoderm microtubule-associated protein-like 4 (EML4) and ALK fusion gene. Additionally, immunohistochemistry confirmed ALK protein expression. Alectinib, a potent ALK inhibitor, was recommended for the patient at a molecular oncology conference at our institution. Accordingly, alectinib (600 mg/day) was administered, and the multiple lesions and symptoms rapidly diminished without apparent toxicity. The administration of alectinib continued for a period of 10 months without disease progression. Thus, ALK-tyrosine kinase inhibitors should be considered in patients with CUP harboring the EML4-ALK fusion gene.

scholarly journals Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
George Tsaknis ◽  
Muhammad Naeem ◽  
Advitya Singh ◽  
Siddharth Vijayakumar
Keyword(s):  
Lung Cancer ◽  
Malignant Melanoma ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Past History ◽  
White Male ◽  
Pulmonary Nodules ◽  
Metastatic Malignant Melanoma ◽  
Unknown Primary ◽  
Solitary Pulmonary Nodules

Abstract Background Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Case presentation A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later. Conclusions Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.

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